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Biotic ligand model of the acute toxicity of metals. 2. Application to acute copper toxicity in freshwater fish and Daphnia
Abstract
The biotic ligand model (BLM) was developed to explain and predict the effects of water chemistry on the acute toxicity of metals to aquatic organisms. The biotic ligand is defined as a specific receptor within an organism where metal complexation leads to acute toxicity. The BLM is designed to predict metal interactions at the biotic ligand within the context of aqueous metal speciation and competitive binding of protective cations such as calcium. Toxicity is defined as accumulation of metal at the biotic ligand at or above a critical threshold concentration. This modeling framework provides mechanistic explanations for the observed effects of aqueous ligands, such as natural organic matter, and water hardness on metal toxicity. In this paper, the development of a copper version of the BLM is described. The calibrated model is then used to calculate LC50 (the lethal concentration for 50% of test organisms) and is evaluated by comparison with published toxicity data sets for freshwater fish (fathead minnow, Pimephales promelas) and Daphnia.
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Citations
Cited by
Grosell, M., Nielsen, C., & Bianchini, A. (2002) · Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00085-6 · Cited by 347
Water quality improvement through reductions of pollutant loads using bioretention
Li, H., & Davis, A. P. (2009) · Journal of Environmental Engineering · doi:10.1061/(asce)ee.1943-7870.0000026 · Cited by 238
Wilde, K. L., Stauber, J. L., Markich, S. J., Franklin, N. M., & Brown, P. L. (2006) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-004-0256-0 · Cited by 192
Codling, G., Yuan, H., Jones, P. D., Giesy, J. P., & Hecker, M. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-08070-2 · Cited by 67
Metadata
- Authors
- Santore, R. C., Di Toro, D. M., Paquin, P. R., Allen, H. E., & Meyer, J. S.
- Venue
- Environmental Toxicology and Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-10-01
- Volume
- 20
- Issue
- 10
- Pages
- 2397-2402
- ISSN
- 0730-7268 (ISSN-L)
- 1552-8618
- OpenAlex
- W2104273489
- Cited by
- 539
- References
- 0
- FWCI
- 17.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Santore, R. C., Di Toro, D. M., Paquin, P. R., Allen, H. E., & Meyer, J. S. (2001). Biotic ligand model of the acute toxicity of metals. 2. Application to acute copper toxicity in freshwater fish and Daphnia. Environmental Toxicology and Chemistry. https://doi.org/10.1002/etc.5620201035
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