The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
Abstract
We have previously developed and characterized isolated microglia and astrocyte cultures from rapid (<4 h) brain autopsies of Alzheimer's disease (AD) and nondemented elderly control (ND) patients. In the present study, we evaluate the inflammatory repertoire of AD and ND microglia cultured from white matter (corpus callosum) and gray matter (superior frontal gyrus) with respect to three major proinflammatory cytokines, three chemokines, a classical pathway complement component, a scavenger cell growth factor, and a reactive nitrogen intermediate. Significant, dose‐dependent increases in the production of pro‐interleukin‐1β (pro‐IL‐1β), interleukin‐6 (IL‐6), tumor necrosis factor‐α (TNF‐α), monocyte chemoattractant protein‐1 (MCP‐1), macrophage inflammatory peptide‐1α (MIP‐1α), IL‐8, and macrophage colony‐stimulating factor (M‐CSF) were observed after exposure to pre‐aggregated amyloid β peptide (1–42) (Aβ1–42). Across constitutive and Aβ‐stimulated conditions, secretion of complement component C1q, a reactive nitrogen intermediate, and M‐CSF was significantly higher in AD compared with ND microglia. Taken together with previous in situ hybridization findings, these results demonstrate unequivocally that elderly human microglia provide a brain endogenous source for a wide range of inflammatory mediators. GLIA 35:72–79, 2001. © 2001 Wiley‐Liss, Inc.
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Cites
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
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Activation of microglial cells by β-amyloid protein and interferon-γ
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Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D. (1996) · Nature · doi:10.1038/382716a0 · Cited by 727
Lue, L.-F., Brachova, L., Civin, H. W., & Rogers, J. (1996) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199655100-00008 · Cited by 246 · cited 7×
“To address such difficulties, we have developed and characterized isolated microglia and astrocyte cultures from rapid (,4 h) brain autopsies of AD and nondemented elderly control (ND) patients (Lue et al., 1996b).”
BackgroundMethodInfluentialSelf-citationStoltzner, S. E., Grenfell, T. J., Mori, C., Wisniewski, K. E., Wisniewski, T. M., Selkoe, D. J., & Lemere, C. A. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64753-0 · Cited by 187
Cited by
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Role of Pro-Inflammatory Cytokines Released from Microglia in Neurodegenerative Diseases
Smith, J. A., Das, A., Ray, S. K., & Banik, N. L. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.10.004 · Cited by 1,165
Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
Wyss-Coray, T., & Rogers, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006346 · Cited by 975
Self-citationGodbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813
Inflammatory processes in Alzheimer's disease
Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782
Metadata
- Authors
- Lue, L., Rydel, R., Brigham, E. F., Yang, L., Hampel, H., Murphy, G. M., Brachova, L., Yan, S., Walker, D. G., Shen, Y., & Rogers, J.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2001-06-12
- Volume
- 35
- Issue
- 1
- Pages
- 72-79
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W1990636293
- Cited by
- 382
- References
- 6
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lue, L., Rydel, R., Brigham, E. F., Yang, L., Hampel, H., Murphy, G. M., Brachova, L., Yan, S., Walker, D. G., Shen, Y., & Rogers, J. (2001). Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia. https://doi.org/10.1002/glia.1072
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