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Cited by 584

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

Open access
Shouval, Dror S., Biswas, Amlan, Goettel, Jeremy A., McCann, Katelyn, Conaway, Evan, Redhu, Naresh S., Mascanfroni, Ivan D., Al Adham, Ziad, Lavoie, Sydney, Ibourk, Mouna, Nguyen, Deanna D., Samsom, Janneke N., Escher, Johanna C., Somech, Raz, Weiss, Batia, Beier, Rita, Conklin, Laurie S., Ebens, Christen L., Santos, Fernanda G.M.S., Ferreira, Alexandre R., Sherlock, Mary, Bhan, Atul K., Müller, Werner, Mora, J. Rodrigo, Quintana, Francisco J., Klein, Christoph, Muise, Aleixo M., Horwitz, Bruce H., Snapper, Scott B.·2014·Immunity
DOI 10.1016/j.immuni.2014.03.011
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Abstract

Summary Intact interkeulin-10 receptor (IL-10R) signaling on effector and regulatory T (Treg) cells are each independently required to maintain immune tolerance. Here we show that IL-10 sensing by innate immune cells, independent of its effects on T cells, was critical for regulating mucosal homeostasis. Following wild-type CD4+ T cell transfer, Rag2−/−Il10rb−/− mice developed severe colitis in association with profound defects in generation and function of Treg cells. Moreover, loss of IL-10R signaling impaired the generation and function of anti-inflammatory intestinal and bone marrow-derived macrophages, and their ability to secrete IL-10. Importantly, transfer of wild-type but not Il10rb−/− anti-inflammatory macrophages ameliorated colitis induction by wild-type CD4+ T cells in Rag2−/−Il10rb−/− mice. Similar alterations in the generation and function of anti-inflammatory macrophages were observed in IL-10R-deficient patients with very early-onset inflammatory bowel disease. Collectively, our studies define innate immune IL-10R signaling as a key factor regulating mucosal immune homeostasis in mice and humans.

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Metadata

Authors
Shouval, D. S., Biswas, A., Goettel, J. A., McCann, K., Conaway, E., Redhu, N. S., Mascanfroni, I. D., Al Adham, Z., Lavoie, S., Ibourk, M., Nguyen, D. D., Samsom, J. N., Escher, J. C., Somech, R., Weiss, B., Beier, R., Conklin, L. S., Ebens, C. L., Santos, F. G. M. S., Ferreira, A. R., Sherlock, M., Bhan, A. K., Müller, W., Mora, J. R., Quintana, F. J., Klein, C., Muise, A. M., Horwitz, B. H., & Snapper, S. B.
Venue
Immunity
Publisher
Elsevier BV
Published
2014-05
Volume
40
Issue
5
Pages
706-719
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2014.03.011
OpenAlex
W2043897018
Cited by
584
References
52
FWCI
19.06
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function. https://app.cochat.ai/papers/10.1016/j.immuni.2014.03.011
The paper
Shouval, D. S., Biswas, A., Goettel, J. A., McCann, K., Conaway, E., Redhu, N. S., Mascanfroni, I. D., Al Adham, Z., Lavoie, S., Ibourk, M., Nguyen, D. D., Samsom, J. N., Escher, J. C., Somech, R., Weiss, B., Beier, R., Conklin, L. S., Ebens, C. L., Santos, F. G. M. S., . . . Snapper, S. B. (2014). Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function. Immunity. https://doi.org/10.1016/j.immuni.2014.03.011

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.