The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Elicitation: A biotechnological tool for enhanced production of secondary metabolites in hairy root cultures
Open accessAbstract
Elicitation is a possible aid to overcome various difficulties associated with the large‐scale production of most commercially important bioactive secondary metabolites from wild and cultivated plants, undifferentiated or differentiated cultures. Secondary metabolite accumulation in vitro or their efflux in culture medium has been elicited in the undifferentiated or differentiated tissue cultures of several plant species by the application of a low concentration of biotic and abiotic elicitors in the last three decades. Hairy root cultures are preferred for the application of elicitation due to their genetic and biosynthetic stability, high growth rate in growth regulator‐free media, and production consistence in response to elicitor treatment. Elicitors act as signal, recognized by elicitor‐specific receptors on the plant cell membrane and stimulate defense responses during elicitation resulting in increased synthesis and accumulation of secondary metabolites. Optimization of various parameters, such as elicitor type, concentration, duration of exposure, and treatment schedule is essential for the effectiveness of the elicitation strategies. Combined application of different elicitors, integration of precursor feeding, or replenishment of medium or in situ product recovery from the roots/liquid medium with the elicitor treatment have showed improved accumulation of secondary metabolites due to their synergistic effect. This is a comprehensive review about the progress in the elicitation approach to hairy root cultures from 2010 to 2019 and the information provided is valuable and will be of interest for scientists working in this area of plant biotechnology.
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Cites
Influence of abiotic stress signals on secondary metabolites in plants
Akula, R., & Ravishankar, G. A. (2011) · Plant Signaling & Behavior · doi:10.4161/psb.6.11.17613 · Cited by 2,516
Ramirez-Estrada, K., Vidal-Limon, H., Hidalgo, D., Moyano, E., Golenioswki, M., Cusidó, R., & Palazon, J. (2016) · Molecules · doi:10.3390/molecules21020182 · Cited by 608
(2007) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · Cited by 522
Molecular aspects of the early stages of elicitation of secondary metabolites in plants
Vasconsuelo, A., & Boland, R. (2007) · Plant Science · doi:10.1016/j.plantsci.2007.01.006 · Cited by 385
Asgari Lajayer, B., Ghorbanpour, M., & Nikabadi, S. (2017) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2017.07.035 · Cited by 385
Production of Secondary Metabolites Using Plant Cell Cultures
Smetanska, I. (2008) · Advances in Biochemical Engineering/Biotechnology · doi:10.1007/10_2008_103 · Cited by 366
Genetically transformed roots: from plant disease to biotechnological resource
Georgiev, M. I., Agostini, E., Ludwig-Müller, J., & Xu, J. (2012) · Trends in Biotechnology · doi:10.1016/j.tibtech.2012.07.001 · Cited by 215
The multiplicity of hairy root cultures: Prolific possibilities
Ono, N. N., & Tian, L. (2011) · Plant Science · doi:10.1016/j.plantsci.2010.11.012 · Cited by 215
Engineering secondary metabolite production in hairy roots
Chandra, S., & Chandra, R. (2011) · Phytochemistry Reviews · doi:10.1007/s11101-011-9210-8 · Cited by 201
Zhai, X., Jia, M., Chen, L., Zheng, C.-J., Rahman, K., Han, T., & Qin, L.-P. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1201041 · Cited by 190
Cited by
Production of secondary metabolites using tissue culture-based biotechnological applications
Ozyigit, I. I., Dogan, I., Hocaoglu-Ozyigit, A., Yalcin, B., Erdogan, A., Yalcin, I. E., Cabi, E., & Kaya, Y. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1132555 · Cited by 261
Flavonoids: A Myth or a Reality for Cancer Therapy?
Forni, C., Rossi, M., Borromeo, I., Feriotto, G., Platamone, G., Tabolacci, C., Mischiati, C., & Beninati, S. (2021) · Molecules · doi:10.3390/molecules26123583 · Cited by 79
Khalili Hassanabad, M., Mirjalili, M. H., & Mohajeri, M. (2025) · Industrial Crops and Products · doi:10.1016/j.indcrop.2025.120796 · Cited by 9
Metadata
- Authors
- Halder, M., Sarkar, S., & Jha, S.
- Venue
- Engineering in Life Sciences
- Publisher
- Wiley
- Published
- 2019-07-25
- Volume
- 19
- Issue
- 12
- Pages
- 880-895
- ISSN
- 1618-0240 (ISSN-L)
- 1618-2863
- OpenAlex
- W2960723775
- Cited by
- 353
- References
- 55
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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