Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21

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Items 101–170 of 170

  1. Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
    Sean J. Farley, Alla Grishok, Ella Zeldich · 2022 · Epigenetics & Chromatin
  2. Data in brief: Transcriptome analysis of induced pluripotent stem cells from monozygotic twins discordant for trisomy 21
    Youssef Hibaoui, Iwona Grad, Audrey Letourneau, Federico Andrea Santoni, Stylianos E. Antonarakis, Anis Féki · 2014 · Genomics Data
  3. Alzheimer’s disease like neuropathology in Down syndrome cortical organoids
    Helen Zhao, Gabriel George Haddad · 2022 · Frontiers in Cellular Neuroscience
  4. Concise Review: Methods and Cell Types Used to Generate Down Syndrome Induced Pluripotent Stem Cells
    Youssef Hibaoui, Anis Féki · 2015 · Journal of Clinical Medicine
  5. Investigating pediatric disorders with induced pluripotent stem cells
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  6. Modeling Klinefelter Syndrome Using Induced Pluripotent Stem Cells Reveals Impaired Germ Cell Differentiation
    Olivier Botman, Youssef Hibaoui, Maria Grazia Giudice, Jérôme Ambroise, Catherine Creppe, Anis Féki, Christine Wyns · 2020 · Frontiers in Cell and Developmental Biology
  7. Abnormalities of DYRK1A-Cytoskeleton Complexes in the Blood Cells as Potential Biomarkers of Alzheimer’s Disease
    Karol Dowjat, Tatyana Adayev, Urszula Wojda, Katarzyna Brzozowska, Anna K. Barczak, Tomasz Gabryelewicz, Yu‐Wen Hwang · 2019 · Journal of Alzheimer s Disease
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  9. One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage
    Beatrice Vione, Giuseppe Ramacieri, Giacomo Zavaroni, Angela Piano, Giorgia La Rocca, Maria Caracausi, Lorenza Vitale, Allison Piovesan, Caterina Gori, Gian Luca Pirazzoli et al. · 2022 · Frontiers in Medicine
  10. Single‐cell landscape analysis reveals systematic senescence in mammalian Down syndrome
    Yao Chen, Yanyu Xiao, Yanye Zhang, Renying Wang, Feixia Wang, Huajing Gao, Yifeng Liu, Runju Zhang, Huiyu Sun, Ziming Zhou et al. · 2023 · Clinical and Translational Medicine
  11. Exploratory analysis of the proteomic profile in plasma in adults with Down syndrome in the context of Alzheimer's disease
    Olivia Wagemann, Georg Nübling, Francisco J. Martínez-Murcia, Elisabeth Wlasich, Sandra Virginia Loosli, Katja Sandkühler, Anna Stockbauer, Catharina Prix, Sabrina Katzdobler, Agnese Petrera et al. · 2025 · Alzheimer s & Dementia
  12. Altered development of dopaminergic neurons differentiated from stem cells from human exfoliated deciduous teeth of a patient with Down syndrome
    Thanh Thi Mai Pham, Hiroki Kato, Haruyoshi Yamaza, Keiji Masuda, Yuta Hirofuji, Hiroshi Sato, Huong Thi Nguyen Nguyen, Xu Han, Yu Xin Zhang, Tomoaki Taguchi et al. · 2018 · BMC Neurology
  13. Neuronal Cell-Intrinsic Defects in Mouse Models of Down Syndrome
    Chiotto, Alessandra Maria Adelaide, Migliorero, Martina, Pallavicini, Gianmarco, Bianchi, Federico Tommaso, Gai, Marta, Di Cunto, Ferdinando, Berto, Gaia Elena · 2019 · Frontiers in Neuroscience
  14. Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem Cells
    Yohei Hayashi, Miho Takami, Mami Matsuo‐Takasaki · 2020 · Frontiers in Cellular Neuroscience
  15. Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome
    Ishihara, Keiichi · 2021 · Genes
  16. Influence of Microenvironmental Orchestration on Multicellular Lung Alveolar Organoid Development from Human Induced Pluripotent Stem Cells
    Vedat Burak Ozan, Huijuan Wang, Akshay Akshay, Deepika Anand, Youssef Hibaoui, Anis Féki, Janine Gote-Schniering, Ali Hashemi Gheinani, Manfred Heller, Anne‐Christine Uldry et al. · 2024 · Stem Cell Reviews and Reports
