Flavonoids: A Myth or a Reality for Cancer Therapy?
Open accessAbstract
Nutraceuticals are biologically active molecules present in foods; they can have beneficial effects on health, but they are not available in large enough quantities to perform this function. Plant metabolites, such as polyphenols, are widely diffused in the plant kingdom, where they play fundamental roles in plant development and interactions with the environment. Among these, flavonoids are of particular interest as they have significant effects on human health. In vitro and/or in vivo studies described flavonoids as essential nutrients for preventing several diseases. They display broad and promising bioactivities to fight cancer, inflammation, bacterial infections, as well as to reduce the severity of neurodegenerative and cardiovascular diseases or diabetes. Therefore, it is not surprising that interest in flavonoids has sharply increased in recent years. More than 23,000 scientific publications on flavonoids have described the potential anticancer activity of these natural molecules in the last decade. Studies, in vitro and in vivo, show that flavonoids exhibit anticancer properties, and many epidemiological studies confirm that dietary intake of flavonoids leads to a reduced risk of cancer. This review provides a glimpse of the mechanisms of action of flavonoids on cancer cells.
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Mindfulness training teaches individuals to disengage from automatic processing and redirect attention to present-moment goals such as breathing or sensation, preparing conditions for change.
“زض تثییي یافتِّای ایي هغالقِ هی تَاى گفت وِ آهَظـ شّي آگاّی تِ افطاز یاز هی زّس وِ چگًَِ هْاضت ّای فازتی ٍ غیط اًقغاف پصیط ضا اظ حالت تهلة ذاضد ٍ تا رْت زازى هٌاتـ پطزاظـ اعلافات تِ عطف اّساف ذٌخی تَرِ، هاًٌس تٌفؽ یا حؽ لحؾِ، قطایظ ضا تطای تغییط آهازُ وٌٌس.”
From Effectiveness of Mindfulness Training in Emotion Regulation and Distress Tolerance among Breast Cancer Patients (2024) · cites this paper as [57]
Section 2.7 discusses flavonoids and sensitivity to chemotherapy, while section 2.6 discusses cancer-cell differentiation; neither addresses mindfulness training. Searches for mindfulness, breathing, present-moment attention, and disengagement from automatic processing found no relevant passage in our copy. Page numbers were not available. (LLM, conf=0.78)
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Flagged first, then by citations
Research works printed but not linked: 1
- Middleton, 1984, The flavonoids, Trends Pharmacol. Sci., 5, 335
Cited by
Sorted by citations
Parsaee, S., Jahani, N., Salehiniya, H., & Raeison, M. (2024) · Journal of Breast Diseases · doi:10.61186/ijbd.17.1.84
- Authors
- Forni, C., Rossi, M., Borromeo, I., Feriotto, G., Platamone, G., Tabolacci, C., Mischiati, C., & Beninati, S.
- Affiliations
- University of Rome Tor Vergata (IT)
- University of Ferrara (IT)
- Istituto Superiore di Sanità (IT)
- Corresponding author
- Forni, Cinzia
- ORCID
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2021-06-11
- Volume
- 26
- Issue
- 12
- Pages
- 3583
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC8230897
- OpenAlex
- W3169797282
- Cited by
- 79
- References
- 120
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 18 · 2023: 19 · 2022: 17 · 2021: 3
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
- Funders
- Fondazione Umberto Veronesi
- Università degli Studi di Roma Tor Vergata
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Health Sciences › Medicine › Pharmacology › Synthesis of Organic Compounds
- Keywords
- flavonoids, anticancer activity, cancer therapy, polyphenols, plant metabolites, mechanism of action, dietary flavonoids, cancer prevention, inflammation, neurodegenerative diseases, cardiovascular disease, diabetes mellitus
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Antioxidants, Flavonoids, Humans, Inflammation, Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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