The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Immunisation with BCG and recombinant MVA85A induces long‐lasting, polyfunctional Mycobacterium tuberculosis‐specific CD4+ memory T lymphocyte populations
Open accessAbstract
In the search for effective vaccines against intracellular pathogens such as HIV, tuberculosis and malaria, recombinant viral vectors are increasingly being used to boost previously primed T cell responses. Published data have shown prime‐boost vaccination with BCG‐MVA85A (modified vaccinia virus Ankara expressing antigen 85A) to be highly immunogenic in humans as measured by ex vivo IFN‐γ ELISPOT. Here, we used polychromatic flow cytometry to investigate the phenotypic and functional profile of these vaccine‐induced Mycobacterium tuberculosis (M.tb) antigen 85A‐specific responses in greater detail. Promisingly, antigen 85A‐specific CD4+ T cells were found to be highly polyfunctional, producing IFN‐γ, TNF‐α, IL‐2 and MIP‐1β. Surface staining showed the responding CD4+ T cells to be relatively immature (CD45RO+ CD27 int CD57–); this observation was supported by the robust proliferative responses observed following antigenic stimulation. Furthermore, these phenotypic and functional properties were independent of clonotypic composition and epitope specificity, which was maintained through the different phases of the vaccine‐induced immune response. Overall, these data strongly support the use of MVA85A in humans as a boosting agent to expand polyfunctional M.tb‐specific CD4+ T cells capable of significant secondary responses.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Self-citationSeventeen-colour flow cytometry: unravelling the immune system
Perfetto, S. P., Chattopadhyay, P. K., & Roederer, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1416 · Cited by 1,019
Self-citationQuantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry
Chattopadhyay, P. K., Price, D. A., Harper, T. F., Betts, M. R., Yu, J., Gostick, E., Perfetto, S. P., Goepfert, P., Koup, R. A., De Rosa, S. C., et al. (2006) · Nature Medicine · doi:10.1038/nm1371 · Cited by 372
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Cell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,162
A multistage tuberculosis vaccine that confers efficient protection before and after exposure
Aagaard, C., Hoang, T., Dietrich, J., Cardona, P.-J., Izzo, A., Dolganov, G., Schoolnik, G. K., Cassidy, J. P., Billeskov, R., & Andersen, P. (2011) · Nature Medicine · doi:10.1038/nm.2285 · Cited by 527
CD8+ T cell efficacy in vaccination and disease
Appay, V., Douek, D. C., & Price, D. A. (2008) · Nature Medicine · doi:10.1038/nm.f.1774 · Cited by 393
Self-citationPotent CD8+ T-Cell Immunogenicity in Humans of a Novel Heterosubtypic Influenza A Vaccine, MVA-NP+M1
Berthoud, T. K., Hamill, M., Lillie, P. J., Hwenda, L., Collins, K. A., Ewer, K. J., Milicic, A., Poyntz, H. C., Lambe, T., Fletcher, H. A., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq015 · Cited by 384
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Metadata
- Authors
- Beveridge, N. E. R., Price, D. A., Casazza, J. P., Pathan, A. A., Sander, C. R., Asher, T. E., Ambrozak, D. R., Precopio, M. L., Scheinberg, P., Alder, N. C., Roederer, M., Koup, R. A., Douek, D. C., Hill, A. V. S., & McShane, H.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2007-10-24
- Volume
- 37
- Issue
- 11
- Pages
- 3089-3100
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2004690260
- Cited by
- 224
- References
- 4
- FWCI
- 15.28
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Immunisation with BCG and recombinant MVA85A induces long‐lasting, polyfunctional Mycobacterium tuberculosis‐specific CD4+ memory T lymphocyte populations. https://app.cochat.ai/papers/10.1002/eji.200737504
- The paper
- Beveridge, N. E. R., Price, D. A., Casazza, J. P., Pathan, A. A., Sander, C. R., Asher, T. E., Ambrozak, D. R., Precopio, M. L., Scheinberg, P., Alder, N. C., Roederer, M., Koup, R. A., Douek, D. C., Hill, A. V. S., & McShane, H. (2007). Immunisation with BCG and recombinant MVA85A induces long‐lasting, polyfunctional Mycobacterium tuberculosis‐specific CD4+ memory T lymphocyte populations. European Journal of Immunology. https://doi.org/10.1002/eji.200737504
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