The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Syk kinase is required for collaborative cytokine production induced through Dectin‐1 and Toll‐like receptors
Open accessAbstract
Recognition of microbial components by germ‐line encoded pattern recognition receptors (PRR) initiates immune responses to infectious agents. We and others have proposed that pairs or sets of PRR mediate host immunity. One such pair comprises the fungal β‐glucan receptor, Dectin‐1, which collaborates through an undefined mechanism with Toll‐like receptor 2 (TLR2) to induce optimal cytokine responses in macrophages. We show here that Dectin‐1 signaling through the spleen tyrosine kinase (Syk) pathway is required for this collaboration, which can also occur with TLR4, 5, 7 and 9. Deficiency of either Syk or the TLR adaptor MyD88 abolished collaborative responses, which include TNF, MIP‐1α and MIP‐2 production, and which are comparable to the previously described synergy between TLR2 and TLR4. Collaboration of the Syk and TLR/MyD88 pathways results in sustained degradation of the inhibitor of k B (I k B), enhancing NF k B nuclear translocation. These findings establish the first example of Syk‐ and MyD88‐coupled PRR collaboration, further supporting the concept that paired receptors collaborate to control infectious agents.
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Cites
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S., & Underhill, D. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021787 · Cited by 1,643
Cooperation of Toll-like receptor signals in innate immune defence
Trinchieri, G., & Sher, A. (2007) · Nature Reviews Immunology · doi:10.1038/nri2038 · Cited by 1,364
Dectin-1 Mediates the Biological Effects of β-Glucans
Brown, G. D., Herre, J., Williams, D. L., Willment, J. A., Marshall, A. S. J., & Gordon, S. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021890 · Cited by 1,205
Self-citationLeibundGut-Landmann, S., Groß, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E., Tybulewicz, V., Brown, G. D., Ruland, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1460 · Cited by 1,191
Self-citationDectin-1 is required for β-glucan recognition and control of fungal infection
Taylor, P. R., Tsoni, S. V., Willment, J. A., Dennehy, K. M., Rosas, M., Findon, H., Haynes, K., Steele, C., Botto, M., Gordon, S., et al. (2007) · Nature Immunology · doi:10.1038/ni1408 · Cited by 1,161
Self-citationDectin-1: a signalling non-TLR pattern-recognition receptor
Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158
Self-citationNapolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F., & Lanzavecchia, A. (2005) · Nature Immunology · doi:10.1038/ni1223 · Cited by 1,157
Rogers, N. C., Slack, E. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, D. L., Gordon, S., Tybulewicz, V. L., Brown, G. D., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.03.004 · Cited by 895
Self-citationCD36 is a sensor of diacylglycerides
Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zähringer, U., et al. (2005) · Nature · doi:10.1038/nature03253 · Cited by 873
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
Gross, O., Gewies, A., Finger, K., Schäfer, M., Sparwasser, T., Peschel, C., Förster, I., & Ruland, J. (2006) · Nature · doi:10.1038/nature04926 · Cited by 853
Cited by
The Fungal Cell Wall: Structure, Biosynthesis, and Function
Gow, N. A. R., Latge, J.-P., & Munro, C. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0035-2016 · Cited by 1,423
Self-citationActivation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’
Goodridge, H. S., Reyes, C. N., Becker, C. A., Katsumoto, T. R., Ma, J., Wolf, A. J., Bose, N., Chan, A. S. H., Magee, A. S., Danielson, M. E., et al. (2011) · Nature · doi:10.1038/nature10071 · Cited by 867
Human dectin-1 deficiency and mucocutaneous fungal infections
Ferwerda, B., Ferwerda, G., Plantinga, T. S., Willment, J. A., van Spriel, A. B., Venselaar, H., Elbers, C. C., Johnson, M. D., Cambi, A., Huysamen, C., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901053 · Cited by 752
Self-citationβ‐glucan recognition by the innate immune system
Goodridge, H. S., Wolf, A. J., & Underhill, D. M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00793.x · Cited by 688
Interactions of fungal pathogens with phagocytes
Erwig, L. P., & Gow, N. A. R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.21 · Cited by 626
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Metadata
- Authors
- Dennehy, K. M., Ferwerda, G., Faro‐Trindade, I., Pyż, E., Willment, J. A., Taylor, P. R., Kerrigan, A., Tsoni, S. V., Gordon, S., Meyer‐Wentrup, F., Adema, G. J., Kullberg, B., Schweighoffer, E., Tybulewicz, V., Mora‐Montes, H. M., Gow, N. A. R., Williams, D. L., Netea, M. G., & Brown, G. D.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2008-01-28
- Volume
- 38
- Issue
- 2
- Pages
- 500-506
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2103322081
- Cited by
- 373
- References
- 31
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dennehy, K. M., Ferwerda, G., Faro‐Trindade, I., Pyż, E., Willment, J. A., Taylor, P. R., Kerrigan, A., Tsoni, S. V., Gordon, S., Meyer‐Wentrup, F., Adema, G. J., Kullberg, B., Schweighoffer, E., Tybulewicz, V., Mora‐Montes, H. M., Gow, N. A. R., Williams, D. L., Netea, M. G., & Brown, G. D. (2008). Syk kinase is required for collaborative cytokine production induced through Dectin‐1 and Toll‐like receptors. European Journal of Immunology. https://doi.org/10.1002/eji.200737741
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