Tissue-resident memory T cells: local specialists in immune defence

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992 · see citing works

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · see citing works

Lineage relationship and protective immunity of memory CD8 T cell subsets

Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864 · see citing works

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861 · see citing works

Immunological memory and protective immunity: understanding their relation

Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775 · see citing works

Transcriptional control of effector and memory CD8+ T cell differentiation

Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628 · see citing works

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

Mackay, L. K., Rahimpour, A., Ma, J. Z., Collins, N., Stock, A. T., Hafon, M.-L., Vega-Ramos, J., Lauzurica, P., Mueller, S. N., Stefanovic, T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2744 · Cited by 1,331 · see citing works

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,257 · see citing works

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157 · see citing works

Tissue-Resident Memory T Cells

Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059 · see citing works

Visualizing the generation of memory CD4 T cells in the whole body

Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., & Jenkins, M. K. (2001) · Nature · doi:10.1038/35065111 · Cited by 1,026 · see citing works

Control of Effector CD8 ⁺ T Cell Function by the Transcription Factor <i>Eomesodermin</i>

Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., et al. (2003) · Science · doi:10.1126/science.1090148 · Cited by 1,014 · see citing works

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

Fuchs, A. G., Vermi, W., Lee, J. S., Lonardi, S., Gilfillan, S., Newberry, R. D., Cella, M., & Colonna, M. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.010 · Cited by 904 · see citing works

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

Jiang, X., Clark, R. A., Liu, L., Wagers, A. J., Fuhlbrigge, R. C., & Kupper, T. S. (2012) · Nature · doi:10.1038/nature10851 · Cited by 883 · see citing works

Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets

Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J. J. C., Bickham, K. L., Lerner, H., Goldstein, M., Sykes, M., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.09.020 · Cited by 848 · see citing works

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

Naik, S., Bouladoux, N., Linehan, J. L., Han, S.-J., Harrison, O. J., Wilhelm, C., Conlan, S., Himmelfarb, S., Byrd, A. L., Deming, C., et al. (2015) · Nature · doi:10.1038/nature14052 · Cited by 820 · see citing works

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

Skon, C. N., Lee, J.-Y., Anderson, K. G., Masopust, D., Hogquist, K. A., & Jameson, S. C. (2013) · Nature Immunology · doi:10.1038/ni.2745 · Cited by 817 · see citing works

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 816 · see citing works

Intravascular staining for discrimination of vascular and tissue leukocytes

Anderson, K. G., Mayer-Barber, K., Sung, H., Beura, L., James, B. R., Taylor, J. J., Qunaj, L., Griffith, T. S., Vezys, V., Barber, D. L., et al. (2014) · Nature Protocols · doi:10.1038/nprot.2014.005 · Cited by 812 · see citing works

The Vast Majority of CLA+ T Cells Are Resident in Normal Skin

Clark, R. A., Chong, B., Mirchandani, N., Brinster, N. K., Yamanaka, K.-I., Dowgiert, R. K., & Kupper, T. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4431 · Cited by 796 · see citing works

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

Mackay, C. R., Marston, W. L., & Dudler, L. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.3.801 · Cited by 791 · see citing works

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

Schenkel, J. M., Fraser, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. (2014) · Science · doi:10.1126/science.1254536 · Cited by 731 · see citing works

Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1

Zhou, X.-Y., Yu, S.-Y., Zhao, D.-M., Harty, J., Badovinac, V., & Xue, H.-H. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.002 · Cited by 689 · see citing works

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. (2015) · Cell · doi:10.1016/j.cell.2015.03.031 · Cited by 685 · see citing works

Intravascular Immune Surveillance by CXCR6+ NKT Cells Patrolling Liver Sinusoids

Geissmann, F., Cameron, T. O., Sidobre, S., Manlongat, N., Kronenberg, M., Briskin, M., Dustin, M. L., & Littman, D. R. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030113 · Cited by 681 · see citing works

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Jarvis, M. A., Oswald, K. A., Trubey, C. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1935 · Cited by 674 · see citing works

The multifaceted role of CD4+ T cells in CD8+ T cell memory

Laidlaw, B. J., Craft, J. E., & Kaech, S. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.10 · Cited by 657 · see citing works

Sensing and alarm function of resident memory CD8+ T cells

Schenkel, J., Fraser, K. A., Vezys, V., & Masopust, D. (2013) · Nature Immunology · doi:10.1038/ni.2568 · Cited by 648 · see citing works

A vaccine strategy that protects against genital herpes by establishing local memory T cells

Shin, H., & Iwasaki, A. (2012) · Nature · doi:10.1038/nature11522 · Cited by 646 · see citing works

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A. E., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K. A., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200402 · Cited by 642 · see citing works

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

Teijaro, J. R., Turner, D., Pham, Q., Wherry, E. J., Lefrançois, L., & Farber, D. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102243 · Cited by 641 · see citing works

Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

Mackay, L. K., Stock, A. T., Ma, J., Jones, C. M., Kent, S., Mueller, S. N., Heath, W., Carbone, F., & Gebhardt, T. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1202288109 · Cited by 638 · see citing works

The integration of T cell migration, differentiation and function

Masopust, D., & Schenkel, J. M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3442 · Cited by 629 · see citing works

Dynamic T cell migration program provides resident memory within intestinal epithelium

Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20090858 · Cited by 628 · see citing works

Spatial map of human T cell compartmentalization and maintenance over decades of life

Thome, J. J. C., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y., & Farber, D. L. (2014) · Cell · doi:10.1016/j.cell.2014.10.026 · Cited by 587 · see citing works

Molecular regulation of effector and memory T cell differentiation

Chang, J. T., Wherry, E. J., & Goldrath, A. W. (2014) · Nature Immunology · doi:10.1038/ni.3031 · Cited by 578 · see citing works

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

Wakim, L. M., Davis, A. S. W., & Bevan, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010201107 · Cited by 577 · see citing works

Liver-resident NK cells confer adaptive immunity in skin-contact inflammation

Peng, H. C., Jiang, X., Chen, Y., Sojka, D. K., Wei, H., Gao, X., Sun, R., Yokoyama, W. M., & Tian, Z. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66381 · Cited by 546 · see citing works

CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help

Nakanishi, Y., Lu, B., Gerard, C. J., & Iwasaki, A. (2009) · Nature · doi:10.1038/nature08511 · Cited by 545 · see citing works

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

Sojka, D. K., Plougastel-Douglas, B., Yang, L., Pak-Wittel, M. A., Artyomov, M. N., Ivanova, Y., Zhong, C., Chase, J. M., Rothman, P. B., Yu, J. L., et al. (2014) · eLife · doi:10.7554/elife.01659 · Cited by 545 · see citing works

Lung‐resident memory CD8 T cells (TRM) are indispensable for optimal cross‐protection against pulmonary virus infection

Wu, T., Hu, Y., Lee, Y.-T., Bouchard, K. R., Benechet, A. P., Khanna, K., & Cauley, L. S. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.0313180 · Cited by 537 · see citing works

Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert

Ariotti, S., Hogenbirk, M. A., Dijkgraaf, F. E., Visser, L. L., Hoekstra, M. E., Song, J., Jacobs, H., Haanen, J. B. A. G., & Schumacher, T. N. (2014) · Science · doi:10.1126/science.1254803 · Cited by 534 · see citing works

Different patterns of peripheral migration by memory CD4+ and CD8+ T cells

Gebhardt, T., Whitney, P. G., Zaid, A., Mackay, L. K., Brööks, A. G., Heath, W. R., Carbone, F. R., & Mueller, S. N. (2011) · Nature · doi:10.1038/nature10339 · Cited by 529 · see citing works

Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics

Bromley, S. K., Thomas, S. Y., & Luster, A. D. (2005) · Nature Immunology · doi:10.1038/ni1240 · Cited by 509 · see citing works

Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

Mackay, L. K., Braun, A., Macleod, B. L., Collins, N., Tebartz, C., Bedoui, S., Carbone, F. R., & Gebhardt, T. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402256 · Cited by 503 · see citing works

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues

Debes, G. F., Arnold, C. N., Young, A. J., Krautwald, S., Lipp, M., Hay, J. B., & Butcher, E. C. (2005) · Nature Immunology · doi:10.1038/ni1238 · Cited by 478 · see citing works

Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues

Wakim, L., Waithman, J., van Rooijen, N., Heath, W., & Carbone, F. (2008) · Science · doi:10.1126/science.1151869 · Cited by 473 · see citing works

Migration, maintenance and recall of memory T cells in peripheral tissues

Woodland, D. L., & Kohlmeier, J. E. (2009) · Nature reviews. Immunology · doi:10.1038/nri2496 · Cited by 433 · see citing works

Epidermal Th22 and Tc17 Cells Form a Localized Disease Memory in Clinically Healed Psoriasis

Cheuk, S., Wikén, M., Blomqvist, L., Nylén, S., Talme, T., Ståhle, M., & Eidsmo, L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302313 · Cited by 421 · see citing works

A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells

Iijima, N., & Iwasaki, A. (2014) · Science · doi:10.1126/science.1257530 · Cited by 420 · see citing works

The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets

Yang, C. Y., Best, J. A., Knell, J., Yang, E., Sheridan, A. D., Jesionek, A. K., Li, H. S., Rivera, R. R., Lind, K. C., D’Cruz, L. M., et al. (2011) · Nature Immunology · doi:10.1038/ni.2158 · Cited by 411 · see citing works

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection

Badovinac, V. P., Haring, J. S., & Harty, J. T. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.013 · Cited by 406 · see citing works

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

Smigiel, K. S., Richards, E. A., Srivastava, S., Thomas, K. R., Dudda, J. C., Klonowski, K. D., & Campbell, D. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131142 · Cited by 406 · see citing works

Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention

Zhang, N., & Bevan, M. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.019 · Cited by 403 · see citing works

Lung niches for the generation and maintenance of tissue-resident memory T cells

Turner, D., Bickham, K. L., Thome, J. J. C., Kim, C. Y., D’Ovidio, F., Wherry, E. J., & Färber, D. L. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.67 · Cited by 399 · see citing works

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

Lynch, L., Michelet, X., Zhang, S., Brennan, P. J., Moseman, E. A., Lester, C., Besra, G. S., Vomhof‐DeKrey, E. E., Tighe, M., Koay, H., et al. (2014) · Nature Immunology · doi:10.1038/ni.3047 · Cited by 387 · see citing works

Dynamics of Blood-Borne CD8 Memory T Cell Migration In Vivo

Klonowski, K. D., Williams, K., Marzo, A. L., Blair, D. A., Lingenheld, E. G., & Lefrançois, L. (2004) · Immunity · doi:10.1016/s1074-7613(04)00103-7 · Cited by 383 · see citing works

A mucosal vaccine against <i>Chlamydia trachomatis</i> generates two waves of protective memory T cells

Stary, G., Olive, A., Radovic-Moreno, A. F., Gondek, D., Alvarez, D., Basto, P. A., Perro, M., Vrbanac, V. D., Tager, A. M., Shi, J., et al. (2015) · Science · doi:10.1126/science.aaa8205 · Cited by 379 · see citing works

Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients

Clark, R. A., Watanabe, R., Teague, J. E., Schlapbach, C., Tawa, M. C., Adams, N., Dorosario, A. A., Chaney, K. S., Cutler, C. S., LeBoeuf, N. R., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003008 · Cited by 367 · see citing works

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

Laidlaw, B. J., Zhang, N., Marshall, H. D., Staron, M. M., Guan, T., Hu, Y., Cauley, L. S., Craft, J. E., & Kaech, S. M. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.007 · Cited by 366 · see citing works

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

Wakim, L. M., Davis, A. S. W., Liu, R., Hu, Y., Villadangos, J. A., Smyth, G. K., & Bevan, M. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201305 · Cited by 365 · see citing works

Persistence of HIV-1 receptor–positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition

Zhu, J., Hladik, F., Davis, A. S. W., Klock, A. M., Peng, T., Johnston, C., Remington, M. L., Magaret, A., Koelle, D. M., Wald, A., et al. (2009) · Nature Medicine · doi:10.1038/nm.2006 · Cited by 357 · see citing works

