The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Family‐based tests for associating haplotypes with general phenotype data: Application to asthma genetics
Abstract
We provide a general purpose family‐based testing strategy for associating disease phenotypes with haplotypes when phase may be ambiguous and parental genotype data may be missing. These tests for linkage and association can be used in candidate gene studies with tightly linked markers. Our proposed weighted conditional approach extends the method described in Rabinowitz and Laird [Human Heredity 504:227–233, 2000] to multiple markers. It is attractive because it provides haplotype tests for family‐based studies that are efficient and robust to population admixture, phenotype distribution specification, and ascertainment based on phenotypes. It can handle missing parental genotypes and/or missing phase in both offspring and parents. It yields either haplotype‐specific (univariate) tests or multi‐haplotype (global) tests. This extension has been implemented in the freely available software haplotype FBAT. We used the haplotype FBAT program to test for associations between asthma phenotypes and single nucleotide polymorphisms (SNPs) in the beta‐2 adrenergic receptor gene. Whereas no single SNP showed significant association with asthma diagnosis or bronchodilator responsiveness (quantitative trait), a haplotype‐based global test found a highly significant association with asthma diagnosis (P value <0.00005) and the measure of bronchodilator responsiveness (P value =0.016). Genet Epidemiol 26:61–69, 2004. © 2003 Wiley‐Liss, Inc.
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Cites
A New Statistical Method for Haplotype Reconstruction from Population Data
Stephens, M., Smith, N. J., & Donnelly, P. (2001) · The American Journal of Human Genetics · doi:10.1086/319501 · Cited by 7,493
Score Tests for Association between Traits and Haplotypes when Linkage Phase Is Ambiguous
Schaid, D. J., Rowland, C. M., Tines, D. E., Jacobson, R. M., & Poland, G. A. (2002) · The American Journal of Human Genetics · doi:10.1086/338688 · Cited by 1,783
Long-Term Effects of Budesonide or Nedocromil in Children with Asthma
(2000) · New England Journal of Medicine · doi:10.1056/nejm200010123431501 · Cited by 1,365
Haplotype tagging for the identification of common disease genes
Johnson, G. C. L., Esposito, L., Barratt, B. J., Smith, A. N., Heward, J., Di Genova, G., Ueda, H., Cordell, H. J., Eaves, I. A., Dudbridge, F., et al. (2001) · Nature Genetics · doi:10.1038/ng1001-233 · Cited by 1,174
A Comparison of Linkage Disequilibrium Measures for Fine-Scale Mapping
DEVLIN, B., & RISCH, N. (1995) · Genomics · doi:10.1006/geno.1995.9003 · Cited by 1,044
Implementing a unified approach to family-based tests of association
Laird, N. M., Horvath, S., & Xu, X. (2000) · Genetic Epidemiology · doi:10.1002/1098-2272(2000)19:1+<::aid-gepi6>3.0.co;2-m · Cited by 856
Self-citationHorvath, S., Xu, X., & Laird, N. M. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200625 · Cited by 739
Self-citationA Generalization of the Transmission/Disequilibrium Test for Uncertain-Haplotype Transmission
Clayton, D. (1999) · The American Journal of Human Genetics · doi:10.1086/302577 · Cited by 635
Rabinowitz, D., & Laird, N. (2000) · Human Heredity · doi:10.1159/000022918 · Cited by 627
Self-citationA Test for Linkage and Association in General Pedigrees: The Pedigree Disequilibrium Test
Martin, E. R., Monks, S. A., Warren, L. L., & Kaplan, N. L. (2000) · The American Journal of Human Genetics · doi:10.1086/302957 · Cited by 538
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Metadata
- Authors
- Horvath, S., Xu, X., Lake, S. L., Silverman, E. K., Weiss, S. T., & Laird, N. M.
- Venue
- Genetic Epidemiology
- Publisher
- Wiley
- Published
- 2003-12-16
- Volume
- 26
- Issue
- 1
- Pages
- 61-69
- ISSN
- 0741-0395 (ISSN-L)
- 1098-2272
- OpenAlex
- W2098611654
- Cited by
- 391
- References
- 24
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- closed
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