The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
β‐glucan recognition by the innate immune system
Open accessAbstract
Summary: β‐glucans are recognized by the innate immune system. This recognition plays important roles in host defense and presents specific opportunities for clinical modulation of the host immune response. Neutrophils, macrophages, and dendritic cells among others express several receptors capable of recognizing β‐glucan in its various forms. This review explores what is currently known about β‐glucan recognition and how this recognition stimulates immune responses. Special emphasis is placed on Dectin‐1, as we know the most about how this key β‐glucan receptor translates recognition into intracellular signaling, stimulates cellular responses, and participates in orchestrating the adaptive immune response.
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Nonfilamentous C. albicans Mutants Are Avirulent
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Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
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Self-citationThe Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
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Self-citationVirulence factors of Candida albicans
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Dectin-1 Mediates the Biological Effects of β-Glucans
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Dectin-1 is required for β-glucan recognition and control of fungal infection
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“similarly observed that IL-17Rdeficient mice are highly susceptible to oropharyngeal Candida infection (91).”
BackgroundDectin-1 Is A Major β-Glucan Receptor On Macrophages
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Colonization by Pneumocystis jirovecii and Its Role in Disease
Morris, A., & Norris, K. A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00013-12 · Cited by 429
C-type lectin receptors in antifungal immunity
Willment, J. A., & Brown, G. D. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2007.10.012 · Cited by 269
Impact of aging on dendritic cell functions in humans
Agrawal, A., & Gupta, S. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.06.004 · Cited by 246
Ma, J., Becker, C., Lowell, C. A., & Underhill, D. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.382812 · Cited by 198
Self-citationLong-lived effects of administering β-glucans: Indications for trained immunity in fish
Petit, J., & Wiegertjes, G. F. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.03.003 · Cited by 196
Metadata
- Authors
- Goodridge, H. S., Wolf, A. J., & Underhill, D. M.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2009-06-29
- Volume
- 230
- Issue
- 1
- Pages
- 38-50
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2066222426
- Cited by
- 688
- References
- 99
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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