Cognitive improvement following benzodiazepine discontinuation in elderly nursing home residents
Abstract
In a controlled study, benzodiazepine treatment was gradually discontinued from a group of elderly nursing home residents. In comparison with similar residents who continued on benzodiazepines, measures of memory and cognitive functioning showed significant improvement following discontinuance. There was no associated increase in anxiety, agitation, or sleeplessness. These data are consistent with previous observations suggesting that benzodiazepines impair cognitive function in the elderly and further indicate that such impairment is reversible upon benzodiazepine discontinuance.
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Salzman et al. (1992) reported that cognitive impairment in nursing home residents was reversed after withdrawal.
“Salzman, Fisher, Nobel, and Glassman (1992) reported that cognitive impairment observed in their samples of 13 nursing home residents was reversed after withdrawal as compared to the 12 residents who did not withdraw.”
From Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: a meta-analysis (2004) · cites this paper as Salzman, Fisher, Nobel, and Glassman (1992)
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- Authors
- Salzman, C., Fisher, J., Nobel, K., Glassman, R., Wolfson, A., & Kelley, M.
- Affiliations
- Harvard University (US)
- ORCID
- Salzman, Carl
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 1992-02
- Volume
- 7
- Issue
- 2
- Pages
- 89-93
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- OpenAlex
- W2092914302
- Cited by
- 117
- References
- 0
- Citations by year
- 2025: 4 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 9 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 8 · 2013: 4 · 2012: 4
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- benzodiazepines, benzodiazepine discontinuation, cognitive impairment, memory, older adults, nursing home residents, anxiety, agitation, insomnia
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