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Organocatalyzed Asymmetric Friedel–Crafts Reactions

Terrasson, Vincent, Marcia de Figueiredo, Renata, Campagne, Jean Marc·2010·European Journal of Organic Chemistry

Abstract

Aromatic substitution enables the synthesis of relevant and promising biological entities through the direct synthesis of a range of highly functionalized compounds. Thus, since its discovery and over more than one century, the Friedel–Crafts (F‐C) alkylation has been used for carrying out such a transformation. Despite its aptitude and viability for aromatic substitutions, it is quite surprisingly that catalytic and asymmetric versions of F‐C reactions have only been described in the mid‐1980s. In this microreview, we are planning to underscore the main and recent developments in organocatalyzed F‐C reactions which were published within the 2001–2009 timeframe.

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Authors
Terrasson, V., Marcia de Figueiredo, R., & Campagne, J. M.
Venue
European Journal of Organic Chemistry
Publisher
Wiley
Published
2010-04-27
Volume
2010
Issue
14
Pages
2635-2655
ISSN
  • 1099-0690 (ISSN-L)
  • 1434-193X
OpenAlex
W2119984183
Cited by
286
References
0
FWCI
16.58
Type
journal article
Language
en
Open access
closed

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