Effect of aging on the microglial response to peripheral nerve injury

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Microglia and neuroinflammation: a pathological perspective

Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works

Cytology & cellular pathology of the nervous system

Penfield, W. G. (1965) · Medical Entomology and Zoology · Cited by 1,035 · see citing works

Functional plasticity of microglia: A review

Streit, W. J., Graeber, M. B., & Kreutzberg, G. W. (1988) · Glia · doi:10.1002/glia.440010502 · Cited by 937 · see citing works

Microglia as neuroprotective, immunocompetent cells of the CNS

Streit, W. J. (2002) · Glia · doi:10.1002/glia.10154 · Cited by 919 · see citing works

Displacement of synaptic terminals from regenerating motoneurons by microglial cells

Blinzinger, K., & Kreutzberg, G. W. (1968) · Cell and Tissue Research · doi:10.1007/bf00325030 · Cited by 855 · see citing works

Dystrophic microglia in the aging human brain

Streit, W. J., Sammons, N. W., Kuhns, A. J., & Sparks, D. L. (2004) · Glia · doi:10.1002/glia.10319 · Cited by 705 · see citing works

Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients

Hukkelhoven, C. W. P. M., Steyerberg, E. W., Rampen, A. J. J., Farace, E., Habbema, J. D. F., Marshall, L. F., Murray, G. D., & Maas, A. I. R. (2003) · Journal of Neurosurgery · doi:10.3171/jns.2003.99.4.0666 · Cited by 641 · see citing works

Lectin binding by resting and reactive microglia

Streit, W. J., & Kreutzberg, G. W. (1987) · Journal of Neurocytology · doi:10.1007/bf01795308 · Cited by 496 · see citing works

Traumatic Brain Injury in the Elderly: Increased Mortality and Worse Functional Outcome At Discharge Despite Lower Injury Severity

Susman, M., DiRusso, S. M., Sullivan, T., Risucci, D. A., Nealon, P., Cuff, S. N., Haider, A. H., & Benzil, D. L. (2002) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-200208000-00004 · Cited by 450 · see citing works

Brain macrophages: evaluation of microglia and their functions

Thomas, W. E. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90007-9 · Cited by 441 · see citing works

Microglia and inflammatory mechanisms in the clearance of amyloid β peptide

Rogers, J., Strohmeyer, R., Kovelowski, C. J., & Li, R. (2002) · Glia · doi:10.1002/glia.10153 · Cited by 381 · see citing works

Altered antigen expression of microglia in the aged rodent CNS

Perry, V. H., Matyszak, M. K., & Fearn, S. (1993) · Glia · doi:10.1002/glia.440070111 · Cited by 364 · see citing works

Microglia and Alzheimer's disease pathogenesis

Streit, W. J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20093 · Cited by 335 · see citing works

Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy

Graeber, M. B., Tetzlaff, W., Streit, W. J., & Kreutzberg, G. W. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90585-x · Cited by 333 · see citing works

The Effect of Age on Functional Outcome in Mild Traumatic Brain Injury: 6-Month Report of a Prospective Multicenter Trial

Mosenthal, A. C., Livingston, D. H., Lavery, R. F., Knudson, M. M., Lee, S., Morabito, D. J., Manley, G. T., Nathens, A. B., Jurkovich, G. J., Hoyt, D. B., et al. (2004) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000127767.83267.33 · Cited by 306 · see citing works

Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study

Vaughan, D. W., & Peters, A. (1974) · Journal of Neurocytology · doi:10.1007/bf01098730 · Cited by 301 · see citing works

Microglia and neuroprotection: implications for Alzheimer's disease

Streit, W. J. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.013 · Cited by 256 · see citing works

Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation

Rozovsky, I., Finch, C. E., & Morgan, T. E. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00169-3 · Cited by 254 · see citing works

Cytology and Cellular Pathology of the Nervous System.

