Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21
Hibaoui, Youssef, Grad, Iwona, Letourneau, Audrey, Sailani, M Reza, Dahoun, Sophie, Santoni, Federico A, Gimelli, Stefania, Guipponi, Michel, Pelte, Marie Françoise, Béna, Frédérique, Antonarakis, Stylianos E, Feki, Anis·2014·EMBO Molecular Medicine
Cited by (170)
Items 101–170 of 170
- Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brainSean J. Farley, Alla Grishok, Ella Zeldich · 2022 · Epigenetics & Chromatin
- Data in brief: Transcriptome analysis of induced pluripotent stem cells from monozygotic twins discordant for trisomy 21Youssef Hibaoui, Iwona Grad, Audrey Letourneau, Federico Andrea Santoni, Stylianos E. Antonarakis, Anis Féki · 2014 · Genomics Data
- Alzheimer’s disease like neuropathology in Down syndrome cortical organoidsHelen Zhao, Gabriel George Haddad · 2022 · Frontiers in Cellular Neuroscience
- Concise Review: Methods and Cell Types Used to Generate Down Syndrome Induced Pluripotent Stem CellsYoussef Hibaoui, Anis Féki · 2015 · Journal of Clinical Medicine
- Investigating pediatric disorders with induced pluripotent stem cellsMatthew D. Durbin, Adrian Gabriel Cadar, Young Wook Chun, Charles C. Hong · 2018 · Pediatric Research
- Modeling Klinefelter Syndrome Using Induced Pluripotent Stem Cells Reveals Impaired Germ Cell DifferentiationOlivier Botman, Youssef Hibaoui, Maria Grazia Giudice, Jérôme Ambroise, Catherine Creppe, Anis Féki, Christine Wyns · 2020 · Frontiers in Cell and Developmental Biology
- Abnormalities of DYRK1A-Cytoskeleton Complexes in the Blood Cells as Potential Biomarkers of Alzheimer’s DiseaseKarol Dowjat, Tatyana Adayev, Urszula Wojda, Katarzyna Brzozowska, Anna K. Barczak, Tomasz Gabryelewicz, Yu‐Wen Hwang · 2019 · Journal of Alzheimer s Disease
- Drug-Targeted Genomes: Mutability of Ion Channels and GPCRsRegan Raines, Ian McKnight, Hunter White, Kaitlyn Legg, Chan Lee, Wei Li, Peter H.U. Lee, Joon Wan Shim · 2022 · Biomedicines
- One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosageBeatrice Vione, Giuseppe Ramacieri, Giacomo Zavaroni, Angela Piano, Giorgia La Rocca, Maria Caracausi, Lorenza Vitale, Allison Piovesan, Caterina Gori, Gian Luca Pirazzoli et al. · 2022 · Frontiers in Medicine
- Single‐cell landscape analysis reveals systematic senescence in mammalian Down syndromeYao Chen, Yanyu Xiao, Yanye Zhang, Renying Wang, Feixia Wang, Huajing Gao, Yifeng Liu, Runju Zhang, Huiyu Sun, Ziming Zhou et al. · 2023 · Clinical and Translational Medicine
- Exploratory analysis of the proteomic profile in plasma in adults with Down syndrome in the context of Alzheimer's diseaseOlivia Wagemann, Georg Nübling, Francisco J. Martínez-Murcia, Elisabeth Wlasich, Sandra Virginia Loosli, Katja Sandkühler, Anna Stockbauer, Catharina Prix, Sabrina Katzdobler, Agnese Petrera et al. · 2025 · Alzheimer s & Dementia
- Altered development of dopaminergic neurons differentiated from stem cells from human exfoliated deciduous teeth of a patient with Down syndromeThanh Thi Mai Pham, Hiroki Kato, Haruyoshi Yamaza, Keiji Masuda, Yuta Hirofuji, Hiroshi Sato, Huong Thi Nguyen Nguyen, Xu Han, Yu Xin Zhang, Tomoaki Taguchi et al. · 2018 · BMC Neurology
- Neuronal Cell-Intrinsic Defects in Mouse Models of Down SyndromeChiotto, Alessandra Maria Adelaide, Migliorero, Martina, Pallavicini, Gianmarco, Bianchi, Federico Tommaso, Gai, Marta, Di Cunto, Ferdinando, Berto, Gaia Elena · 2019 · Frontiers in Neuroscience
- Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem CellsYohei Hayashi, Miho Takami, Mami Matsuo‐Takasaki · 2020 · Frontiers in Cellular Neuroscience
- Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down SyndromeIshihara, Keiichi · 2021 · Genes
