The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Abnormal activation of the social brain during face perception in autism
Open accessAbstract
ASD involves a fundamental impairment in processing social‐communicative information from faces. Several recent studies have challenged earlier findings that individuals with autism spectrum disorder (ASD) have no activation of the fusiform gyrus (fusiform face area, FFA) when viewing faces. In this study, we examined activation to faces in the broader network of face‐processing modules that comprise what is known as the social brain. Using 3T functional resonance imaging, we measured BOLD signal changes in 10 ASD subjects and 7 healthy controls passively viewing nonemotional faces. We replicated our original findings of significant activation of face identity‐processing areas (FFA and inferior occipital gyrus, IOG) in ASD. However, in addition, we identified hypoactivation in a more widely distributed network of brain areas involved in face processing [including the right amygdala, inferior frontal cortex (IFC), superior temporal sulcus (STS), and face‐related somatosensory and premotor cortex]. In ASD, we found functional correlations between a subgroup of areas in the social brain that belong to the mirror neuron system (IFC, STS) and other face‐processing areas. The severity of the social symptoms measured by the Autism Diagnostic Observation Schedule was correlated with the right IFC cortical thickness and with functional activation in that area. When viewing faces, adults with ASD show atypical patterns of activation in regions forming the broader face‐processing network and social brain, outside the core FFA and IOG regions. These patterns suggest that areas belonging to the mirror neuron system are involved in the face‐processing disturbances in ASD. Hum Brain Mapp, 2007. © 2006 Wiley‐Liss, Inc.
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Cites
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Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Harms, M. B., Martin, A., & Wallace, G. L. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9138-6 · Cited by 1,028
Mapping early brain development in autism
Courchesne, E., Pierce, K., Schumann, C. M., Redcay, E., Buckwalter, J. A., Kennedy, D. P., & Morgan, J. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.016 · Cited by 860
Brain basis of human social interaction: from concepts to brain imaging
Hari, R., & Kujala, M. V. (2009) · Physiological Reviews · doi:10.1152/physrev.00041.2007 · Cited by 638
Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function
Seminowicz, D. A., Wideman, T. H., Naso, L., Hatami-Khoroushahi, Z., Fallatah, S., Ware, M. A., Jarzem, P., Bushnell, M. C., Shir, Y., Ouellet, J. A., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5280-10.2011 · Cited by 622
Metadata
- Authors
- Hadjikhani, N., Joseph, R. M., Snyder, J., & Tager‐Flusberg, H.
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2006-11-28
- Volume
- 28
- Issue
- 5
- Pages
- 441-449
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- OpenAlex
- W1973118694
- Cited by
- 297
- References
- 17
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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