Peripheral and systemic antigens elicit an expandable pool of resident memory CD8 + T cells in the bone marrow

BM has been put forward as a major reservoir for memory CD8 + T cells. In order to fulfill that function, BM should “store” memory CD8 + T cells, which in biological terms would require these “stored” memory cells to be in disequilibrium with the circulatory pool. This issue is a matter of ongoin…