Cited by 727Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

Khoury, Joseph El, Hickman, Suzanne E., Thomas, Christian A., Cao, Long, Silverstein, Samuel C., Loike, John D.·1996·Nature

Abstract

A pathological hallmark of Alzheimer's disease is the senile plaque, containing beta-amyloid fibrils, microglia and astrocytes. Beta-amyloid fibrils exert a cytotoxic effect on neurons, and stimulate microglia to produce neurotoxins, such as reactive oxygen species. Mononuclear phagocytes, including microglia, express scavenger receptors that mediate endocytosis of oxidized low-density lipoproteins, and adhesion to glucose-modified extra-cellular matrix proteins. Here we report that class A scavenger receptors mediate adhesion of rodent microglia and human monocytes to beta-amyloid fibril-coated surfaces leading to secretion of reactive oxygen species and cell immobilization. Thus, class A scavenger receptors are potential therapeutic targets in Alzheimer's disease.

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Crossref · 10.1038/382716a0

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21 of 21 references verified0 citation errors · 0 not checkable

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  • Aβ clearance involves microglial phagocytosis and endocytosis via scavenger receptors and extracellular degradation by Aβ-degrading enzymes.

    “Aβ clearance involves, in part36, phagocytosis and endocytosis via microglial scavenger receptors (SRs)37,38 and extracellular degradation by Aβ-degrading enzymes6,36.”

    From Microglia in neurodegeneration (2018) · cites this paper as [38]

  • Microglia around Aβ plaques in humans and Aβ-mice express SR-A1, a receptor that phagocytoses Aβ.

    “SR-A1 is an Aβ-phagocytic receptor37,38 expressed on microglia surrounding Aβ plaques in humans and Aβ-mice.”

    From Microglia in neurodegeneration (2018) · cites this paper as [38]

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Authors
Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D.
Affiliations
Columbia University (US)
Venue
Nature
Published
1996-08
Volume
382
Issue
6593
Pages
716-719
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2045560271
Cited by
727
References
21
Citations by year
2026: 5 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 18 · 2021: 19 · 2020: 20 · 2019: 15 · 2018: 12 · 2017: 10 · 2016: 18 · 2015: 21 · 2014: 20 · 2013: 22 · 2012: 31
FWCI
29.22
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords
scavenger receptors, scavenger receptor A, microglia, amyloid-beta fibrils, Alzheimer's disease, amyloid plaques, reactive oxygen species, monocytes, cell immobilization, therapeutic target
MeSH terms
Alzheimer Disease, Amino Acid Sequence, Animals, Cell Adhesion, Cell Line, Cell Movement, Collagen, Humans, Ligands, Membrane Proteins, Molecular Sequence Data, Monocytes, Peptides, Receptors, Immunologic, Amyloid beta-Peptides, Reactive Oxygen Species, Microglia, Receptors, Lipoprotein, Receptors, Scavenger, Scavenger Receptors, Class A, Scavenger Receptors, Class B, Mice, Rats

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