Cutting Edge: Gut Microenvironment Promotes Differentiation of a Unique Memory CD8 T Cell Population

Masopust, D., Vezys, V., Wherry, E. J., Barber, D. L., & Ahmed, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2079 · Cited by 357 · see citing works

Regulatory T cells in nonlymphoid tissues

Burzyn, D., Benoist, C. O., & Mathis, D. J. (2013) · Nature Immunology · doi:10.1038/ni.2683 · Cited by 342 · see citing works

Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation

Zhu, J., Koelle, D. M., Cao, J., Vazquez, J., Huang, M. L., Hladik, F., Wald, A., & Corey, L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061792 · Cited by 340 · see citing works

Oral infection drives a distinct population of intestinal resident memory CD8+ T cells with enhanced protective function

Sheridan, B., Pham, Q.-M., Lee, Y.-T., Cauley, L., Puddington, L., & Lefrançois, L. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.007 · Cited by 332 · see citing works

Intravascular staining redefines lung CD8 T cell responses

Anderson, K., Sung, H., Skon, C. N., Lefrançois, L., Deisinger, A., Vezys, V., & Masopust, D. (2012) · Journal of Immunology · doi:10.4049/jimmunol.1201682 · Cited by 309 · see citing works

Persistence of skin-resident memory T cells within an epidermal niche

Zaid, A., Mackay, L. K., Rahimpour, A., Braun, A., Veldhoen, M., Carbone, F. R., Manton, J. H., Heath, W. R., & Mueller, S. N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322292111 · Cited by 306 · see citing works

Common clonal origin of central and resident memory T cells following skin immunization

Gaide, O., Emerson, R., Jiang, X., Gulati, N., Nizza, S. T., Desmarais, C., Robins, H. S., Krueger, J. G., Clark, R. A., & Kupper, T. S. (2015) · Nature Medicine · doi:10.1038/nm.3860 · Cited by 290 · see citing works

Resident Memory T Cells (TRM) Are Abundant in Human Lung: Diversity, Function, and Antigen Specificity

Purwar, R., Campbell, J. J., Murphy, G. F., Richards, W. G., Clark, R. A., & Kupper, T. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016245 · Cited by 286 · see citing works

Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection

Zhu, J., Peng, T., Johnston, C., Phasouk, K., Kask, A. S., Klock, A. M., Jin, L., Diem, K., Koelle, D. M., Wald, A., et al. (2013) · Nature · doi:10.1038/nature12110 · Cited by 280 · see citing works

Tissue-resident memory CD8 + T cells continuously patrol skin epithelia to quickly recognize local antigen

Ariotti, S., Beltman, J. B., Chodaczek, G., Hoekstra, M. E., van Beek, A. E., Gomez, R., Ritsma, L., van Rheenen, J., Marée, A. F. M., Żal, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208927109 · Cited by 274 · see citing works

Proinflammatory microenvironments within the intestine regulate differentiation of tissue-resident CD8 T cells responding to infection

Bergsbaken, T., & Bevan, M. (2015) · Nature Immunology · doi:10.1038/ni.3108 · Cited by 269 · see citing works

Residual Antigen Presentation after Influenza Virus Infection Affects CD8 T Cell Activation and Migration

Zammit, D. J., Turner, D., Klonowski, K. D., Lefrançois, L., & Cauley, L. S. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.015 · Cited by 262 · see citing works

Tissue‐specific migration pathways by phenotypically distinct subpopulations of memory T cells

Mackay, C. R., Marston, W. L., Dudler, L., Spertini, O., Tedder, T. F., & Hein, W. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220402 · Cited by 245 · see citing works

Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria

Schmidt, N. W., Podyminogin, R. L., Butler, N. S., Badovinac, V. P., Tucker, B. J., Bahjat, K. S., Lauer, P., Reyes‐Sandoval, A., Hutchings, C. L., Moore, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805452105 · Cited by 238 · see citing works

Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

Natsuaki, Y., Egawa, G., Nakamizo, S., Ono, S., Hanakawa, S., Okada, T., Kusuba, N., Otsuka, A., Kitoh, A., Honda, T., et al. (2014) · Nature Immunology · doi:10.1038/ni.2992 · Cited by 232 · see citing works

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus

Slütter, B., Pewe, L. L., Kaech, S. M., & Harty, J. T. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.013 · Cited by 228 · see citing works

Memory CD8 T-cell compartment grows in size with immunological experience

Vezys, V., Yates, A. J., Casey, K. A., Lanier, G., Ahmed, R., Antia, R., & Masopust, D. (2008) · Nature · doi:10.1038/nature07486 · Cited by 218 · see citing works

Cutting Edge: Resident Memory CD8 T Cells Occupy Frontline Niches in Secondary Lymphoid Organs

Schenkel, J. M., Fraser, K. A., & Masopust, D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400003 · Cited by 216 · see citing works

Enhanced survival of lung tissue-resident memory CD8+ T cells during infection with influenza virus due to selective expression of IFITM3

Wakim, L. M., Gupta, N., Mintern, J. D., & Villadangos, J. A. (2013) · Nature Immunology · doi:10.1038/ni.2525 · Cited by 214 · see citing works

Skin-resident memory CD4+ T cells enhance protection against <i>Leishmania major</i> infection

Glennie, N. D., Yeramilli, V. A., Beiting, D. P., Volk, S. W., Weaver, C. T., & Scott, P. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142101 · Cited by 204 · see citing works

PLZF induces an intravascular surveillance program mediated by long-lived LFA-1–ICAM-1 interactions

Thomas, S. Y., Scanlon, S. T., Griewank, K., Constantinides, M. G., Savage, A. K., Barr, K., Meng, F., Luster, A. D., & Bendelac, A. S. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102630 · Cited by 202 · see citing works

Mucosal Resident Memory CD4 T Cells in Protection and Immunopathology

Turner, D., & Färber, D. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00331 · Cited by 198 · see citing works

Memory T Cell Populations in the Lung Airways Are Maintained by Continual Recruitment

