The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells
Open accessAbstract
IL‐17 and IL‐22 are typical cytokines produced by the Th17 T cell subset, but it is unclear if Th17 cytokines can be produced by other cell types. We demonstrate that IL‐10‐deficient and IL‐10R‐deficient macrophages stimulated with lipopolysaccharide produce high levels of IL‐17 and IL‐22. Addition of exogenous IL‐10 to IL‐10‐deficient macrophages abolished IL‐17 production. When IL‐10‐deficient and IL‐10R‐deficient splenocytes were cultured under Th17 polarizing conditions, the population of IL‐17‐producing cells was increased and the cultures produced significantly higher levels of IL‐17 and IL‐22. The addition of recombinant IL‐10 to IL‐10‐deficient splenocytes significantly decreased the percentage of IL‐17‐producing CD4+ T cells. Finally, the mRNA for the Th17 transcription factor retinoic acid‐related orphan receptor (ROR)γt was significantly elevated in IL‐10‐deficient spleen cells and macrophages. These data demonstrate that Th17 cytokines and RORγt are also expressed in macrophages and that IL‐10 negatively regulates the expression of Th17 cytokines and RORγt by both macrophages and T cells.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Transforming growth factor-β induces development of the TH17 lineage
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Cited by
Chaudhry, A., Samstein, R. M., Treuting, P., Liang, Y., Pils, M. C., Heinrich, J.-M., Jack, R. S., Wunderlich, F. T., Brüning, J. C., Müller, W., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.018 · Cited by 980
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
de la Cruz-López, K. G., Castro-Muñoz, L. J., Reyes-Hernández, D. O., García-Carrancá, A., & Manzo-Merino, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01143 · Cited by 940
“Also, IL-10 inhibits Th1 differentiation and production of IL-12 (153).”
BackgroundInfluentialJetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 673
Shouval, D. S., Biswas, A., Goettel, J. A., McCann, K., Conaway, E., Redhu, N. S., Mascanfroni, I. D., Al Adham, Z., Lavoie, S., Ibourk, M., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.011 · Cited by 584
The role of inflammation in the pathology of preeclampsia
Harmon, A. C., Cornelius, D. C., Amaral, L. M., Faulkner, J. L., Cunningham, M. W., Wallace, K., & LaMarca, B. (2016) · Clinical Science · doi:10.1042/cs20150702 · Cited by 565
Metadata
- Authors
- Gu, Y., Yang, J., Ouyang, X., Liu, W., Li, H., Yang, J., Bromberg, J., Chen, S., Mayer, L., Unkeless, J. C., & Xiong, H.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2008-06-25
- Volume
- 38
- Issue
- 7
- Pages
- 1807-1813
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2034016494
- Cited by
- 221
- References
- 9
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gu, Y., Yang, J., Ouyang, X., Liu, W., Li, H., Yang, J., Bromberg, J., Chen, S., Mayer, L., Unkeless, J. C., & Xiong, H. (2008). Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells. European Journal of Immunology. https://doi.org/10.1002/eji.200838331
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