bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS
Abstract
Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.
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In OPCs, there was early upregulation of several transcription factors and Notch ligands known to regulate differentiation to oligodendrocytes after loss of surrounding oligodendrocytes.
“In OPCs, there was early upregulation of several transcription factors (OLIG1, OLIG2, SOX10, SOX8, PRRX1, ASCL1) and Notch ligands (DLL1, DLL3) known to regulate differentiation78–81 to oligodendrocytes after loss of surrounding oligodendrocytes (Fig. 7e, right, and Fig. 7g).”
From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [78]
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- Authors
- Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Arnett, Heather A.
- Fancy, Stephen P. J.
- Franklin, Robin J. M.
- Stiles, Charles D.
- ORCID
- Venue
- Science
- Published
- 2004-12-17
- Volume
- 306
- Issue
- 5704
- Pages
- 2111-2115
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064769936
- Cited by
- 416
- References
- 28
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 13 · 2020: 17 · 2019: 21 · 2018: 10 · 2017: 16 · 2016: 15 · 2015: 26 · 2014: 35 · 2013: 26 · 2012: 16
- FWCI
- 15.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Multiple Sclerosis Society
- National Institute of Neurological Disorders and Stroke (NS-08952, NS-11920, NS4051, R01NS008952)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- Olig1, Olig2, bHLH transcription factors, demyelination, multiple sclerosis, myelinating oligodendrocytes, oligodendrocyte precursor cells, central nervous system repair
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Animals, Newborn, Brain, Cell Nucleus, Cuprizone, Cytoplasm, Demyelinating Diseases, DNA-Binding Proteins, Ethidium, Humans, Lysophosphatidylcholines, Mice, Inbred C57BL, Multiple Sclerosis, Myelin Sheath, Nerve Tissue Proteins, Oligodendroglia, Spinal Cord, Stem Cells, Transcription Factors, Rats, Sprague-Dawley, Mice, Rats, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors
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