The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Working memory in early Alzheimer's disease: a neuropsychological review
Open accessAbstract
Background: Reports of the extent of working memory (WM) impairment in early Alzheimer's disease (AD) have been inconsistent. Using the model of WM proposed by Baddeley, neuropsychological evidence for the impairment of WM in early AD is evaluated. Method: Literature searches were performed using Medline, PsycINFO and Embase databases. Individual papers were then examined for additional references not revealed by computerised searches. Results: Phonological loop function is intact at the preclinical and early stages of AD, becoming more impaired as the disease progresses. In mild AD, there is impairment on tasks assessing visuospatial sketchpad (VSS) function; however, these tasks also require executive processing by the central executive system (CES). There is evidence that the CES is impaired in mild AD and may be affected in the earlier preclinical stage of the disease. Episodic buffer function may be impaired but further research is required. Conclusions: Future research into central executive functioning at the earliest stages of the disease, combined with further longitudinal studies, needs to be carried out. Tasks to assess the proposed functions of the episodic buffer and specific tests of the VSS suitable for AD subjects need to be developed and validated. Learning more about these processes and how they are affected in AD is important in understanding and managing the cognitive deficits seen in the early stages of AD. Copyright © 2009 John Wiley & Sons, Ltd.
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Cites
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Cited by
Modelling neural correlates of working memory: A coordinate-based meta-analysis
Rottschy, C., Langner, R., Dogan, I., Reetz, K., Laird, A. R., Schulz, J. B., Fox, P. T., & Eickhoff, S. B. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.050 · Cited by 951
GWAS for executive function and processing speed suggests involvement of the CADM2 gene
Ibrahim-Verbaas, C. A., Bressler, J., Debette, S., Schuur, M., Smith, A. V., Bis, J. C., Davies, G., Trompet, S., Smith, J. A., Wolf, C., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.37 · Cited by 147
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Stevens, L. M., & Brown, R. E. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.033 · Cited by 92
Ahmed, S. F., Ellis, A., Ward, K. P., Chaku, N., & Davis-Kean, P. E. (2022) · Developmental Psychology · doi:10.1037/dev0001396 · Cited by 84
Metadata
- Authors
- Huntley, J. D., & Howard, R. J.
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2009-08-11
- Volume
- 25
- Issue
- 2
- Pages
- 121-132
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- OpenAlex
- W1986653173
- Cited by
- 222
- References
- 12
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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