CoChat
Sign Up
Cited by 264Optical Imaging and Spectroscopy TechniquesAdvanced MRI Techniques and ApplicationsSpectroscopy Techniques in Biomedical and Chemical Research

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Simultaneous measurements of cerebral oxygenation changes during brain activation by near-infrared spectroscopy and functional magnetic resonance imaging in healthy young and elderly subjects

Open access
Mehagnoul‐Schipper, D. Jannet, van der Kallen, Bas F.W., Colier, Willy N.J.M., van der Sluijs, Marco C., van Erning, Leon J.Th.O., Thijssen, Henk O.M., Oeseburg, Berend, Hoefnagels, Willibrord H.L., Jansen, René W.M.M.·2002·Human Brain Mapping
DOI 10.1002/hbm.10026PMC PMC6871837
Open this paper in CoChat — free account

Abstract

Near infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI) both allow non-invasive monitoring of cerebral cortical oxygenation responses to various stimuli. To compare these methods in elderly subjects and to determine the effect of age on cortical oxygenation responses, we determined motor-task-related changes in deoxyhemoglobin concentration ([HHb]) over the left motor cortex in six healthy young subjects (age 35 +/- 9 years, mean +/- SD) and five healthy elderly subjects (age 73 +/- 3 years) by NIRS and blood-oxygen-level-dependent (BOLD) fMRI simultaneously. The motor-task consisted of seven cycles of 20-sec periods of contralateral finger-tapping at a rate as fast as possible alternated with 40-sec periods of rest. Time-locked averages over the seven cycles were used for further analysis. Task-related decreases in [HHb] over the motor cortex were measured by NIRS, with maximum changes of -0.83 +/- 0.38 mumol/L (P < 0.01) for the young and -0.32 +/- 0.17 mumol/L (P < 0.05) for the elderly subjects. The BOLD-fMRI signal increased over the cortex volume under investigation with NIRS, with maximum changes of 2.11 +/- 0.72% (P < 0.01) for the young and 1.75 +/- 0.71% (P < 0.01) for the elderly subjects. NIRS and BOLD-fMRI measurements showed good correlation in the young (r = -0.70, r(2) = 0.48, P < 0.001) and elderly subjects (r = -0.82, r(2) = 0.67, P < 0.001). Additionally, NIRS measurements demonstrated age-dependent decreases in task-related cerebral oxygenation responses (P < 0.05), whereas fMRI measurements demonstrated smaller areas of cortical activation in the elderly subjects (P < 0.05). These findings demonstrate that NIRS and fMRI similarly assess cortical oxygenation changes in young subjects and also in elderly subjects. In addition, cortical oxygenation responses to brain activation alter with aging.

Overview

Integrity signals

Registry

Crossref · 10.1002/hbm.10026

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 38 references

Cited by

Sorted by citations

Items 201–262 of 262

Related

See all

Metadata

Authors
Mehagnoul‐Schipper, D. J., van der Kallen, B. F. W., Colier, W. N. J. M., van der Sluijs, M. C., van Erning, L. J. T. O., Thijssen, H. O. M., Oeseburg, B., Hoefnagels, W. H. L., & Jansen, R. W. M. M.
ORCID
Venue
Human Brain Mapping
Publisher
Wiley
Published
2002-01-30
Volume
16
Issue
1
Pages
14-23
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
DOI
10.1002/hbm.10026
PMC
PMC6871837
OpenAlex
W2038514443
Cited by
264
References
38
Citations by year
2026: 3 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 12 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 7 · 2015: 14 · 2014: 11 · 2013: 14 · 2012: 16
FWCI
12.62
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Human Brain Mapping (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
Keywords
near-infrared spectroscopy, functional MRI, cerebral oxygenation, deoxyhemoglobin, aging, motor cortex activation, finger tapping, BOLD signal, method comparison, cortical activation, elderly subjects
MeSH terms
Adult, Aged, Cerebrovascular Circulation, Female, Fingers, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Motor Cortex, Movement, Oxygen Consumption, Predictive Value of Tests, Psychomotor Performance, Time Factors, Reproducibility of Results, Spectroscopy, Near-Infrared

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review