(1932) · Archives of Internal Medicine · doi:10.1001/archinte.1932.00150160159019 · Cited by 250 · see citing works

Microglial Expression of MHC Class II Increases in Normal Aging of Nonhuman Primates

Sheffield, L. G., & Berman, N. E. J. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00168-1 · Cited by 234 · see citing works

Enlarged and phagocytic, but not primed, interleukin-1α-immunoreactive microglia increase with age in normal human brain

Sheng, J. G., Mrak, R. E., & Griffin, W. S. T. (1998) · Acta Neuropathologica · doi:10.1007/s004010050792 · Cited by 229 · see citing works

Brain macrophages: questions of origin and interrelationship

Jordan, F. L., & Thomas, W. E. (1988) · Brain Research Reviews · doi:10.1016/0165-0173(88)90019-7 · Cited by 222 · see citing works

Accelerated Glial Reactivity to Stroke in Aged Rats Correlates with Reduced Functional Recovery

Badan, I., Buchhold, B., Hamm, A. O., Gratz, M., Walker, L. C., Platt, D., Kessler, C., & Popa‐Wagner, A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000071883.63724.a7 · Cited by 216 · see citing works

Increased microglial activation and protein nitration in white matter of the aging monkey☆

Sloane, J. A., Hollander, W., Moss, M. B., Rosene, D. L., & Abraham, C. R. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00066-4 · Cited by 208 · see citing works

The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction

Morgan, T. E., Xie, Z., Goldsmith, S., Yoshida, T., Lanzrein, A.-S., Stone, D., Rozovsky, I., Perry, G., Smith, M. A., & Finch, C. E. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00334-0 · Cited by 195 · see citing works

Effects of ageing on microglia in the normal rat brain: immunohistochemical observations

Ogura, K., Ogawa, M., & Yoshida, M. (1994) · Neuroreport · doi:10.1097/00001756-199406020-00016 · Cited by 181 · see citing works

Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits

Streit, W. J., & Sparks, D. L. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050097 · Cited by 168 · see citing works

Microglial Cell Activation in Aging and Alzheimer Disease: Partial Linkage with Neurofibrillary Tangle Burden in the Hippocampus

DIPATRE, P. L., & GELMAN, B. B. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199702000-00004 · Cited by 157 · see citing works

Functional outcomes of older adults with traumatic brain injury: A prospective, multicenter analysis

Cifu, D. X., Kreutzer, J. S., Marwitz, J. H., et al. (1996) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(96)90274-9 · Cited by 153 · see citing works

Microglial Turnover in the Injured CNS: Activated Microglia Undergo Delayed DNA Fragmentation Following Peripheral Nerve Injury

Gehrmann, J., & Banati, R. B. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199509000-00010 · Cited by 147 · see citing works

Intracerebral Hemorrhage

Gong, Y., Hua, Y., Keep, R. F., et al. (2004) · Stroke · doi:10.1161/01.str.0000145485.67827.d0 · Cited by 137 · see citing works

Autoradiographische Untersuchung �ber die Beteiligung von Gliazellen an der axonalen Reaktion im Facialiskern der Ratte

Kreutzberg, G. W. (1966) · Acta Neuropathologica · doi:10.1007/bf00686781 · Cited by 130 · see citing works

Effects of advancing age on peripheral nerve regeneration

Vaughan, D. W. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903230207 · Cited by 128 · see citing works

Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: Implications for the role of oxidative stress

Morgan, T. E., Rozovsky, I., Goldsmith, S. K., Stone, D. J., Yoshida, T., & Finch, C. E. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00120-2 · Cited by 126 · see citing works

Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury

Kyrkanides, S., O’Banion, M. K., Whiteley, P. E., Daeschner, J., & Olschowka, J. A. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00404-0 · Cited by 118 · see citing works

Wnt-1 dependent activation of the survival factor NF-?B in PC12 cells

Bournat, J. C., Brown, A. M. C., & Soler, A. P. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000701)61:1 · Cited by 100 · see citing works

TGF-β1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia

Chen, S., Luo, D., Streit, W. J., & Harrison, J. K. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00354-5 · Cited by 96 · see citing works