  17. Astrocytic Alterations and Dysfunction in Down Syndrome: Focus on Neurogenesis, Synaptogenesis, and Neural Circuits Formation
    Beatrice Uguagliati, Mariagrazia Grilli · 2024 · Cells
  18. Conducting Clinical Trials in Twin Populations: A Review of Design, Analysis, Recruitment and Ethical Issues for Twin-Only Trials
    Lisa Nicole Yelland, Katrina J. Scurrah, Paulo H. Ferreira, Lucas Calais‐Ferreira, Monica Rankin, Jane Denton, Merryl Harvey, Katherine J. Lee, Evie Shoshannah Kendal, Jeffrey Mark Craig · 2021 · Twin Research and Human Genetics
  19. Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome
    Campbell, Natalie Baker, Patel, Yesha, Moore, Tara L., Medalla, Maria, Zeldich, Ella · 2023 · International Journal of Molecular Sciences
  20. Generation of improved human cerebral organoids from single copy DYRK1A knockout induced pluripotent stem cells in trisomy 21: hypothetical solutions for neurodevelopmental models and therapeutic alternatives in down syndrome
    Elif Çağlayan · 2016 · Cell Biology International
  21. Measurement of synaptic density in Down syndrome using PET imaging: a pilot study
    Alexandra H DiFilippo, Erin McMullen Jonaitis, Renee Makuch, Brianna Piro‐Gambetti, Victoria Fleming, Gilda E. Ennis, Todd E. Barnhart, Jonathan W. Engle, Barbara B. Bendlin, Sterling C. Johnson et al. · 2024 · Scientific Reports
  22. Generation of a novel isogenic trisomy panel in human embryonic stem cells via microcell-mediated chromosome transfer
    Kei Hiramatsu, Satoshi Abe, Kanako Kazuki, Mitsuhiko Osaki, Naoyo Kajitani, Yuwna Yakura, Mitsuo Oshimura, Yasuhiro Kazuki · 2018 · Biochemical and Biophysical Research Communications
  23. Down Syndrome Fetal Fibroblasts Display Alterations of Endosomal Trafficking Possibly due to SYNJ1 Overexpression
    Laura De Rosa, D Fasano, Lucrezia Zerillo, Valeria Valente, Antonella Izzo, Nunzia Mollo, Giuseppina Amodio, Elena Polishchuk, Roman Polishchuk, Mariarosa Anna Beatrice Melone et al. · 2022 · Frontiers in Genetics
  24. Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome
    Karol Charkiewicz, Monika Zbucka-Krętowska, Joanna Gościk, Sławomir Wołczyński, Adam Lemancewicz, Piotr Laudański · 2016 · Journal of Immunology Research
  25. Analysis of genotype effects and inter-individual variability in iPSC-derived trisomy 21 neural progenitor cells
    Sarah Emerson Lee, Laura L. Baxter, Monica I Duran, Samuel D Morris, Iman A Mosley, K. Fuentes, Jeroen L. A. Pennings, Fayçal Guedj, Diana W. Bianchi · 2024 · Human Molecular Genetics
  26. The Study of Alternative Splicing Events in Human Induced Pluripotent Stem Cells From a Down's Syndrome Patient
    Yunjie Wang, Zexu Li, Guanheng Yang, Linlin Cai, Fan Yang, Yaqiong Zhang, Yi‐Tao Zeng, Qingwen Ma, Fanyi Zeng · 2021 · Frontiers in Cell and Developmental Biology
  27. Parallel derivation of X-monosomy induced pluripotent stem cells (iPSCs) with isogenic control iPSCs
    Anis Féki, Frederique Sloan Bena, Youssef Hibaoui · 2020 · Stem Cell Research
  28. Cerebral organoid proteomics reveals signatures of dysregulated cortical development associated with human trisomy 21
    Tristan D. McClure‐Begley, Christopher C. Ebmeier, Kerri A. Ball, Jeremy R. Jacobsen, Igor Kogut, Ganna Bilousova, Michael W. Klymkowsky, William M. Old · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  29. The Hallmarks of Aneuploidy in Cancer and Congenital Syndromes
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  30. Can Green Tea Polyphenols Improve Phenotypes Associated With Down Syndrome?
