The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile
Abstract
Acute myeloid leukemia (AML) with a complex aberrant karyotype is a distinct biological entity. It is characterized by: (1) a sharp increase in incidence above age 50; (2) a characteristic pattern of chromosomal gain and, especially, loss, that is, of 5q14q33, 7q32q35, and 17p13, translating into reduced expression of genes in these regions; (3) a unique gene expression pattern including up‐regulation of genes involved in DNA repair; (4) a high incidence of TP53 deletions and/or mutations; and (5) an overall unfavorable prognosis. Further unraveling the biology of AML with a complex aberrant karyotype by gene expression profiling may provide deeper insights into the pathogenesis of as well as the reasons for chemoresistance in this AML subtype. These data may be the basis for developing targeted therapeutic strategies to increase the cure rate in patients with AML and a complex aberrant karyotype. © 2005 Wiley‐Liss, Inc.
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Citations
Cites
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168 · cited 4×
“yotypes usually show microsatellite instability, whereas complex aberrant cases do not (Lengauer et al., 1998).”
BackgroundInfluential
Cited by
Haferlach, C., Dicker, F., Schnittger, S., Kern, W., & Haferlach, T. (2007) · Leukemia · doi:10.1038/sj.leu.2404935 · Cited by 351
Self-citationPollyea, D. A., Pratz, K. W., Wei, A. H., Pullarkat, V., Jonas, B. A., Recher, C., Babu, S., Schuh, A. C., Dail, M., Sun, Y., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-1183 · Cited by 159
Steidl, U., Steidl, C., Ebralidze, A., Chapuy, B., Han, H.-J., Will, B., Rosenbauer, F., Becker, A., Wagner, K., Koschmieder, S., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30525 · Cited by 114
Current status and new treatment approaches in TP53 mutated AML
Hunter, A. M., & Sallman, D. A. (2019) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2019.05.004 · Cited by 102
Ali, D., Mohammad, D. K., Mujahed, H., Jonson‐Videsäter, K., Nore, B., Paul, C., & Lehmann, S. (2016) · British Journal of Haematology · doi:10.1111/bjh.14036 · Cited by 49
Metadata
- Authors
- Schoch, C., Kern, W., Kohlmann, A., Hiddemann, W., Schnittger, S., & Haferlach, T.
- Venue
- Genes, Chromosomes and Cancer
- Publisher
- Wiley
- Published
- 2005-04-21
- Volume
- 43
- Issue
- 3
- Pages
- 227-238
- ISSN
- 1045-2257 (ISSN-L)
- 1098-2264
- OpenAlex
- W1981570437
- Cited by
- 188
- References
- 1
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schoch, C., Kern, W., Kohlmann, A., Hiddemann, W., Schnittger, S., & Haferlach, T. (2005). Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile. Genes, Chromosomes and Cancer. https://doi.org/10.1002/gcc.20193
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