Long-Term Functional Status and Mortality of Elderly Patients with Severe Closed Head Injuries

Kilaru, S., Garb, J., Emhoff, T. A., Fiallo, V. M., Simon, B., Swiencicki, T., & Lee, K. F. (1996) · doi:10.1097/00005373-199612000-00003 · Cited by 94 · see citing works

Perineuronal glial responses after axotomy of central and peripheral axons. A comparison

Barron, K. D., Marciano, F. F., Amunson, R., & Mankes, R. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91490-8 · Cited by 92 · see citing works

Microglial activation, emergence of ED1-expressing cells and clusterin upregulation in the aging rat CNS, with special reference to the spinal cord

Kullberg, S., Aldskogius, H., & Ulfhake, B. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02222-3 · Cited by 76 · see citing works

Juxtavascular karyokinesis and microglia cell proliferation during retrograde reaction in the mouse facial nucleus.

Cammermeyer, J. (1965) · PubMed · Cited by 76 · see citing works

Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury

Stuesse, S. L., Cruce, W. L. R., Lovell, J. A., McBurney, D. L., & Crisp, T. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01142-3 · Cited by 68 · see citing works

Population control of microglia: does apoptosisplay a role?

Jones, L. L., Banati, R. B., Graeber, M. B., Bonfanti, L., Raivich, G., & Kreutzberg, G. W. (1997) · Journal of Neurocytology · doi:10.1023/a:1018514415073 · Cited by 68 · see citing works

Slow Axonal Regrowth But Extreme Hyperinnervation of Target Muscle After Suture of the Facial Nerve in Aged Rats

Streppel, M., Angelov, D. N., Guntinas‐Lichius, O., et al. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00163-2 · Cited by 60 · see citing works

The Effects of Age on the Cells in Layer 1 of Primate Cerebral Cortex

Peters, A. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.1.27 · Cited by 57 · see citing works

Neuronal susceptibility to damage: comparison of the retinas of young, old and old/caloric restricted rats before and after transient ischemia

Kim, K.-Y., Ju, W., & Neufeld, A. H. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.07.005 · Cited by 56 · see citing works

Molecular and cellular mediators of Alzheimer's disease inflammation

Strohmeyer, R., & Rogers, J. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3118 · Cited by 51 · see citing works

Perineuronal microglial reactivity following proximal and distal axotomy of rat rubrospinal neurons

Tseng, G., Wang, Y., & Lai, Q.-C. (1996) · Brain Research · doi:10.1016/0006-8993(95)01418-7 · Cited by 40 · see citing works

Microglia in the Regenerating and Degenerating Central Nervous System

Streit, W. (2002) · Springer: New York · doi:10.1007/978-1-4757-4139-1 · Cited by 36 · see citing works

A bromodeoxyuridine labelling study of proliferating cells in the brainstem following hypoglossal nerve transection.

Svensson, M. A., Mattsson, P., & Aldskogius, H. (1994) · PubMed · Cited by 36 · see citing works

Selective vulnerability of neocortical association areas in Alzheimer's disease

Giannakopoulos, P., Hof, P. R., & Bouras, C. (1998) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19981001)43:1 · Cited by 31 · see citing works

Facial nerve axotomy in aged and young adult rats: analysis of the glial response

Hurley, S. D. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00097-0 · Cited by 30 · see citing works

Quantitative immunohistochemistry in the rat facial nucleus with [125I]-iodinated secondary antibodies and in situ autoradiography: non-linear binding characteristics of primary monoclonal and polyclonal antibodies.

Raivich, G., Gehrmann, J., Graeber, M. B., et al. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.4.8450197 · Cited by 30 · see citing works

Effects of advancing age on the central response of rat facial neurons to axotomy: Light microscope morphometry

Vaughan, D. W. (1990) · The Anatomical Record · doi:10.1002/ar.1092280212 · Cited by 20 · see citing works

[Autoradiographic studies on perineuronal microgliocytes].