Ely, K. H., Cookenham, T. S., Roberts, A. D., & Woodland, D. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.1.537 · Cited by 187 · see citing works

Environmental and Antigen Receptor-Derived Signals Support Sustained Surveillance of the Lungs by Pathogen-Specific Cytotoxic T Lymphocytes

Lee, Y., Suarez-Ramirez, J. E., Wu, T., Redman, J. M., Bouchard, K. R., Hadley, G. A., & Cauley, L. S. (2011) · Journal of Virology · doi:10.1128/jvi.02493-10 · Cited by 187 · see citing works

E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands

Hofmann, M., & Pircher, H. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1107200108 · Cited by 173 · see citing works

Cutting Edge: Identification of E-Cadherin as a Ligand for the Murine Killer Cell Lectin-Like Receptor G1

Gründemann, C., Bauer, M., Schweier, O., von Oppen, N., Lässing, U., Saudan, P., Becker, K., Karp, K., Hanke, T., Bachmann, M. F., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1311 · Cited by 169 · see citing works

Aryl Hydrocarbon Receptor Is Critical for Homeostasis of Invariant γδ T Cells in the Murine Epidermis

Kadow, S., Jux, B., Zahner, S. P., Wingerath, B., Chmill, S., Clausen, B. E., Hengstler, J. G., & Esser, C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100912 · Cited by 146 · see citing works

Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses

Çuburu, N., Graham, B. S., Buck, C. B., Kines, R. C., Pang, Y.-Y. S., Day, P. M., Lowy, D. R., & Schiller, J. T. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63287 · Cited by 140 · see citing works

Direct Evidence for Interferon-γ Production by Effector-Memory-Type Intraepidermal T Cells Residing at an Effector Site of Immunopathology in Fixed Drug Eruption

Mizukawa, Y., Yamazaki, Y., Teraki, Y., Hayakawa, J., Hayakawa, K., Nuriya, H., Kohara, M., & Shiohara, T. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64410-0 · Cited by 125 · see citing works

Long-Term Persistence of Activated Cytotoxic T Lymphocytes after Viral Infection of the Central Nervous System

Hawke, S. H., Stevenson, P. G., Freeman, S., & Bangham, C. R. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.10.1575 · Cited by 105 · see citing works

Tissue-Resident T Cells: Dynamic Players in Skin Immunity

Mueller, S. N., Zaid, A., & Carbone, F. R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00332 · Cited by 90 · see citing works

Preexisting High Frequencies of Memory CD8+ T Cells Favor Rapid Memory Differentiation and Preservation of Proliferative Potential upon Boosting

Fraser, K. A., Schenkel, J. M., Jameson, S. C., Vezys, V., & Masopust, D. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.003 · Cited by 89 · see citing works

Intra- and Intercompartmental Movement of γδ T Cells: Intestinal Intraepithelial and Peripheral γδ T Cells Represent Exclusive Nonoverlapping Populations with Distinct Migration Characteristics

Chennupati, V., Worbs, T., Liu, X., Malinarich, F. H., Schmitz, S., Haas, J. D., Malissen, B., Förster, R., & Prinz, I. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001652 · Cited by 84 · see citing works

Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites

Tse, S., Cockburn, I., Zhang, H., Scott, A., & Zavala, F. (2013) · Genes and Immunity · doi:10.1038/gene.2013.20 · Cited by 83 · see citing works

Maintenance of T Cell Function in the Face of Chronic Antigen Stimulation and Repeated Reactivation for a Latent Virus Infection

Mackay, L. K., Wakim, L. M., van Vliet, C., Jones, C. M., Mueller, S. N., Bannard, O., Fearon, D. T., Heath, W. R., & Carbone, F. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102719 · Cited by 78 · see citing works

Generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR

Sowell, R., Rogozinska, M., Nelson, C. E., Vezys, V., & Marzo, A. (2014) · Journal of Immunology · doi:10.4049/jimmunol.1400074 · Cited by 71 · see citing works

Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure

Ugur, M., Schulz, O., Menon, M., Krueger, A., & Pabst, O. (2014) · Nature Communications · doi:10.1038/ncomms5821 · Cited by 69 · see citing works

Smad4 Promotes Differentiation of Effector and Circulating Memory CD8 T Cells but Is Dispensable for Tissue-Resident Memory CD8 T Cells

Hu, Y., Lee, Y., Kaech, S. M., Garvy, B. A., & Cauley, L. S. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402369 · Cited by 59 · see citing works

Thymus‐resident memory CD8+ T cells mediate local immunity

Hofmann, M., Oschowitzer, A., Kurzhals, S., Krüger, C., & Pircher, H. (2013) · European Journal of Immunology · doi:10.1002/eji.201343519 · Cited by 45 · see citing works

Naive CD4+ T Lymphocytes Circulate through Lymphoid Organs To Interact with Endogenous Antigens and Upregulate Their Function

Tomura, M., Itoh, K., & Kanagawa, O. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903946 · Cited by 40 · see citing works

Memory T Cells Generated by Prior Exposure to Influenza Cross React with the Novel H7N9 Influenza Virus and Confer Protective Heterosubtypic Immunity

McMaster, S. R., Gabbard, J. D., Koutsonanos, D. G., Compans, R. W., Tripp, R. A., Tompkins, S. M., & Kohlmeier, J. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115725 · Cited by 32 · see citing works

Homeostatic cytokines orchestrate the segregation of CD4 and CD8 memory T-cell reservoirs in mice.

