Cited by 30Lymphoma Diagnosis and TreatmentViral-associated cancers and disordersChronic Lymphocytic Leukemia Research

BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B

Bosga‐Bouwer, Anneke G., Haralambieva, Eugenia, Booman, Marije, Boonstra, Ronald, van den Berg, Anke, Schuuring, Ed, van den Berg, Eva, Kluin, Philip +1 more·2005·Genes, Chromosomes and Cancer

Abstract

Translocations involving band 3q27, affecting the major breakpoint region (MBR) of BCL6, are common in diffuse large B‐cell lymphomas (DLBCLs). Recent data suggest an alternative breakpoint cluster region (ABR) located between 245 and 285 kb 5′ of BCL6, which might be associated with Follicular Lymphoma (FL). Ten DLBCLs and 9 FLs grade 3B with cytogenetic rearrangements at 3q27 were studied by fluorescence in situ hybridization (FISH) to discriminate between breakpoints at the ABR and MBR. Eight DLBCLs contained a breakpoint in the MBR, and 6 FL grade 3B (FL3B) cases contained a breakpoint in the ABR. No specific chromosomal partners could be identified in both groups. Previously published data have suggested that FL3B cases with 3q27 aberrations are closely related to the majority of DLBCLs of germinal center cell origin. However, our findings suggest that the mechanism of 3q27 rearrangement in FL3B cases is similar to the mechanism in follicular lymphomas grade 1,2, and 3A cases. © 2005 Wiley‐Liss, Inc.

Integrity signals

Registry

Crossref · 10.1002/gcc.20246

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • BCL6 is a promising drug target for non-Hodgkin lymphomas including diffuse large B cell lymphoma and follicular lymphoma.

    “BCL6 is a promising drug target for non-Hodgkin lymphomas including diffuse large B cell lymphoma (DLBCL)13,14 and follicular lymphoma15.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Bosga‐Bouwer, A. G., Haralambieva, E., Booman, M., Boonstra, R., van den Berg, A., Schuuring, E., van den Berg, E., Kluin, P., & Poppema, S.
Affiliations
University Medical Center Groningen (NL)
Venue
Genes, Chromosomes and Cancer
Publisher
Wiley
Published
2005-08
Volume
44
Issue
3
Pages
301-304
ISSN
  • 1045-2257 (ISSN-L)
  • 1098-2264
OpenAlex
W2144851785
Cited by
30
References
18
Citations by year
2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 1
FWCI
2.21
Type
journal article
Language
en
Open access
closed
Locations
  • Genes Chromosomes and Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
  • Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
Keywords
BCL6, major breakpoint region, diffuse large B-cell lymphoma, chromosomal translocation breakpoints
MeSH terms
Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 3, Humans, Lymphoma, Follicular, Translocation, Genetic, Lymphoma, Large B-Cell, Diffuse, In Situ Hybridization, Fluorescence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review