Cited by 382Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsPhagocytosis and Immune Regulation

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Microglia and inflammatory mechanisms in the clearance of amyloid β peptide

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Rogers, Joseph, Strohmeyer, Ron, Kovelowski, C.J., Li, Rena·2002·Glia

DOI 10.1002/glia.10153

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Abstract

There is now abundant evidence that brain microglia, when activated, have the lineage, receptors, and synthetic capacity to participate in both potentially neurotoxic inflammatory responses and potentially beneficial phagocytic responses. Amyloid beta peptide (Abeta) forms highly insoluble, beta-pleated aggregates that are widely deposited in the Alzheimer's disease (AD) cortex and limbic system. Aggregated Abeta also activates the classical and alternative complement cascades. These properties make Abeta an excellent target for microglial phagocytosis, a view supported by multiple reports, through well established mechanisms of phagocyte clearance.

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Authors: Rogers, J., Strohmeyer, R., Kovelowski, C. J., & Li, R.
Affiliations: Banner Sun Health Research Institute (US)
Corresponding author: Rogers, Joseph
ORCID: Kovelowski, C.J.
Li, Rena
Venue: Glia
Publisher: Wiley
Published: 2002-10-04
Volume: 40
Issue: 2
Pages: 260-269
ISSN: 0894-1491 (ISSN-L)
1098-1136
DOI: 10.1002/glia.10153
OpenAlex: W2046704592
Cited by: 381
References: 142
Citations by year: 2026: 6 · 2025: 10 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 15 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 12 · 2015: 14 · 2014: 19 · 2013: 17 · 2012: 18
FWCI: 1.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Glia (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Association
National Institute on Aging (AGO7367)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: microglia, amyloid-beta, Alzheimer's disease, microglial phagocytosis, neuroinflammation, complement system, microglial activation
MeSH terms: Alzheimer Disease, Animals, Antigen-Antibody Complex, Antigens, Chemotaxis, Encephalitis, Humans, Phagocytosis, Amyloid beta-Peptides, Microglia

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Microglia and inflammatory mechanisms in the clearance of amyloid β peptide

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