The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The impaired NK cell cytolytic function in viremic HIV‐1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44)
Abstract
Signals leading to NK cell triggering are primarily mediated by natural cytotoxicity receptors (NCR) upon binding to as‐yet‐undefined cell surface ligand(s) on normal hematopoietic cells, pathogen‐infected cells or tumor cells. In this study we tried to determine whether the decreased NK cell cytolytic function that is observed in HIV‐1‐infected patients may be related to a decreased expression of NCR. In HIV‐1‐infected patients, freshly drawn, purified NK cells expressed significantly decreased surface densities of NKp46 and NKp30 NCR. The low surface density of NKp46, NKp30 and NKp44 was also confirmed in in‐vitro‐activated NK cell populations and NK cell clones derived from HIV‐1 patients compared with uninfected donors. This defective NCR expression in HIV‐1 patients was associated with a parallel decrease of NCR‐mediated killing of different tumor target cells. Thus, the present study indicates that the defective expression of NCR represents at least one of the possible mechanisms leading to the impaired NK cell function in HIV‐1 infection and it can contribute to explain the relatively high frequency of opportunistic tumors reported in cohorts of untreated patients before the occurrence of profound immunosuppression (<200 CD4+ cells/mm 3).
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Citations
Cites
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
Ruggeri, L., Capanni, M., Urbani, E., Perruccio, K., Shlomchik, W. D., Tosti, A., Posati, S., Rogaia, D., Frassoni, F., Aversa, F., et al. (2002) · Science · doi:10.1126/science.1068440 · Cited by 3,380
NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines
Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P., & Salazar-Mather, T. P. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.189 · Cited by 2,113
Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis
Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M. C., Biassoni, R., & Moretta, L. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.197 · Cited by 1,778
Self-citationRECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS
Moretta, A., Bottino, C., Vitale, M., Pende, D., Biassoni, R., Mingari, M. C., & Moretta, L. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.619 · Cited by 875
Self-citationPende, D., Parolini, S., Pessino, A., Sivori, S., Augugliaro, R., Morelli, L., Marcenaro, E., Accame, L., Malaspina, A., Biassoni, R., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.10.1505 · Cited by 798
Self-citationCastriconi, R., Cantoni, C., Della Chiesa, M., Vitale, M., Marcenaro, E., Conte, R., Biassoni, R., Bottino, C., Moretta, L., & Moretta, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730640100 · Cited by 726
Self-citationCostello, R. T., Sivori, S., Marcenaro, E., Lafage-Pochitaloff, M., Mozziconacci, M.-J., Reviron, D., Gastaut, J.-A., Pende, D., Olive, D., & Moretta, A. (2002) · Blood · doi:10.1182/blood.v99.10.3661 · Cited by 500
Self-citationSivori, S., Pende, D., Bottino, C., Marcenaro, E., Pessino, A., Biassoni, R., Moretta, L., & Moretta, A. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199905)29:05<1656::aid-immu1656>3.0.co;2-1 · Cited by 422
Self-citationAsai, O., Longo, D. L., Tian, Z. G., Hornung, R. L., Taub, D. D., Ruscetti, F. W., & Murphy, W. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1268 · Cited by 301
Oliva, A., Kinter, A. L., Vaccarezza, M., Rubbert, A., Catanzaro, A., Moir, S., Monaco, J., Ehler, L., Mizell, S., Jackson, R., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2323 · Cited by 291
Cited by
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Sivori, S., Vacca, P., Del Zotto, G., Munari, E., Mingari, M. C., & Moretta, L. (2019) · Cellular & Molecular Immunology · doi:10.1038/s41423-019-0206-4 · Cited by 555
Self-citationLethal influenza infection in the absence of the natural killer cell receptor gene Ncr1
Gazit, R., Gruda, R., Elboim, M., Arnon, T. I., Katz, G., Achdout, H., Hanna, J., Qimron, U., Landau, G., Greenbaum, E., et al. (2006) · Nature Immunology · doi:10.1038/ni1322 · Cited by 549
Activating natural cytotoxicity receptors of natural killer cells in cancer and infection
Koch, J., Steinle, A., Watzl, C., & Mandelboim, O. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.01.003 · Cited by 317
NK cells in HIV infection: Paradigm for protection or targets for ambush
Fauci, A. S., Mavilio, D., & Kottilil, S. (2005) · Nature Reviews Immunology · doi:10.1038/nri1711 · Cited by 306
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Metadata
- Authors
- De Maria, A., Fogli, M., Costa, P., Murdaca, G., Puppo, F., Mavilio, D., Moretta, A., & Moretta, L.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2003-08-04
- Volume
- 33
- Issue
- 9
- Pages
- 2410-2418
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2136034795
- Cited by
- 299
- References
- 28
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- De Maria, A., Fogli, M., Costa, P., Murdaca, G., Puppo, F., Mavilio, D., Moretta, A., & Moretta, L. (2003). The impaired NK cell cytolytic function in viremic HIV‐1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44). European Journal of Immunology. https://doi.org/10.1002/eji.200324141
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