The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
TP53 tumor suppressor gene: A model for investigating human mutagenesis
Abstract
More than 350 independent point mutations of the TP53 gene, found in a wide variety of human cancers, were compiled and analysed. From this study, we confirm the presence of four hot‐spot regions which colocalize with some highly conserved domains of the protein. We also define a new hot‐spot region which is observed predominantly in lung tumors. Analysis of the mutational events suggests the direct involvement of environmental carcinogens in lung tumors and hepatocarcinomas, and spontaneous mutagenesis generating essentially CpG transitions in most of the remaining ones. Furthermore, we demonstrate in this work that the TP53 gene is an informative model with which to study the molecular mechanisms of mutagenesis in the human genome.
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Citations
Cites
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
Cited by
The colorectal adenoma–carcinoma sequence
Leslie, A., Carey, F. A., Pratt, N. R., & Steele, R. J. C. (2002) · British Journal of Surgery · doi:10.1046/j.1365-2168.2002.02120.x · Cited by 734
Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.
Harvey, M., McArthur, M. J., Montgomery, C. A., Butel, J. S., Bradley, A., & Donehower, L. A. (1993) · Nature Genetics · doi:10.1038/ng1193-225 · Cited by 542
Cytosine methylation determines hot spots of DNA damage in the human P 53 gene
Denissenko, M. F., Chen, J. X., Tang, M.-S., & Pfeifer, G. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3893 · Cited by 339
Slow Repair of Pyrimidine Dimers at p53 Mutation Hotspots in Skin Cancer
Tornaletti, S., & Pfeifer, G. P. (1994) · Science · doi:10.1126/science.8128225 · Cited by 296
(1994) · PubMed · Cited by 244
Metadata
- Authors
- Fromentel, C. C. D., & Soussi, T.
- Venue
- Genes, Chromosomes and Cancer
- Publisher
- Wiley
- Published
- 1992-01
- Volume
- 4
- Issue
- 1
- Pages
- 1-15
- ISSN
- 1045-2257 (ISSN-L)
- 1098-2264
- OpenAlex
- W2057805027
- Cited by
- 574
- References
- 1
- FWCI
- 38.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fromentel, C. C. D., & Soussi, T. (1992). TP53 tumor suppressor gene: A model for investigating human mutagenesis. Genes, Chromosomes and Cancer. https://doi.org/10.1002/gcc.2870040102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
