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Positional cloning and characterization of mouse mei8, a disrupted allele of the meiotic cohesin Rec8
Abstract
A novel mutation, mei8, was isolated in a forward genetic screen for infertility mutations induced by chemical mutagenesis of ES cells. Homozygous mutant mice are sterile. Mutant females exhibit ovarian dysgenesis and lack ovarian follicles at reproductive maturity. Affected males have small testes due to arrest of spermatogenesis during meiotic prophase I. Genetic mapping and positional cloning of mei8 led to the identification of a mutation in Rec8, a homolog of the yeast meiosis‐specific cohesin gene REC8. Analysis of meiosis in Rec8mei8/Rec8mei8 spermatocytes showed that, while initiation of recombination and synapsis occurs, REC8 is required for the completion and/or maintenance of synapsis, cohesion of sister chromatids, and the formation of chiasmata, as it is in other organisms. However, unlike yeast and Caenorhabditis elegans, localization of REC8 on meiotic chromosomes is not required for the assembly of axial elements. genesis 40:184–194, 2004. © 2004 Wiley‐Liss, Inc.
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Cited by
Absence of Mouse REC8 Cohesin Promotes Synapsis of Sister Chromatids in Meiosis
Xu, H., Beasley, M. D., Warren, W. D., van der Horst, G. T. J., & McKay, M. J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.018 · Cited by 351
Tachibana-Konwalski, K., Godwin, J., van der Weyden, L., Champion, L., Kudo, N. R., Adams, D. J., & Nasmyth, K. (2010) · Genes & Development · doi:10.1101/gad.605910 · Cited by 265
Felipe-Medina, N., Caburet, S., Sánchez-Sáez, F., Condezo, Y. B., de Rooij, D. G., Gómez-H, L., Garcia-Valiente, R., Todeschini, A. L., Duque, P., Sánchez-Martin, M. A., et al. (2020) · eLife · doi:10.7554/elife.56996 · Cited by 45
Metadata
- Authors
- Bannister, L. A., Reinholdt, L. G., Munroe, R. J., & Schimenti, J. C.
- Venue
- genesis
- Publisher
- Wiley
- Published
- 2004-10-27
- Volume
- 40
- Issue
- 3
- Pages
- 184-194
- ISSN
- 1526-954X (ISSN-L)
- 1526-968X
- OpenAlex
- W2023411715
- Cited by
- 188
- References
- 0
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bannister, L. A., Reinholdt, L. G., Munroe, R. J., & Schimenti, J. C. (2004). Positional cloning and characterization of mouse mei8, a disrupted allele of the meiotic cohesin Rec8. genesis. https://doi.org/10.1002/gene.20085
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