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Continuous‐Flow Microreactor Chemistry under High‐Temperature/Pressure Conditions
Abstract
High‐temperature organic synthesis can be performed under continuous‐flow conditions in a stainless steel microtubular flow reactor capable of achieving temperatures of 350 °C and 200 bar. Under these extreme experimental environments transformations normally performed in a high‐boiling solvent at reflux temperature – or under sealed‐vessel microwave conditions – can be readily converted to a flow regime by using lower boiling solvents in or near their supercritical state.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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Cited by
The Hitchhiker’s Guide to Flow Chemistry
Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00183 · Cited by 1,995
Continuous flow reactors: a perspective
Wiles, C., & Watts, P. (2012) · Green Chem. · doi:10.1039/c1gc16022b · Cited by 626
Britton, J., Majumdar, S., & Weiss, G. A. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00906b · Cited by 389
Metadata
- Authors
- Razzaq, T., Glasnov, T. N., & Kappe, C. O.
- Venue
- European Journal of Organic Chemistry
- Publisher
- Wiley
- Published
- 2009-03
- Volume
- 2009
- Issue
- 9
- Pages
- 1321-1325
- ISSN
- 1099-0690 (ISSN-L)
- 1434-193X
- OpenAlex
- W1996958456
- Cited by
- 165
- References
- 0
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Razzaq, T., Glasnov, T. N., & Kappe, C. O. (2009). Continuous‐Flow Microreactor Chemistry under High‐Temperature/Pressure Conditions. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.200900077
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