Yang, L.-L., Yu, Y., Kalwani, M., Tseng, T.-W. J., & Baltimore, D. (2011) · Blood · doi:10.1182/blood-2011-04-349746 · Cited by 24 · see citing works

Post-transcriptional regulation of E2A proteins via lipopolysaccharide and CD40 signaling

Meyer, K. B., & Mufti, D. A. H. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200002)30:2 · Cited by 8 · see citing works

Innate Lymphoid Cells: 10 Years On

Vivier, É., Artis, D., Colonna, M., Diefenbach, A., Santo, J. P. D., Eberl, G., Koyasu, S., Locksley, R. M., McKenzie, A. N. J., Mebius, R. E., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.017 · Cited by 2,136 · see citing works

Human T cell development, localization, and function throughout life

Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257 · see citing works

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

Kumar, B. V., Ma, W., Miron, M., Granot, T., Guyer, R. S., Carpenter, D. J., Senda, T., Sun, X., Ho, S.-H., Lerner, H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.078 · Cited by 1,068 · see citing works

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

Blass, E., & Ott, P. A. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00460-2 · Cited by 1,042 · see citing works

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Savas, P., Virassamy, B., Ye, C., Salim, A., Mintoff, C. P., Caramia, F., Salgado, R., Byrne, D. J., Teo, Z. L., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0078-7 · Cited by 992 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 982 · see citing works

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Duhen, T., Duhen, R., Montler, R., Moses, J., Moudgil, T., de Miranda, N. F., Goodall, C. P., Blair, T. C., Fox, B. A., McDermott, J. E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05072-0 · Cited by 938 · see citing works

Mucosal vaccines — fortifying the frontiers

Lavelle, E. C., & Ward, R. W. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00583-2 · Cited by 763 · see citing works

CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin

Cheuk, S., Schlums, H., Gallais Sérézal, I., Martini, E., Chiang, S. C., Marquardt, N., Gibbs, A., Detlofsson, E., Introini, A., Forkel, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.009 · Cited by 678 · see citing works

The multifaceted role of CD4+ T cells in CD8+ T cell memory

Laidlaw, B. J., Craft, J. E., & Kaech, S. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.10 · Cited by 657 · see citing works

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma

Schalper, K. A., Rodriguez-Ruiz, M. E., Díez-Valle, R., López‐Janeiro, Á., Porciuncula, A., Idoate, M. A., Inogés, S., de Andrea, C., de Cerio, A. L.-D., Tejada, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0339-5 · Cited by 645 · see citing works

Vitiligo: Mechanisms of Pathogenesis and Treatment

Frisoli, M. L., Essien, K. I., & Harris, J. E. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-100919-023531 · Cited by 621 · see citing works

Cutaneous leishmaniasis: Immune responses in protection and pathogenesis

Scott, P., & Novais, F. O. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.72 · Cited by 591 · see citing works

Resistance to PD1/PDL1 checkpoint inhibition

O’Donnell, J. S., Long, G. V., Scolyer, R. A., Teng, M. W. L., & Smyth, M. J. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.11.007 · Cited by 574 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies *

Cossarizza, A., Chang, H., Radbruch, A., Akdiş, M., Andrä, I., Annunziato, F., Bächer, P., Barnaba, V., Battistini, L., Bauer, W. M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646632 · Cited by 572 · see citing works

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

Machado-Santos, J., Saji, E., Tröscher, A. R., Paunovic, M., Liblau, R., Gabriely, G., Bien, C. G., Bauer, J., & Lassmann, H. (2018) · Brain · doi:10.1093/brain/awy151 · Cited by 548 · see citing works

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry

Winkels, H., Ehinger, E., Vassallo, M., Buscher, K., Dinh, H. Q., Kobiyama, K., Hamers, A. A. J., Cochain, C., Vafadarnejad, E., Saliba, A.-E., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312513 · Cited by 547 · see citing works

Dynamics and specificities of T cells in cancer immunotherapy

Oliveira, G., & Wu, C. (2023) · Nature Reviews. Cancer · doi:10.1038/s41568-023-00560-y · Cited by 495 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works

Understanding subset diversity in T cell memory

Jameson, S. C., & Masopust, D. (2018) · Immunity · doi:10.1016/j.immuni.2018.02.010 · Cited by 523 · see citing works

High-dimensional, single-cell characterization of the brain's immune compartment

Korin, B., Ben-Shaanan, T. L., Schiller, M., Dubovik, T., Azulay‐Debby, H., Boshnak, N., Koren, T., & Rolls, A. (2017) · Nature Neuroscience · doi:10.1038/nn.4610 · Cited by 423 · see citing works

The spectrum of T cell metabolism in health and disease

Bantug, G. R., Galluzzi, L., Kroemer, G., & Hess, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.99 · Cited by 421 · see citing works

Tissue-resident memory T cells populate the human brain

Smolders, J., Heutinck, K. M., Fransen, N. L., Remmerswaal, E. B. M., Hombrink, P., ten Berge, I. J. M., van Lier, R. A. W., Huitinga, I., & Hamann, J. (2018) · Nature Communications · doi:10.1038/s41467-018-07053-9 · Cited by 406 · see citing works

Overcoming TGFβ-mediated immune evasion in cancer

Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00413-6 · Cited by 377 · see citing works

Immune and neuroendocrine mechanisms of stress vulnerability and resilience

Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374 · see citing works

PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

Ma, J., Zheng, B., Goswami, S., Lu, M., Zhang, D., Cao, C., Li, T., Zhu, F., Ma, L., Zhang, Z., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0814-7 · Cited by 364 · see citing works

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

Bourdely, P., Anselmi, G., Vaivode, K., Ramos, R. N., Missolo-Koussou, Y., Hidalgo, S., Tosello, J., Núñez, N. G., Richer, W., Vincent‐Salomon, A., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.002 · Cited by 358 · see citing works

IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection

Pallett, L. J., Davies, J., Colbeck, E. J., Robertson, F., Hansi, N., Easom, N. J. W., Burton, A. R., Stegmann, K. A., Schurich, A., Swadling, L., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162115 · Cited by 347 · see citing works

The influence of skin microorganisms on cutaneous immunity

Belkaid, Y., & Tamoutounour, S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.48 · Cited by 336 · see citing works

Resident memory T cells, critical components in tumor immunology

Mami‐Chouaib, F., Blanc, C., Corgnac, S., Hans, S., Malenica, I., Granier, C., Tihy, I., & Tartour, É. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0399-6 · Cited by 328 · see citing works

The roles of tertiary lymphoid structures in chronic diseases

Sato, Y., Siliņa, K., van den Broek, M. F., Hirahara, K., & Yanagita, M. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00706-z · Cited by 328 · see citing works

