The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.
NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines
Abstract
▪ Abstract Natural killer (NK) cells are populations of lymphocytes that can be activated to mediate significant levels of cytotoxic activity and produce high levels of certain cytokines and chemokines. NK cells respond to and are important in defense against a number of different infectious agents. The first indications for this function came from the observations that virus-induced interferons α/β (IFN-α and -β) are potent inducers of NK cell-mediated cytotoxicity, and that NK cells are important contributors to innate defense against viral infections. In addition to IFN-α/β, a wide range of other innate cytokines can mediate biological functions regulating the NK cell responses of cytotoxicity, proliferation, and gamma interferon (IFN-γ) production. Certain, but not all, viral infections induce interleukin 12 (IL-12) to elicit NK cell IFN-γ production and antiviral mechanisms. However, high levels of IFN-α/β appear to be unique and/or uniquely dominant in the context of viral infections and act to regulate other innate responses, including induction of NK cell proliferation in vivo and overall negative regulation of IL-12 production. A detailed picture is developing of particular innate cytokines activating NK cell responses and their consorted effects in providing unique endogenous milieus promoting downstream adaptive responses, most beneficial in defense against viral infections.
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Cites
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Vivier, E., Tomasello, E., Baratin, M., Walzer, T., & Ugolini, S. (2008) · Nature Immunology · doi:10.1038/ni1582 · Cited by 3,943
The biology of human natural killer-cell subsets
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Antiviral Actions of Interferons
Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743
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Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596
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Metadata
- Authors
- Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P., & Salazar-Mather, T. P.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1999-04
- Volume
- 17
- Issue
- 1
- Pages
- 189-220
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2099019634
- Cited by
- 2,113
- References
- 221
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines. https://app.cochat.ai/papers/10.1146/annurev.immunol.17.1.189
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- Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P., & Salazar-Mather, T. P. (1999). NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.17.1.189
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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