- Influence of Microenvironmental Orchestration on Multicellular Lung Alveolar Organoid Development from Human Induced Pluripotent Stem CellsVedat Burak Ozan, Huijuan Wang, Akshay Akshay, Deepika Anand, Youssef Hibaoui, Anis Féki, Janine Gote-Schniering, Ali Hashemi Gheinani, Manfred Heller, Anne‐Christine Uldry et al. · 2024 · Stem Cell Reviews and Reports
- Astrocytic Alterations and Dysfunction in Down Syndrome: Focus on Neurogenesis, Synaptogenesis, and Neural Circuits FormationBeatrice Uguagliati, Mariagrazia Grilli · 2024 · Cells
- Conducting Clinical Trials in Twin Populations: A Review of Design, Analysis, Recruitment and Ethical Issues for Twin-Only TrialsLisa Nicole Yelland, Katrina J. Scurrah, Paulo H. Ferreira, Lucas Calais‐Ferreira, Monica Rankin, Jane Denton, Merryl Harvey, Katherine J. Lee, Evie Shoshannah Kendal, Jeffrey Mark Craig · 2021 · Twin Research and Human Genetics
- Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down SyndromeCampbell, Natalie Baker, Patel, Yesha, Moore, Tara L., Medalla, Maria, Zeldich, Ella · 2023 · International Journal of Molecular Sciences
- Generation of improved human cerebral organoids from single copy DYRK1A knockout induced pluripotent stem cells in trisomy 21: hypothetical solutions for neurodevelopmental models and therapeutic alternatives in down syndromeElif Çağlayan · 2016 · Cell Biology International
- Measurement of synaptic density in Down syndrome using PET imaging: a pilot studyAlexandra H DiFilippo, Erin McMullen Jonaitis, Renee Makuch, Brianna Piro‐Gambetti, Victoria Fleming, Gilda E. Ennis, Todd E. Barnhart, Jonathan W. Engle, Barbara B. Bendlin, Sterling C. Johnson et al. · 2024 · Scientific Reports
- Generation of a novel isogenic trisomy panel in human embryonic stem cells via microcell-mediated chromosome transferKei Hiramatsu, Satoshi Abe, Kanako Kazuki, Mitsuhiko Osaki, Naoyo Kajitani, Yuwna Yakura, Mitsuo Oshimura, Yasuhiro Kazuki · 2018 · Biochemical and Biophysical Research Communications
- Down Syndrome Fetal Fibroblasts Display Alterations of Endosomal Trafficking Possibly due to SYNJ1 OverexpressionLaura De Rosa, D Fasano, Lucrezia Zerillo, Valeria Valente, Antonella Izzo, Nunzia Mollo, Giuseppina Amodio, Elena Polishchuk, Roman Polishchuk, Mariarosa Anna Beatrice Melone et al. · 2022 · Frontiers in Genetics
- Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down SyndromeKarol Charkiewicz, Monika Zbucka-Krętowska, Joanna Gościk, Sławomir Wołczyński, Adam Lemancewicz, Piotr Laudański · 2016 · Journal of Immunology Research
- Analysis of genotype effects and inter-individual variability in iPSC-derived trisomy 21 neural progenitor cellsSarah Emerson Lee, Laura L. Baxter, Monica I Duran, Samuel D Morris, Iman A Mosley, K. Fuentes, Jeroen L. A. Pennings, Fayçal Guedj, Diana W. Bianchi · 2024 · Human Molecular Genetics
- The Study of Alternative Splicing Events in Human Induced Pluripotent Stem Cells From a Down's Syndrome PatientYunjie Wang, Zexu Li, Guanheng Yang, Linlin Cai, Fan Yang, Yaqiong Zhang, Yi‐Tao Zeng, Qingwen Ma, Fanyi Zeng · 2021 · Frontiers in Cell and Developmental Biology
- Parallel derivation of X-monosomy induced pluripotent stem cells (iPSCs) with isogenic control iPSCsAnis Féki, Frederique Sloan Bena, Youssef Hibaoui · 2020 · Stem Cell Research
- Cerebral organoid proteomics reveals signatures of dysregulated cortical development associated with human trisomy 21Tristan D. McClure‐Begley, Christopher C. Ebmeier, Kerri A. Ball, Jeremy R. Jacobsen, Igor Kogut, Ganna Bilousova, Michael W. Klymkowsky, William M. Old · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- The Hallmarks of Aneuploidy in Cancer and Congenital SyndromesPan Cheng, Karan Singh, Roger H. Reeves, Teresa Davoli · 2025 · Annual Review of Genomics and Human Genetics
- Can Green Tea Polyphenols Improve Phenotypes Associated With Down Syndrome?Randall J. Roper, Charles R. Goodlett · 2018 · Elsevier eBooks
- Advancing Knowledge of Down Syndrome Brain Development and Function With Human Stem CellsAnita Bhattacharyya · 2020 · American Journal on Intellectual and Developmental Disabilities
