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Cited by 38Spinal Cord Injury ResearchNeurogenesis and neuroplasticity mechanismsNerve injury and regeneration

Effects of axon degeneration on oligodendrocyte lineage cells: Dorsal rhizotomy evokes a repair response while axon degeneration rostral to spinal contusion induces both repair and apoptosis

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Sun, Fang, Lin, Chien‐Liang Glenn, Mctigue, Dana, Shan, Xiu, Tovar, C. Amy, Bresnahan, Jacqueline C., Beattie, Michael S.·2010·Glia
DOI 10.1002/glia.21009PMC PMC3045846
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Abstract

Wallerian degeneration in the dorsal columns (DC) after spinal cord injury (SCI) is associated with microglial activation and prolonged oligodendrocyte (OL) apoptosis that may contribute to demyelination and dysfunction after SCI. But, there is an increase in OL lineage cells after SCI that may represent a reparative response, and there is evidence for remyelination after SCI. To assess the role of axonal degeneration per se in OL apoptosis and proliferation, we cut the L2‐S2 dorsal roots producing massive axonal degeneration and microglial activation in the DC, and found no evidence of OL loss or apoptosis. Rather, the numbers of OL‐lineage cells positive for NG2 and APC (CC1) increased, and BrdU studies suggested new OL formation. We then tested contusion SCI (cSCI) that results in comparable degeneration in the DC rostral to the injury, microglial activation, and apoptosis of DC OLs by eight days. NG2+ cell proliferation and oligodendrogenesis was seen as after rhizotomy. The net result of this combination of proliferation and apoptosis was a reduction in DC OLs, confirming earlier studies. Using an antibody to oxidized nucleic acids, we found rapid and prolonged RNA oxidation in OLs rostral to cSCI, but no evidence of oxidative stress in DC OLs after rhizotomy. These results suggest that signals associated with axonal degeneration are sufficient to induce OL proliferation, and that secondary injury processes associated with the central SCI, including oxidative stress, rather than axonal degeneration per se , are responsible for OL apoptosis. © 2010 Wiley‐Liss, Inc.

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  • Immediately after injury the spinal cord undergoes massive cellular and molecular changes, including increased cell death, infiltration of inflammation cells, axon degeneration, and OL and myelin loss.

    “Immediately after injury the spinal cord undergoes massive cellular and molecular changes, including increased cell death [64, 65], infiltration of inflammation cells in the lesion [2–6], axon degeneration [7–10], and OL and myelin loss [13–16, 66, 67].”

    From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [9]

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Authors
Sun, F., Lin, C. G., Mctigue, D., Shan, X., Tovar, C. A., Bresnahan, J. C., & Beattie, M. S.
Affiliations
  • Boston Children's Hospital (US)
  • The Ohio State University (US)
  • Johns Hopkins University (US)
  • University of California, San Francisco (US)
Corresponding author
Beattie, Michael S.
ORCID
Venue
Glia
Publisher
Wiley
Published
2010-05-05
Volume
58
Issue
11
Pages
1304-1319
ISSN
  • 0894-1491 (ISSN-L)
  • 1098-1136
DOI
10.1002/glia.21009
PMC
PMC3045846
OpenAlex
W2125306175
Cited by
38
References
5
Citations by year
2026: 1 · 2025: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Glia (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NYS CoRE (C019722)
  • NIH (NS-31193, NS-38079, AG032518, AG027797)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
axonal degeneration, Wallerian degeneration, oligodendrocyte apoptosis, oligodendrocyte lineage, dorsal rhizotomy, spinal cord contusion, dorsal columns, microglial activation, oligodendrocyte precursor cells, oligodendrogenesis, RNA oxidation, oxidative stress, demyelination, remyelination, secondary injury
MeSH terms
Animals, Axons, Disease Models, Animal, Female, Oligodendroglia, Spinal Cord Injuries, Stem Cells, Wallerian Degeneration, Apoptosis, Rhizotomy, Cell Lineage, Recovery of Function, Rats, Long-Evans, Rats

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