Cited by 103Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processesCancer-related Molecular Pathways

Current status and new treatment approaches in TP53 mutated AML

Hunter, Anthony M., Sallman, David A.·2019·Best Practice & Research Clinical Haematology

Abstract

Mutations in the essential tumor suppressor gene, TP53, are observed in only 5-10% of acute myeloid leukemia (AML) cases, but are highly associated with therapy-related AML and cases with complex karyotype. The mutational status of TP53 is a critical prognostic indicator, with dismal outcomes consistently observed across studies. Response rates to traditional cytotoxic chemotherapy are poor and long-term survival after allogeneic hematopoietic stem cell transplant is rare. Therapy with hypomethylating agents has resulted in a modest improvement in outcomes over intensive chemotherapy, but durable responses are seldom observed. In view of the intrinsic resistance to standard chemotherapies conferred by mutations in TP53, novel treatment approaches are required. In this review, we examine the current treatment landscape in TP53 mutated AML and discuss emerging therapeutic approaches currently under clinical investigation.

Integrity signals

Registry

Crossref · 10.1016/j.beha.2019.05.004

Cites

129 of 129 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • TP53 gene mutations are detected in approximately 10%-20% of patients with de novo MDS or AML and 30%-40% of patients with therapy-related disease.

    “TP53 gene mutations are detected in approximately 10%-20% of patients with de novo myelodysplastic syndromes (MDS)1-4 or acute myeloid leukemia (AML)5,6 and 30%-40% of patients with therapy-related disease.7”

Cites

Flagged first, then by citations

3 of the 132 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Hunter, A. M., & Sallman, D. A.
Affiliations
  • University of South Florida (US)
  • Moffitt Cancer Center (US)
Corresponding author
Sallman, David A.
Venue
Best Practice & Research Clinical Haematology
Publisher
Elsevier BV
Published
2019-06
Volume
32
Issue
2
Pages
134-144
ISSN
1521-6926 (ISSN-L)
OpenAlex
W2944248311
Cited by
102
References
132
Citations by year
2026: 5 · 2025: 8 · 2024: 11 · 2023: 20 · 2022: 19 · 2021: 26 · 2020: 10 · 2019: 2
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Locations
  • Best Practice & Research Clinical Haematology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Celgene
  • Jazz
Topics
  • Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
TP53 mutation, acute myeloid leukemia, therapy-related AML, complex karyotype, prognostic factors, chemoresistance, hypomethylating agents, allogeneic hematopoietic stem cell transplantation, novel therapeutic approaches, targeted therapy
MeSH terms
Humans, Mutation, Time Factors, Leukemia, Myeloid, Acute, Survival Rate, Tumor Suppressor Protein p53, Disease-Free Survival

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review