Essential differences in ligand presentation and T cell epitope recognition among HLA molecules of the HLA‐B44 supertype

Hillen, Nina; Mester, Gabor; Lemmel, Claudia; Weinzierl, Andreas O.; Müller, Margret; Wernet, Dorothee; Hennenlotter, Jörg; Stenzl, Arnulf; Rammensee, Hans‐Georg; Stevanović, Stefan

doi:10.1002/eji.200838632

Essential differences in ligand presentation and T cell epitope recognition among HLA molecules of the HLA‐B44 supertype

Human leukocyte antigens (HLA) have long been grouped into supertypes to facilitate peptide‐based immunotherapy. Analysis of several hundreds of peptides presented by all nine antigens of the HLA‐B44 supertype (HLA‐B * 18, B * 37, B * 40, B * 41, B * 44, B * 45, B * 47, B * 49 and B * 50) reveale…