    Randall J. Roper, Charles R. Goodlett · 2018 · Elsevier eBooks
  31. Advancing Knowledge of Down Syndrome Brain Development and Function With Human Stem Cells
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  33. Systematic Tracking of Disrupted Modules Identifies Altered Pathways Associated with Congenital Heart Defects in Down Syndrome
    Denghong Chen, Zhenhua Zhang, Yu-Xiu Meng · 2015 · Medical Science Monitor
  34. Neurodevelopmental Abnormalities in Down Syndrome: Assessing Structural and Functional Deficits
    Joelle Robinson, Nidhi Chawla, Shreya Patel, Eliana Spey, Olivia McNulty, Gurjinder Kaur · 2024 · Cureus
  35. Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cells
    Akiko Tanuma‐Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Ryo Takagi, Ayumi Yamaguchi, Osamu Samura, Hidenori Akutsu, Haruhiko Sago, Tohru Kiyono, Aikou Okamoto et al. · 2021 · Stem Cell Research & Therapy
  36. DYRK1A and Parkinson’s disease, facts and hypotheses
    Laurent Meijer, Mattias F. Lindberg, Gaëlle Hogrel, Bernard Khor · 2026 · Neurobiology of Disease
  37. Cognitive impairments in adult mice with RIP140 overexpression in neural stem cells.
    Xin-Juan Wang, Shimeng Ren, Wei-Dong Yu, Qing Mu, Shuai Ye, C. Cui, Jing-Zhu Guo · 2020 · Behavioural Brain Research
  38. Children With Trisomy 21 and Lennox-Gastaut Syndrome With Predominant Myoclonic Seizures
    Matthew MacDonald, Jacqueline Crawford, Anita Datta · 2021 · Journal of Child Neurology
  39. Neural tissue microphysiological systems in the era of patient-derived pluripotent stem cells
    Alison E. Mungenast, Rebecca Aron, James David White, Daniel F. Tardiff, Waseem Khan Raja · 2018 · Elsevier eBooks
  40. Neural Cell Fate Determination
    Steven Moore, Frederick J. Livesey · 2014 · Elsevier eBooks
  41. Utility of Human Stem Cells for Drug Discovery
    Satyan Chintawar, Martin R. Graf, M. Zameel Cader · 2014 · Royal Society of Chemistry eBooks
  42. Cell Fate Engineering Tools for iPSC Disease Modeling
    Emily K.W. Lo, Patrick Cahan · 2019 · Methods in molecular biology
  43. Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation
    Eric C Swanson · 2014 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
  44. In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
    Vishi Sharma, Harish Chhawari, Pournima Joshi, Sunita Nehra, Nishant Singhal · 2025 · Journal of Visualized Experiments
  45. Indukált pluripotens őssejtek szerepe a neurológiai betegségek modellezésében
    Zoltán Balogh, János Réthelyi, Mária Judit Molnár · 2015 · Orvosi Hetilap
  46. Síndrome de Down como fator de risco genético para a Doença de Alzheimer
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  47. Transcriptome Analysis as a Tool for Investigation of Pathogenesis of Chromosomal Diseases
    М. Е. Лопаткина, И. Н. Лебедев · 2020 · Russian Journal of Genetics
  48. Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndrome
    Manasi Agrawal, Nikita Kirkise, Katelyn Rygel, Pabitra K Sahoo, Carly J Vincent, Daniel Joyner, Ricardo Aguilar-Alvarez, Trey R Philip, Parker S. Dhillon, Juhi Patel et al. · 2025 · bioRxiv
  49. miR155 triplicated in Down syndrome regulates hippocampal GABAergic neurogenesis in Alzheimer’s disease
    Xiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aisha Al-subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Generation and Characterisation of Induced Pluripotent Stem Cells Derived from Human Hair Follicle Keratinocytes
    Sheng Jye Lim · 2015
  51. Cell Reprogramming for Cardiac Regeneration and Rare Disease Modeling