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Park, S. L., Zaid, A., Hor, J. L., Christo, S. N., Prier, J. E., Davies, B., Alexandre, Y. O., Gregory, J. L., Russell, T., Gebhardt, T., et al. (2018) · Nature Immunology · doi:10.1038/s41590-017-0027-5 · Cited by 317 · see citing works

Designing spatial and temporal control of vaccine responses

Roth, G. A., Picece, V. C. T. M., Ou, B. S., Luo, W., Pulendran, B., & Appel, E. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00372-2 · Cited by 328 · see citing works

CD8+ T cells in HIV control, cure and prevention

Collins, D. R., Gaiha, G. D., & Walker, B. D. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0274-9 · Cited by 305 · see citing works

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

Enamorado, M., Iborra, S., Priego, E., Cueto, F. J., Quintana, J. A., Martínez-Cano, S., Mejías‐Pérez, E., Estéban, M., Melero, I., Hidalgo, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms16073 · Cited by 295 · see citing works

T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy

Sharabi, A., & Tsokos, G. C. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0356-x · Cited by 291 · see citing works

Resident memory CD8+ T cells in the upper respiratory tract prevent pulmonary influenza virus infection

Pizzolla, A., Nguyen, T. H. O., Smith, J. M., Brooks, A., Kedzierska, K., Heath, W., Reading, P., & Wakim, L. (2017) · Science immunology · doi:10.1126/sciimmunol.aam6970 · Cited by 284 · see citing works

Generation and persistence of human tissue-resident memory T cells in lung transplantation

Snyder, M. E., Finlayson, M. O., Connors, T. J., Dogra, P., Senda, T., Bush, E. C., Carpenter, D. J., Marboe, C. C., Benvenuto, L. J., Shah, L., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav5581 · Cited by 281 · see citing works

Tissue-resident memory T cells at the center of immunity to solid tumors

Amsen, D., van Gisbergen, K. P. J. M., Hombrink, P., & van Lier, R. A. W. (2018) · Nature Immunology · doi:10.1038/s41590-018-0114-2 · Cited by 278 · see citing works

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

Collins, N., Han, S., Enamorado, M., Link, V. M., Huang, B., Moseman, E. A., Kishton, R. J., Shannon, J. P., Dixit, D., Schwab, S. R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.049 · Cited by 273 · see citing works

Contradictory roles of lipid metabolism in immune response within the tumor microenvironment

Yu, W., Lei, Q., Yang, L., Qin, G., Liu, S., Wang, D., Ping, Y., & Zhang, Y. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01200-4 · Cited by 272 · see citing works

Human CD4 + CD103 + cutaneous resident memory T cells are found in the circulation of healthy individuals

Klicznik, M. M., Morawski, P. A., Höllbacher, B., Varkhande, S. R., Motley, S., Kuri-Cervantes, L., Goodwin, E. C., Rosenblum, M. D., Long, S. A., Brachtl, G., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav8995 · Cited by 251 · see citing works

Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory

Beura, L., Mitchell, J. S., Thompson, E., Schenkel, J., Mohammed, J., Wijeyesinghe, S. P., Fonseca, R., Burbach, B., Hickman, H., Vezys, V., et al. (2018) · Nature Immunology · doi:10.1038/s41590-017-0029-3 · Cited by 248 · see citing works

Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands

Cortez, V. S., Cervantes‐Barragán, L., Robinette, M. L., Bando, J. K., Wang, Y., Geiger, T. L., Gilfillan, S., Fuchs, A. G., Vivier, É., Sun, J. C., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.03.007 · Cited by 255 · see citing works

Single-cell atlas of colonic CD8+ T cells in ulcerative colitis

Corridoni, D., Antanaviciute, A., Gupta, T., Fawkner-Corbett, D., Aulicino, A., Jagielowicz, M., Parikh, K., Repapi, E., Taylor, S. L., Ishikawa, D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1003-4 · Cited by 252 · see citing works

Mucosal BCG Vaccination Induces Protective Lung-Resident Memory T Cell Populations against Tuberculosis

Perdomo, C., Zedler, U., Kühl, A. A., Lozza, L., Saikali, P., Sander, L. E., Vogelzang, A., Kaufmann, S. H. E., & Kupz, A. (2016) · mBio · doi:10.1128/mbio.01686-16 · Cited by 254 · see citing works

White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection

Han, S., Zaretsky, A. G., Andrade‐Oliveira, V., Collins, N., Dzutsev, A. H., Shaik, J. S., da Fonseca, D. M., Harrison, O. J., Tamoutounour, S., Byrd, A. L., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.11.009 · Cited by 250 · see citing works

Two to Tango: Dialog between Immunity and Stem Cells in Health and Disease

Naik, S., Larsen, S. B., Cowley, C. J., & Fuchs, E. V. (2018) · Cell · doi:10.1016/j.cell.2018.08.071 · Cited by 249 · see citing works

The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection

Gallo, O., Locatello, L. G., Mazzoni, A., Novelli, L., & Annunziato, F. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00359-2 · Cited by 246 · see citing works

Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing

Kakaradov, B., Arsenio, J., Widjaja, C. E., He, Z., Aigner, S., Metz, P. J., Yu, B., Wehrens, E. J., Lopez, J. M., Kim, S. H., et al. (2017) · Nature Immunology · doi:10.1038/ni.3688 · Cited by 231 · see citing works

Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation

Zundler, S., Becker, E., Spocinska, M., Slawik, M., Parga-Vidal, L., Stark, R., Wiendl, M., Atreya, R., Rath, T., Leppkes, M., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0298-5 · Cited by 226 · see citing works

Fatty Acid Oxidation Controls CD8+ Tissue-Resident Memory T-cell Survival in Gastric Adenocarcinoma

Lin, R., Zhang, H., Yuan, Y., He, Q., Zhou, J., Li, S., Sun, Y., Li, D. Y., Qiu, H.-B., Wang, W., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0702 · Cited by 237 · see citing works

Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

Virassamy, B., Caramia, F., Savas, P. S., Sant, S. A., Wang, J., Christo, S. N., Byrne, A., Clarke, K. A., Brown, E., Teo, Z. L., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.01.004 · Cited by 234 · see citing works