Kreutzberg, G. W. (1968) · PubMed · Cited by 16 · see citing works

Microglial Response in the Axotomized Facial Motor Nucleus

Raivich, G. (2002) · Springer eBooks · doi:10.1007/978-1-4757-4139-1_8 · Cited by 6 · see citing works

Microglial dysfunction in brain aging and Alzheimer's disease

Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618 · see citing works

Microglial cell dysregulation in brain aging and neurodegeneration

von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works

Microglial senescence: does the brain's immune system have an expiration date?

Streit, W. J. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.001 · Cited by 397 · see citing works

Microglial pathology

Streit, W. J., Xue, Q.-S., Tischer, J., & Bechmann, I. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0142-6 · Cited by 317 · see citing works

Microglia actions in Alzheimer's disease

Prokop, S., Miller, K. R., & Heppner, F. L. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1182-x · Cited by 291 · see citing works

Cellular senescence and the aging brain

Chinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J., & Andersen, J. K. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.018 · Cited by 282 · see citing works

Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders

Von Bernhardi, R., Tichauer, J. E., & Eugenín, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06537.x · Cited by 258 · see citing works

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

Kumar, A., Stoica, B. A., Sabirzhanov, B., Burns, M. P., Faden, A. I., & Loane, D. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.013 · Cited by 244 · see citing works

Microglia in the aging brain: relevance to neurodegeneration

Luo, X.-G., Ding, J.-Q., & Chen, S.-D. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-12 · Cited by 236 · see citing works

Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

Mangold, C. A., Wronowski, B., Du, M., Masser, D. R., Hadad, N., Bixler, G. V., Brucklacher, R. M., Ford, M. M., Sonntag, W. E., & Freeman, W. M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0920-8 · Cited by 203 · see citing works

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

Chinta, S. J., Lieu, C. A., DeMaria, M., Laberge, R. ‐., Campisi, J., & Andersen, J. K. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12029 · Cited by 165 · see citing works

Microglial degeneration in the aging brain - bad news for neurons?

Streit, W. (2008) · Frontiers in Bioscience · doi:10.2741/2937 · Cited by 150 · see citing works

The effects of aging, injury and disease on microglial function: a case for cellular senescence

Miller, K. R., & Streit, W. J. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x08000136 · Cited by 134 · see citing works

Are there roles for brain cell senescence in aging and neurodegenerative disorders?

Tan, F. C. C., Hutchison, E. R., Eitan, E., & Mattson, M. P. (2014) · Biogerontology · doi:10.1007/s10522-014-9532-1 · Cited by 116 · see citing works

Glial Cells and Integrity of the Nervous System

von Bernhardi, R., Eugenín-von Bernhardi, J., Flores, B., & Eugenín León, J. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-40764-7_1 · Cited by 67 · see citing works

DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

Schwab, N., Grenier, K., & Hazrati, L.-N. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0822-3 · Cited by 47 · see citing works

Regeneration‐associated genes decline in chronically injured rat sciatic motoneurons

Gordon, T., & Tetzlaff, W. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13070 · Cited by 39 · see citing works

The effects of postganglionic axotomy and nerve growth factor on the superior cervical ganglia of developing mice

Banks, B. E. C., & Walter, S. J. (1977) · Journal of Neurocytology · doi:10.1007/bf01175192 · Cited by 23 · see citing works

Reduced expression of regeneration associated genes in chronically axotomized facial motoneurons

Gordon, T., You, S., Cassar, S. L., & Tetzlaff, W. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.10.022 · Cited by 25 · see citing works

The effect of age on motor neurone death following axotomy in the mouse

Pollin, M. M., McHanwell, S., & Slater, C. R. (1991) · Development · doi:10.1242/dev.112.1.83 · Cited by 92 · see citing works

Growth Associated Protein-43 mRNA Expression in Nucleus Ambiguus Motoneurons after Recurrent Laryngeal Nerve Injury in the Rat

Uno, T., Shogaki, K., Bamba, H., et al. (2003) · Acta Oto-Laryngologica · doi:10.1080/00016480310001150 · Cited by 7 · see citing works