Cited by 1,661Antioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesFree Radicals and Antioxidants

A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives

Open access
Carocho, Márcio, Ferreira, Isabel C.F.R.·2013·Food and Chemical Toxicology

Abstract

Many studies have been conducted with regard to free radicals, oxidative stress and antioxidant activity of food, giving antioxidants a prominent beneficial role, but, recently many authors have questioned their importance, whilst trying to understand the mechanisms behind oxidative stress. Many scientists defend that regardless of the quantity of ingested antioxidants, the absorption is very limited, and that in some cases prooxidants are beneficial to human health. The detection of antioxidant activity as well as specific antioxidant compounds can be carried out with a large number of different assays, all of them with advantages and disadvantages. The controversy around antioxidant in vivo benefits has become intense in the past few decades and the present review tries to shed some light on research on antioxidants (natural and synthetic) and prooxidants, showing the potential benefits and adverse effects of these opposing events, as well as their mechanisms of action and detection methodologies. It also identifies the limitations of antioxidants and provides a perspective on the likely future trends in this field.

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Registry

Crossref · 10.1016/j.fct.2012.09.021

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93 of 93 references verified0 citation errors · 0 not checkable

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Authors
Carocho, M., & Ferreira, I. C. F. R.
Affiliations
Universidade Politécnica de Bragança (PT)
Corresponding author
Ferreira, Isabel C.F.R.
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2013-01
Volume
51
Pages
15-25
ISSN
0278-6915 (ISSN-L)
OpenAlex
W2020621217
Cited by
1,661
References
93
Citations by year
2026: 55 · 2025: 82 · 2024: 108 · 2023: 133 · 2022: 148 · 2021: 149 · 2020: 162 · 2019: 165 · 2018: 142 · 2017: 157 · 2016: 116 · 2015: 121 · 2014: 86 · 2013: 33 · 2012: 4
FWCI
8.21
Type
journal article
Language
en
Open access
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Funders
Fundação para a Ciência e a Tecnologia
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords
antioxidants, pro-oxidants, oxidative stress, free radicals, antioxidant activity assay, natural antioxidants, synthetic antioxidants, dietary antioxidants, mechanism of action
MeSH terms
Antioxidants, Drug Evaluation, Preclinical, Enzymes, Food, Free Radicals, Humans, Reactive Oxygen Species, Oxidative Stress

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