Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders
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To examine mirror neuron abnormalities in autism, high-functioning children with autism and matched controls underwent fMRI while imitating and observing emotional expressions. Although both groups performed the tasks equally well, children with autism showed no mirror neuron activity in the inferior frontal gyrus (pars opercularis). Notably, activity in this area was inversely related to symptom severity in the social domain, suggesting that a dysfunctional 'mirror neuron system' may underlie the social deficits observed in autism.
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These difficulties have been associated with anatomical and functional differences in the empathy network.
“These difficulties have been associated with anatomical and functional differences in the empathy network5–10.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [10]
Morphological studies have generally reported increased caudate volume in ASD.
“Morphological studies have generally reported increased caudate volume in ASD (37;38).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [38]
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- Authors
- Dapretto, M., Davies, M. S., Pfeifer, J. H., Scott, A. A., Sigman, M., Bookheimer, S. Y., & Iacoboni, M.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Dapretto, Mirella
- Venue
- Nature Neuroscience
- Published
- 2005-12-04
- Volume
- 9
- Issue
- 1
- Pages
- 28-30
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3713227
- OpenAlex
- W2031371003
- Cited by
- 1,694
- References
- 16
- Citations by year
- 2026: 23 · 2025: 30 · 2024: 78 · 2023: 37 · 2022: 56 · 2021: 60 · 2020: 106 · 2019: 58 · 2018: 74 · 2017: 75 · 2016: 71 · 2015: 89 · 2014: 108 · 2013: 107 · 2012: 124
- FWCI
- 109.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Research Resources (RR08655, P41RR013642, RR 13642, C06RR012169)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035470, P50HD055784)
- Topics
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- autism spectrum disorder, mirror neuron system, social cognition, social dysfunction, inferior frontal gyrus, pars opercularis, symptom severity, children
- MeSH terms
- Autistic Disorder, Brain Mapping, Child, Emotions, Empathy, Facial Expression, Female, Humans, Magnetic Resonance Imaging, Male, Neurons, Social Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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