The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The social environment and the epigenome
Open accessAbstract
The genome is programmed by the epigenome. Two of the fundamental components of the epigenome are chromatin structure and covalent modification of the DNA molecule itself by methylation. DNA methylation patterns are sculpted during development and it has been a long held belief that they remain stable after birth in somatic tissues. Recent data suggest that DNA methylation is dynamic later in life in postmitotic cells such as neurons and thus potentially responsive to different environmental stimuli throughout life. We hypothesize a mechanism linking the social environment early in life and long‐term epigenetic programming of behavior and responsiveness to stress and health status later in life. We will also discuss the prospect that the epigenetic equilibrium remains responsive throughout life and that therefore environmental triggers could play a role in generating interindividual differences in human behavior later in life. We speculate that exposures to different environmental toxins alters long‐established epigenetic programs in the brain as well as other tissues leading to late‐onset disease. Environ. Mol. Mutagen., 2008. © 2007 Wiley‐Liss, Inc.
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“The demethylation activity is counterbalanced by the DNMTs recruited by repressing factors such as PML/RAR and EZH2.”
BackgroundInfluential
Cited by
The Lifelong Effects of Early Childhood Adversity and Toxic Stress
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How the Timing and Quality of Early Experiences Influence the Development of Brain Architecture
Fox, S. E., Levitt, P., & Nelson, C. A. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01380.x · Cited by 1,088
The Neurobiology of Human Attachments
Feldman, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.11.007 · Cited by 839
Metadata
- Authors
- Szyf, M., McGowan, P., & Meaney, M. J.
- Venue
- Environmental and Molecular Mutagenesis
- Publisher
- Wiley
- Published
- 2007-12-19
- Volume
- 49
- Issue
- 1
- Pages
- 46-60
- ISSN
- 0893-6692 (ISSN-L)
- 1098-2280
- OpenAlex
- W2109112922
- Cited by
- 531
- References
- 18
- FWCI
- 14.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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