- Clinical insights into catechin-based nanomedicine: a review of therapeutic potential in neurodegenerative diseasesMd. Al Amin, Mehrukh Zehravi, Sherouk Hussein Sweilam, Thukani Sathanantham Shanmugarajan, Uppuluri Varuna Naga Venkata Arjun, Mogan Babu Nagaiyan, S. Mounika Reddy, Vijayakumar Subash, Kalam Mary swarnalatha, Arjun Pazhanikumar et al. · 2025 · 3 Biotech
- Systematic Tracking of Disrupted Modules Identifies Altered Pathways Associated with Congenital Heart Defects in Down SyndromeDenghong Chen, Zhenhua Zhang, Yu-Xiu Meng · 2015 · Medical Science Monitor
- Neurodevelopmental Abnormalities in Down Syndrome: Assessing Structural and Functional DeficitsJoelle Robinson, Nidhi Chawla, Shreya Patel, Eliana Spey, Olivia McNulty, Gurjinder Kaur · 2024 · Cureus
- Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cellsAkiko Tanuma‐Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Ryo Takagi, Ayumi Yamaguchi, Osamu Samura, Hidenori Akutsu, Haruhiko Sago, Tohru Kiyono, Aikou Okamoto et al. · 2021 · Stem Cell Research & Therapy
- DYRK1A and Parkinson’s disease, facts and hypothesesLaurent Meijer, Mattias F. Lindberg, Gaëlle Hogrel, Bernard Khor · 2026 · Neurobiology of Disease
- Cognitive impairments in adult mice with RIP140 overexpression in neural stem cells.Xin-Juan Wang, Shimeng Ren, Wei-Dong Yu, Qing Mu, Shuai Ye, C. Cui, Jing-Zhu Guo · 2020 · Behavioural Brain Research
- Children With Trisomy 21 and Lennox-Gastaut Syndrome With Predominant Myoclonic SeizuresMatthew MacDonald, Jacqueline Crawford, Anita Datta · 2021 · Journal of Child Neurology
- Neural tissue microphysiological systems in the era of patient-derived pluripotent stem cellsAlison E. Mungenast, Rebecca Aron, James David White, Daniel F. Tardiff, Waseem Khan Raja · 2018 · Elsevier eBooks
- Neural Cell Fate DeterminationSteven Moore, Frederick J. Livesey · 2014 · Elsevier eBooks
- Utility of Human Stem Cells for Drug DiscoverySatyan Chintawar, Martin R. Graf, M. Zameel Cader · 2014 · Royal Society of Chemistry eBooks
- Cell Fate Engineering Tools for iPSC Disease ModelingEmily K.W. Lo, Patrick Cahan · 2019 · Methods in molecular biology
- Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A DissertationEric C Swanson · 2014 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
- In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem CellsVishi Sharma, Harish Chhawari, Pournima Joshi, Sunita Nehra, Nishant Singhal · 2025 · Journal of Visualized Experiments
- Indukált pluripotens őssejtek szerepe a neurológiai betegségek modellezésébenZoltán Balogh, János Réthelyi, Mária Judit Molnár · 2015 · Orvosi Hetilap
- Síndrome de Down como fator de risco genético para a Doença de AlzheimerThiago José Monteiro Borges da Silva Valente, João Marcos da Silva Dantas, Helder Elísio Evangelista Vieira, Albert Eduardo Silva Martins · 2022 · Anais da Faculdade de Medicina de Olinda
- Transcriptome Analysis as a Tool for Investigation of Pathogenesis of Chromosomal DiseasesМ. Е. Лопаткина, И. Н. Лебедев · 2020 · Russian Journal of Genetics
- Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndromeManasi Agrawal, Nikita Kirkise, Katelyn Rygel, Pabitra K Sahoo, Carly J Vincent, Daniel Joyner, Ricardo Aguilar-Alvarez, Trey R Philip, Parker S. Dhillon, Juhi Patel et al. · 2025 · bioRxiv
- miR155 triplicated in Down syndrome regulates hippocampal GABAergic neurogenesis in Alzheimer’s diseaseXiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aisha Al-subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Generation and Characterisation of Induced Pluripotent Stem Cells Derived from Human Hair Follicle KeratinocytesSheng Jye Lim · 2015
- Cell Reprogramming for Cardiac Regeneration and Rare Disease ModelingXonia Carvajal‐Vergara, Juan R. Rodríguez-Madoz, Beatriz Pelacho, Felipe Prósper · 2017 · Molecular and translational medicine
