The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Amplification of cellular oncogenes: A predictor of clinical outcome in human cancer
Abstract
Increased dosage of cellular oncogenes resulting from amplification of DNA is a frequent genetic abnormality of tumor cells and the study of oncogene amplification has been paradigmatic for the usefulness of molecular genetic research in clinical oncology. Certain types of human tumors carry an amplified cellular oncogene at frequencies of up to 50–60%. Human neuroblastoma has been prototypic for the importance of oncogene amplification in tumorigenesis, and evidence is emerging that amplification may be an early event involved in a more malignant form of this cancer. It is unclear at which stage amplification plays a role in other cancers. Amplification of cellular oncogenes is a good predictor of clinical outcome in some human malignancies.
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Citations
Cites
Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471
Alitalo, K., Schwab, M., Lin, C. C., Varmus, H. E., & Bishop, J. M. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.6.1707 · Cited by 761
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Cited by
Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors
Kallioniemi, A., Kallioniemi, O.-P., Sudar, D., Rutovitz, D., Gray, J. W., Waldman, F., & Pinkel, D. (1992) · Science · doi:10.1126/science.1359641 · Cited by 3,297
Molecular themes in oncogenesis
Bishop, J. M. (1991) · Cell · doi:10.1016/0092-8674(91)90636-d · Cited by 1,637
Kallioniemi, O., Kallioniemi, A., Piper, J., Isola, J., Waldman, F. M., Gray, J. W., & Pinkel, D. (1994) · Genes, Chromosomes and Cancer · doi:10.1002/gcc.2870100403 · Cited by 1,012
Fakharzadeh, S. S., Trusko, S. P., & George, D. L. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07676.x · Cited by 704
ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization
Kallioniemi, O. P., Kallioniemi, A., Kurisu, W., Thor, A., Chen, L. C., Smith, H. S., Waldman, F. M., Pinkel, D., & Gray, J. W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5321 · Cited by 555
Metadata
- Authors
- Schwab, M., & Amler, L. C.
- Venue
- Genes, Chromosomes and Cancer
- Publisher
- Wiley
- Published
- 1990-01
- Volume
- 1
- Issue
- 3
- Pages
- 181-193
- ISSN
- 1045-2257 (ISSN-L)
- 1098-2264
- OpenAlex
- W1990582989
- Cited by
- 200
- References
- 2
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schwab, M., & Amler, L. C. (1990). Amplification of cellular oncogenes: A predictor of clinical outcome in human cancer. Genes, Chromosomes and Cancer. https://doi.org/10.1002/gcc.2870010302
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