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

Hegde, P., Weiss, E., Paradis, V., Wan, J., Mabire, M., Sukriti, S., Rautou, P.-E., Albuquerque, M., Picq, O., Gupta, A. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04450-y · Cited by 232 · see citing works

Sex Drives Dimorphic Immune Responses to Viral Infections

Ghosh, S., & Klein, R. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601166 · Cited by 232 · see citing works

The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues

Kok, L., Masopust, D., & Schumacher, T. N. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00590-3 · Cited by 230 · see citing works

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions

Fransen, N. L., Hsiao, C., van der Poel, M., Engelenburg, H. J., Verdaasdonk, K., Vincenten, M. C. J., Remmerswaal, E. B. M., Kuhlmann, T., Mason, M. R. J., Hamann, J., et al. (2020) · Brain · doi:10.1093/brain/awaa117 · Cited by 229 · see citing works

Early precursors and molecular determinants of tissue-resident memory CD8 + T lymphocytes revealed by single-cell RNA sequencing

Kurd, N. S., He, Z., Louis, T. L., Milner, J. J., Omilusik, K. D., Jin, W., Tsai, M. S., Widjaja, C. E., Kanbar, J. N., Olvera, J. G., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz6894 · Cited by 209 · see citing works

Migratory DCs activate TGF-β to precondition naïve CD8 + T cells for tissue-resident memory fate

Mani, V., Bromley, S. K., Äijö, T., Mora‐Buch, R., Carrizosa, E., Warner, R. D., Hamze, M., Sen, D. R., Chasse, A. Y., Lorant, A. K., et al. (2019) · Science · doi:10.1126/science.aav5728 · Cited by 219 · see citing works

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Christo, S. N., Evrard, M., Park, S. L., Gandolfo, L. C., Burn, T. N., Fonseca, R., Newman, D. M., Alexandre, Y. O., Collins, N., Zamudio, N., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01004-1 · Cited by 218 · see citing works

Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1 + Dendritic Cells

Iborra, S., Martínez‐López, M., Khouili, S. C., Enamorado, M., Cueto, F. J., Conde‐Garrosa, R., del Fresno, C., & Sancho, D. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.019 · Cited by 217 · see citing works

MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells

Jones, R. G., & Pearce, E. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.028 · Cited by 214 · see citing works

Mathematical Models for Immunology: Current State of the Art and Future Research Directions

Eftimie, R., Gillard, J. J., & Cantrell, D. A. (2016) · Bulletin of Mathematical Biology · doi:10.1007/s11538-016-0214-9 · Cited by 213 · see citing works

Tissue-resident CD4 + T helper cells assist the development of protective respiratory B and CD8 + T cell memory responses

Son, Y. M., Cheon, I. S., Wu, Y., Li, C., Wang, Z., Gao, X., Chen, Y., Takahashi, Y., Fu, Y., Dent, A. L., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abb6852 · Cited by 210 · see citing works

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

Schreurs, R., Baumdick, M. E., Sagebiel, A. F., Kaufmann, M., Mokrý, M., Klarenbeek, P. L., Schaltenberg, N., Steinert, F. L., van Rijn, J. M., Drewniak, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.010 · Cited by 206 · see citing works

Skin Wound Healing: Of Players, Patterns, and Processes

Sorg, H., & Sorg, C. G. G. (2022) · European Surgical Research · doi:10.1159/000528271 · Cited by 189 · see citing works

Pathophysiology of psoriasis: A review

Yamanaka, K., Yamamoto, O., & Honda, T. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.15913 · Cited by 204 · see citing works

Transcriptional Regulation of Tissue-Resident Lymphocytes

Mackay, L. K., & Kallies, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.11.004 · Cited by 196 · see citing works

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

Mayassi, T., Ladell, K., Gudjonson, H., McLaren, J. E., Shaw, D. G., Tran, M. T., Rokicka, J. J., Lawrence, I., Grenier, J., van Unen, V., et al. (2019) · Cell · doi:10.1016/j.cell.2018.12.039 · Cited by 190 · see citing works

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

Park, S. L., Gebhardt, T., & Mackay, L. K. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.06.002 · Cited by 190 · see citing works

Tissue resident memory T cells in the respiratory tract

Zheng, M. Z. M., & Wakim, L. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00461-z · Cited by 177 · see citing works

Diverse developmental pathways of intestinal intraepithelial lymphocytes

McDonald, B. D., Jabri, B., & Bendelac, A. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0013-7 · Cited by 190 · see citing works

Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses

Behr, F. M., Parga-Vidal, L., Kragten, N. A. M., van Dam, T. J. P., Wesselink, T. H., Sheridan, B. S., Arens, R., van Lier, R. A. W., Stark, R., & van Gisbergen, K. P. J. M. (2020) · Nature Immunology · doi:10.1038/s41590-020-0723-4 · Cited by 184 · see citing works

The function and dysfunction of memory CD 8+ T cells in tumor immunity

Reading, J. L., Gálvez‐Cancino, F., Swanton, C., Lladser, Á., Peggs, K. S., & Quezada, S. A. (2018) · Immunological Reviews · doi:10.1111/imr.12657 · Cited by 182 · see citing works

Hallmarks of the aging T‐cell system

Zhang, H., Weyand, C. M., & Goronzy, J. J. (2021) · FEBS Journal · doi:10.1111/febs.15770 · Cited by 177 · see citing works

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

Pizzolla, A., Nguyen, T. H. O., Sant, S. A., Jaffar, J., Loudovaris, T., Mannering, S. I., Thomas, P. G., Westall, G. P., Kedzierska, K., & Wakim, L. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96957 · Cited by 181 · see citing works

Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells

Anadon, C. M., Yu, X., Hänggi, K., Biswas, S., Chaurio, R. A., Martin, A., Payne, K. K., Mandal, G., Innamarato, P., Harro, C. M., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.03.008 · Cited by 174 · see citing works

MMP (Matrix Metalloprotease)-9–Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis

