The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Recent Developments in Amide Synthesis: Direct Amidation of Carboxylic Acids and Transamidation Reactions
Abstract
The synthesis of amides is of huge importance in a wide variety of industrial and academic fields and is of particular significance in the synthesis of pharmaceuticals. Many of the well established methods for amide synthesis involve reagents that are difficult to handle and lead to the generation of large quantities of waste products. As a consequence, there has been a considerable amount of interest in the development of new approaches to amide synthesis. Over the past few years a wide range of new reagents and catalysts for direct amidation of carboxylic acids have been reported. In addition, the interconversion of amide derivatives through transamidation is emerging as a potential alternative strategy for accessing certain amides. This microreview covers recent developments in the direct amidation of carboxylic acids and the interconversion of amides through transamidation. The advantages and disadvantages of the various methods are discussed, as well as the possible mechanisms of the reactions.
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Cites
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Amide bond formation: beyond the myth of coupling reagents
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Rethinking amide bond synthesis
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Analysis of the reactions used for the preparation of drug candidate molecules
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Amide bond formation and peptide coupling
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Key green chemistry research areas—a perspective from pharmaceutical manufacturers
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Metal-catalysed approaches to amide bond formation
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3,4,5-Trifluorobenzeneboronic Acid as an Extremely Active Amidation Catalyst
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Cited by
Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals
Dunetz, J. R., Magano, J., & Weisenburger, G. A. (2016) · Organic Process Research & Development · doi:10.1021/op500305s · Cited by 819
Mechanochemistry for Organic Chemists: An Update
Tan, D., & Friščić, T. (2018) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201700961 · Cited by 357
Landeros, J. M., & Juaristi, E. (2017) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201601276 · Cited by 48
Metadata
- Authors
- Lanigan, R. M., & Sheppard, T. D.
- Venue
- European Journal of Organic Chemistry
- Publisher
- Wiley
- Published
- 2013-08-06
- Volume
- 2013
- Issue
- 33
- Pages
- 7453-7465
- ISSN
- 1099-0690 (ISSN-L)
- 1434-193X
- OpenAlex
- W1607440177
- Cited by
- 428
- References
- 23
- FWCI
- 12.95
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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