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Cited by 20COVID-19 Clinical Research StudiesVitamin C and Antioxidants ResearchVitamin D Research Studies

Antioxidants and clinical outcomes of patients with coronavirus disease 2019: A systematic review of observational and interventional studies

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Foshati, Sahar, Mirjalili, Fatemeh, Rezazadegan, Mahsa, Fakoorziba, Farnoosh, Amani, Reza·2022·Food Science & Nutrition
DOI 10.1002/fsn3.3034PMC PMC9538172
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Abstract

Coronavirus disease 2019 (COVID‐19) is a newly emerging viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Oxidative stress appears to be a prominent contributor to the pathogenicity of SARS‐CoV‐2. Therefore, we carried out a systematic review of human observational and interventional studies to investigate the role of some antioxidants such as vitamins A, E, D, and C, selenium, zinc, and α‐lipoic acid in the main clinical outcomes of subjects with COVID‐19. Google Scholar, Cochrane Library, Web of Science, Scopus, and Medline were searched using Medical Subject Headings (MeSH) and non‐MeSH terms without restrictions. Finally, 36 studies for vitamins C and D, selenium, and zinc were included in this systematic review; however, no eligible studies were found for vitamins A and E as well as α‐lipoic acid. The results showed the promising role of vitamin C in inflammation, Horowitz index, and mortality; vitamin D in disease manifestations and severity, inflammatory markers, lung involvement, ventilation requirement, hospitalization, intensive care unit (ICU) admission, and mortality; selenium in cure rate and mortality; and zinc in ventilation requirement, hospitalization, ICU admission, biomarkers of inflammation and bacterial infection, and disease complications. In conclusion, it seems that antioxidants, especially vitamins C and D, selenium, and zinc, can improve multiple COVID‐19 clinical outcomes. Nevertheless, more studies are necessary to affirm these results.

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  • During the trial, two patients in the control group and one patient in the intervention group dropped out due to COVID-19 infection.

    “During the trial, two patients in the control group and one patient in the intervention group dropped out due to COVID-19 infection, a systemic disease with GI symptoms [27].”

    From The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis: a double-blind randomized placebo-controlled trial (2023) · cites this paper as [27]

    The Methods (Research question) and Results (Study characteristics and quality) describe studies of patients with COVID-19, but do not report the claimed trial dropouts. Searches for the two-control, one-intervention dropout count and withdrawals due to COVID-19 found no matching passage in our copy. In the citing sentence, [27] also appears immediately after the separate description of COVID-19, rather than directly after the dropout count. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Foshati, S., Mirjalili, F., Rezazadegan, M., Fakoorziba, F., & Amani, R.
Affiliations
  • Isfahan University of Medical Sciences (IR)
  • Marquise Hospitality, Compass Group Mississauga Ontario Canada
Corresponding author
Amani, Reza
ORCID
Venue
Food Science & Nutrition
Publisher
Wiley
Published
2022-09-02
Volume
10
Issue
12
Pages
4112-4125
ISSN
2048-7177 (ISSN-L)
DOI
10.1002/fsn3.3034
PMC
PMC9538172
OpenAlex
W4294243064
Cited by
20
References
2
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 1
FWCI
0.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Food Science & Nutrition (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Isfahan University of Medical Sciences (299234)
Topics
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
Keywords
COVID-19 pandemic, SARS-CoV-2, antioxidants, oxidative stress, vitamin C, vitamin D, selenium, zinc, clinical outcomes, mortality, inflammation, disease severity, intensive care unit admission, pulmonary involvement

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