Watanabe, R., Maeda, T., Zhang, H., Berry, G. J., Zeisbrich, M., Brockett, R., Greenstein, A. E., Tian, L., Goronzy, J. J., & Weyand, C. M. (2018) · Circulation Research · doi:10.1161/circresaha.118.313206 · Cited by 169 · see citing works

Influenza virus-specific CD4+ and CD8+ T cell-mediated immunity induced by infection and vaccination

Jansen, J. M., Gerlach, T. H., Elbahesh, H., Rimmelzwaan, G. F., & Saletti, G. (2019) · Journal of Clinical Virology · doi:10.1016/j.jcv.2019.08.009 · Cited by 168 · see citing works

Chemokine Receptor–Dependent Control of Skin Tissue–Resident Memory T Cell Formation

Zaid, A., Hor, J. L., Christo, S. N., Groom, J. R., Heath, W. R., Mackay, L. K., & Mueller, S. N. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700571 · Cited by 162 · see citing works

Local Inflammatory Cues Regulate Differentiation and Persistence of CD8+ Tissue-Resident Memory T Cells

Bergsbaken, T., Bevan, M. J., & Fink, P. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.031 · Cited by 161 · see citing works

Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis

Wilk, M. M., Misiak, A., McManus, R. M., Allen, A. C., Lynch, M. A., & Mills, K. H. G. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602051 · Cited by 161 · see citing works

Trigger-happy resident memory CD4+ T cells inhabit the human lungs

Oja, A. E., Piet, B., Helbig, C., Stark, R., van der Zwan, D., Blaauwgeers, H., Remmerswaal, E. B. M., Amsen, D., Jonkers, R. E., Moerland, P. D., et al. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.94 · Cited by 160 · see citing works

Neuroinflammation During RNA Viral Infections

Klein, R. S., Garber, C., Funk, K. E., Salimi, H., Soung, A., Kanmogne, M., Manivasagam, S., Agner, S., & Cain, M. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041417 · Cited by 160 · see citing works

Bystander T cells in cancer immunology and therapy

Meier, S. L., Satpathy, A. T., & Wells, D. K. (2022) · Nature Cancer · doi:10.1038/s43018-022-00335-8 · Cited by 157 · see citing works

Choline acetyltransferase-expressing T cells are required to control chronic viral infection

Cox, M. A., Duncan, G. S., Lin, G. H. Y., Steinberg, B. E., Yu, L. X., Brenner, D., Buckler, L. N., Elia, A. J., Wakeham, A. C., Nieman, B., et al. (2019) · Science · doi:10.1126/science.aau9072 · Cited by 155 · see citing works

T Cell Trafficking through Lymphatic Vessels

Hunter, M. C., Teijeira, Á., & Halin, C. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00613 · Cited by 154 · see citing works

Neurobiology of resilience in depression: immune and vascular insights from human and animal studies

Dudek, K., Dion‐Albert, L., Kaufmann, F. N., Tuck, E., Lebel, M., & Ménard, C. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14547 · Cited by 156 · see citing works

Restoring, releasing or replacing adaptive immunity in chronic hepatitis B

Maini, M. K., & Burton, A. R. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0196-9 · Cited by 152 · see citing works

Inflammaging is associated with shifted macrophage ontogeny and polarization in the aging mouse ovary

Zhang, Z., Schlamp, F., Huang, L., Clark, H., & Brayboy, L. (2020) · Reproduction · doi:10.1530/rep-19-0330 · Cited by 150 · see citing works

Fatty acid metabolism in CD 8 + T cell memory: Challenging current concepts

Raud, B., McGuire, P. J., Jones, R. G., Sparwasser, T. D., & Berod, L. (2018) · Immunological Reviews · doi:10.1111/imr.12655 · Cited by 150 · see citing works

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

Banchereau, R., Chitre, A. S., Scherl, A., Wu, T. D., Patil, N. S., de Almeida, P. E., Kadel, E. E., Madireddi, S., Au‐Yeung, A., Takahashi, C., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002231 · Cited by 148 · see citing works

Immune cell trafficking and retention in inflammatory bowel disease: mechanistic insights and therapeutic advances

Zundler, S., Becker, E., Schulze, L. L., & Neurath, M. F. (2019) · Gut · doi:10.1136/gutjnl-2018-317977 · Cited by 144 · see citing works

Regulation of Innate and Adaptive Immunity by TGFβ

Kelly, A., Houston, S. A., Sherwood, E., Casulli, J., & Travis, M. A. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.01.001 · Cited by 142 · see citing works

Bystander CD4+ T cells: crossroads between innate and adaptive immunity

Lee, H., Cho, M.-J., & Choi, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00486-7 · Cited by 142 · see citing works

Pathophysiology of Skin Resident Memory T Cells

TOKURA, Y., Phadungsaksawasdi, P., Kurihara, K., Fujiyama, T., & Honda, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.618897 · Cited by 142 · see citing works

Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma

Cheng, Y., Gunasegaran, B., Singh, H. D., Dutertre, C.-A., Loh, C. Y., Lim, J. Q., Crawford, J. C., Lee, H. K., Zhang, X., Lee, B., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.06.013 · Cited by 142 · see citing works

Tissue resident memory T cells and viral immunity

Rosato, P. C., Beura, L. K., & Masopust, D. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.11.011 · Cited by 137 · see citing works

Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis

Kokubo, K., Onodera, A., Kiuchi, M., Tsuji, K., Hirahara, K., & Nakayama, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945063 · Cited by 130 · see citing works

Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites

MacLean, A. J., Richmond, N., Koneva, L. A., Attar, M., Prada‐Medina, C. A., Thornton, E. E., Gomes, A. C., El-Turabi, A., Bachmann, M. F., Rijal, P., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.03.003 · Cited by 131 · see citing works

The Multifaceted Role of Tissue-Resident Memory T Cells.

Christo, S., Park, S. L., Mueller, S. N., & Mackay, L. K. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-020220 · Cited by 120 · see citing works

Tissue‐resident memory T cells

Shin, H., & Iwasaki, A. (2013) · Immunological Reviews · doi:10.1111/imr.12087 · Cited by 206 · see citing works

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