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Cited by 33Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchEpilepsy research and treatment

Sleep‐wake characteristics in a mouse model of severe traumatic brain injury: Relation to posttraumatic epilepsy

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Konduru, Sai Sruthi, Wallace, Eli P., Pfammatter, Jesse A., Rodrigues, Paulo V., Jones, Mathew V., Maganti, Rama K.·2021·Epilepsia Open
DOI 10.1002/epi4.12462PMC PMC7918302

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Abstract

Study objectives: Traumatic brain injury (TBI) results in sequelae that include posttraumatic epilepsy (PTE) and sleep‐wake disturbances. Here, we sought to determine whether sleep characteristics could predict development of PTE in a model of severe TBI. Methods: Following controlled cortical impact (CCI) or sham injury (craniotomy only), CD‐1 mice were implanted with epidural electroencephalography (EEG) and nuchal electromyography (EMG) electrodes. Acute (1st week) and chronic (months 1, 2, or 3) 1‐week‐long video‐EEG recordings were performed after the injury to examine epileptiform activity. High‐amplitude interictal events were extracted from EEG using an automated method. After scoring sleep‐wake patterns, sleep spindles and EEG delta power were derived from nonrapid eye movement (NREM) sleep epochs. Brain CTs (computerized tomography) were performed in sham and CCI cohorts to quantify the brain lesions. We then employed a no craniotomy (NC) control to perform 1‐week‐long EEG recordings at week 1 and month 1 after surgery. Results: Posttraumatic seizures were seen in the CCI group only, whereas interictal epileptiform activity was seen in CCI or sham. Sleep‐wake disruptions consisted of shorter wake or NREM bout lengths and shorter duration or lower power for spindles in CCI and sham. NREM EEG delta power increased in CCI and sham groups compared with NC though the CCI group with posttraumatic seizures had lower power at a chronic time point compared with those without. Follow‐up brain CTs showed a small lesion in the sham injury group suggesting a milder form of TBI that may account for their interictal activity and sleep changes. Significance: In our TBI model, tracking changes in NREM delta power distinguishes between CCI acutely and animals that will eventually develop PTE, but further work is necessary to identify sleep biomarkers of PTE. Employing NC controls together with sham controls should be considered in future TBI studies.

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  • Animal models recapitulate sleep phenotypes of disordered sleep in humans, especially excessive daytime sleepiness.

    “Animal models recapitulate sleep phenotypes of disordered sleep in humans, especially that of EDS.22,44,45,48,49,64–73”

    From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [66]

    The Introduction (page not available) describes hypersomnia in people after traumatic brain injury and sleep disruptions in animal TBI models. The Discussion (page not available) reports acute hypersomnia in some rodent studies, but says the animal findings conflict and that this study found no consistent disturbance attributable solely to brain injury. It therefore supports a narrower parallel, not the broad claim that animal models recapitulate human disordered-sleep phenotypes, especially excessive daytime sleepiness. (LLM, conf=0.83)

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Cited by

Sorted by citations

Authors
Konduru, S. S., Wallace, E. P., Pfammatter, J. A., Rodrigues, P. V., Jones, M. V., & Maganti, R. K.
Affiliations
  • Department of Neurology University of Wisconsin School of Medicine and Public Health Madison WI USA
  • University of Wisconsin–Madison (US)
Corresponding author
Maganti, Rama K.
ORCID
Venue
Epilepsia Open
Publisher
Wiley
Published
2021-01-15
Volume
6
Issue
1
Pages
181-194
ISSN
2470-9239 (ISSN-L)
DOI
10.1002/epi4.12462
PMC
PMC7918302
OpenAlex
W3115193185
Cited by
33
References
5
Citations by year
2026: 9 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 1
FWCI
1.41
Type
journal article
Language
en
Open access
Licence
Locations
  • Epilepsia Open (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institute of Neurological Disorders and Stroke (R21NS104612‐01A1)
  • U.S. Department of Defense (PRMRP:161864)
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Keywords
traumatic brain injury, post-traumatic epilepsy, sleep-wake patterns, sleep spindles, interictal epileptiform activity, controlled cortical impact, sleep biomarkers, seizure prediction, brain lesions, mouse model
MeSH terms
Brain Injuries, Traumatic, Animals, Brain, Disease Models, Animal, Electroencephalography, Electromyography, Epilepsy, Post-Traumatic, Male, Sleep Wake Disorders, Tomography, X-Ray Computed, Video Recording, Mice

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