- Precision Genome Editing in Human-Induced Pluripotent Stem CellsKnut Woltjen · 2019 · Current human cell research and applications
- Caracterização de um novo RNA longo não codificador e seu provável papel no desenvolvimento neuronalIsabela Ichihara de Barros · 2021 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Gene-dosage imbalance and altered neurogenesis in Down syndromeBani Bandana Ganguly · 2022 · Elsevier eBooks
- Imbalance in glutamatergic and GABAergic transmission in Down syndrome and therapeutic targetsBani Bandana Ganguly · 2022 · Elsevier eBooks
- The Struggle of Neural Progenitors in Down Syndrome Brain: The Need for Neuromodulation Beyond Symptomatic MitigationsKing‐Hwa Ling, Pike-See Cheah · 2022 · Malaysian Journal of Medicine and Health Sciences
- Realizing the potential of exploiting human IPSCs and their derivatives in research of Down syndromeY. Wang, Jielei Ni, YUHAN LIU, Ding-Ying Liao, Qianwen Zhou, Xiaoyang Ji, GANG NIU, Yanxiang Ni · 2023 · Biocell
- Human Models of Down SyndromeMegan Jandy, Hao Hu, Yan Liu, Anita Bhattacharyya · 2025 · Springer eBooks
- Unraveling the Genetic and Phenotypic Complexity of Down Syndrome from Trisomy 21 to Comorbid ConditionsRajasekhar Moka, Manjima Sudheer, Prabodh Kumar · 2025 · International Journal of Genetics and Genomics
- Down Syndrome: Progress in Defining Pathogenesis and Treatments for Neurodevelopmental Deficits and Alzheimer’s DiseaseRenata Bartesaghi, Xu‐Qiao Chen, Aaron D. Johnstone, Utpal Das, William Cary Mobley · 2025 · Springer eBooks
- Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down SyndromeKoki Harada, Keiichi Ishihara, Sayaka Wakayama, Teruhiko Wakayama, Sae Yamamoto, Haruhiko Sago, Shun Shimohama, Satoshi Akiba, Florent Ginhoux, Kazuyuki Takata · 2025 · Immunology
- Additional file 3 of Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cellsAkiko Tanuma‐Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Takagi, Ryo, Yamaguchi, Ayumi, Osamu Samura, Akutsu, Hidenori, Haruhiko Sago, Tohru Kiyono, Okamoto, Aikou et al. · 2021 · Figshare
- Additional file 4 of Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cellsAkiko Tanuma‐Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Takagi, Ryo, Yamaguchi, Ayumi, Osamu Samura, Hidenori Akutsu, Haruhiko Sago, Tohru Kiyono, Okamoto, Aikou et al. · 2021 · Figshare
- Additional file 5 of Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cellsAkiko Tanuma‐Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Takagi, Ryo, Yamaguchi, Ayumi, Osamu Samura, Hidenori Akutsu, Haruhiko Sago, Tohru Kiyono, Okamoto, Aikou et al. · 2021 · Figshare
- Optimisation de la différenciation neuronale et musculaire de cellules pluripotentes induites humaines pour la modélisation des maladies rares : exemple du syndrome de DiGeorgeCherif Badja · 2015 · theses.fr (ABES)
- Role of astrocytic signaling in synapse function : implications for neurodevelopmental disordersBruna Rubino · 2020 · theses.fr (ABES)
- Multi-omics data integration and interactive visual data mining to explore mitochondrial dynamicsFabio Marchianò · 2022 · theses.fr (ABES)
- Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21Jenny A. Klein, Suraj Upadhya, Anna J. Nathanson, Dana Silvian, Eric F. Zaniewski, Robert Morris, Wilhelm Haas, Lindy E. Barrett · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC modelsXiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al‐subaie, Valentina Fossati, Scott Noggle, Sam Gandy et al. · 2026 · Alzheimer s & Dementia
- DHA-H and HPA restore impaired neurogenic phenotypes and BDNF-TrkB signaling in Ts65Dn neurospheres and hippocampusEnrico Castroflorio, Joan Cabot, Margalida Suau, Ain Justin Santillan, Guillermo Vicens Gomez, Paula Fernández‐García, Victoria Lladó, Pablo V. Escribá, M. Torres · 2026 · Biomedicine & Pharmacotherapy