    Xonia Carvajal‐Vergara, Juan R. Rodríguez-Madoz, Beatriz Pelacho, Felipe Prósper · 2017 · Molecular and translational medicine
  52. Precision Genome Editing in Human-Induced Pluripotent Stem Cells
    Knut Woltjen · 2019 · Current human cell research and applications
  53. Caracterização de um novo RNA longo não codificador e seu provável papel no desenvolvimento neuronal
    Isabela Ichihara de Barros · 2021 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  54. Gene-dosage imbalance and altered neurogenesis in Down syndrome
    Bani Bandana Ganguly · 2022 · Elsevier eBooks
  55. Imbalance in glutamatergic and GABAergic transmission in Down syndrome and therapeutic targets
    Bani Bandana Ganguly · 2022 · Elsevier eBooks
  56. The Struggle of Neural Progenitors in Down Syndrome Brain: The Need for Neuromodulation Beyond Symptomatic Mitigations
    King‐Hwa Ling, Pike-See Cheah · 2022 · Malaysian Journal of Medicine and Health Sciences
  57. Realizing the potential of exploiting human IPSCs and their derivatives in research of Down syndrome
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  58. Human Models of Down Syndrome
    Megan Jandy, Hao Hu, Yan Liu, Anita Bhattacharyya · 2025 · Springer eBooks
  59. Unraveling the Genetic and Phenotypic Complexity of Down Syndrome from Trisomy 21 to Comorbid Conditions
    Rajasekhar Moka, Manjima Sudheer, Prabodh Kumar · 2025 · International Journal of Genetics and Genomics
  60. Down Syndrome: Progress in Defining Pathogenesis and Treatments for Neurodevelopmental Deficits and Alzheimer’s Disease
    Renata Bartesaghi, Xu‐Qiao Chen, Aaron D. Johnstone, Utpal Das, William Cary Mobley · 2025 · Springer eBooks
  61. Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome
    Koki Harada, Keiichi Ishihara, Sayaka Wakayama, Teruhiko Wakayama, Sae Yamamoto, Haruhiko Sago, Shun Shimohama, Satoshi Akiba, Florent Ginhoux, Kazuyuki Takata · 2025 · Immunology
  62. Additional file 3 of Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cells
    Akiko Tanuma‐Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Takagi, Ryo, Yamaguchi, Ayumi, Osamu Samura, Akutsu, Hidenori, Haruhiko Sago, Tohru Kiyono, Okamoto, Aikou et al. · 2021 · Figshare
  63. Additional file 4 of Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cells
    Akiko Tanuma‐Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Takagi, Ryo, Yamaguchi, Ayumi, Osamu Samura, Hidenori Akutsu, Haruhiko Sago, Tohru Kiyono, Okamoto, Aikou et al. · 2021 · Figshare
  64. Additional file 5 of Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cells
    Akiko Tanuma‐Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Takagi, Ryo, Yamaguchi, Ayumi, Osamu Samura, Hidenori Akutsu, Haruhiko Sago, Tohru Kiyono, Okamoto, Aikou et al. · 2021 · Figshare
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    Fabio Marchianò · 2022 · theses.fr (ABES)
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    Jenny A. Klein, Suraj Upadhya, Anna J. Nathanson, Dana Silvian, Eric F. Zaniewski, Robert Morris, Wilhelm Haas, Lindy E. Barrett · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  69. miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models
    Xiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al‐subaie, Valentina Fossati, Scott Noggle, Sam Gandy et al. · 2026 · Alzheimer s & Dementia
  70. DHA-H and HPA restore impaired neurogenic phenotypes and BDNF-TrkB signaling in Ts65Dn neurospheres and hippocampus
    Enrico Castroflorio, Joan Cabot, Margalida Suau, Ain Justin Santillan, Guillermo Vicens Gomez, Paula Fernández‐García, Victoria Lladó, Pablo V. Escribá, M. Torres · 2026 · Biomedicine & Pharmacotherapy