Association between white matter fiber structure and reward‐related reactivity of the ventral striatum
Open accessAbstract
Individual responsiveness to rewards or rewarding stimuli may affect various domains of normal as well as pathological behavior. The ventral striatum/nucleus accumbens (NAcc) constitutes a key brain structure in the regulation of reward‐appetitive behavior. It remains unclear, however, to which extent individual reward‐related BOLD response in the NAcc is dependent on individual characteristics of connecting white matter fiber tracts. Using tract‐based spatial statistics (TBSS) and statistical parametric mapping (SPM) this combined DTI ‐ fMRI study investigated this question by correlating NAcc BOLD signal upon receipt of a monetary reward with different white matter characteristics (FA, axial diffusivity, radial diffusivity). The results show that increased integrity of white matter as assessed by FA in the cingulate and corpus callosum, the inferior fronto‐occipital fasciculus, the anterior thalamic radiation and the anterior limb of the internal capsule was positively correlated with reward‐related activation in the NAcc. There were no negative correlations as well as no significant results regarding axial and radial diffusivity. These findings indicate that microstructural properties of fiber tracts connecting, amongst others, the cortex with the striatum may influence intensity of reward‐related responsiveness of the ventral striatum by constraining or increasing efficiency in information transfer within relevant circuitries involved in processing of reward. Hum Brain Mapp 35:1469–1476, 2014. © 2013 Wiley Periodicals, Inc.
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Increased integrity of white matter in the corpus callosum and internal capsule is positively associated with activation in the nucleus accumbens.
“Increased integrity of white matter in the corpus callosum and internal capsule has been found to be positively associated with activation in the nucleus accumbens [84].”
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Cites
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Training of Working Memory Impacts Structural Connectivity
Takeuchi, H., Sekiguchi, A., Taki, Y., Yokoyama, S., Yomogida, Y., Komuro, N., Yamanouchi, T., Suzuki, S., & Kawashima, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4611-09.2010 · Cited by 531 · see citing works
The neural substrates of reward processing in humans: the modern role of FMRI
McClure, S. M., York, M. K., & Montague, P. R. (2004) · The Neuroscientist · doi:10.1177/1073858404263526 · Cited by 480 · cited 2× · see citing works
“…orbital frontal cortex (OFC), medial prefrontal cortex (MPFC), amygdala, insula and the ventral striatum has been identified—all areas innervated by mesolimbic dopamine projections [Camara et al., 2009; Cauda et al., 2011; Knutson et al., 2003; McClure et al., 2004; Yacubian et al., 2006].”
BackgroundPrediction error as a linear function of reward probability is coded in human nucleus accumbens
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Imbalanced Neural Responsivity to Risk and Reward Indicates Stress Vulnerability in Humans
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“Amongst these, the nucleus accumbens (NAcc) constituting a major portion of the ventral striatum and receiving direct mesolimbic projections from the ventral tegmental area (VTA) has been proposed as the key brain structure in the regulation of reward-appetitive behavior [Admon et al., 2013; Camara et al., 2009; Cohen…”
BackgroundFunctional connectivity of reward processing in the brain
Camara, E. (2008) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.019.2008 · Cited by 141 · see citing works
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The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders
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- Authors
- Koch, K., Wagner, G., Schachtzabel, C., Schultz, C. C., Güllmar, D., Reichenbach, J. R., Sauer, H., Zimmer, C., & Schlösser, R. G. M.
- Affiliations
- TUM Klinikum (DE)
- Jena University Hospital (DE)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2013-04-24
- Volume
- 35
- Issue
- 4
- Pages
- 1469-1476
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6869599
- OpenAlex
- W1761882001
- Cited by
- 42
- References
- 7
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 3 · 2013: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- ventral striatum, nucleus accumbens, reward processing, white matter microstructure, fractional anisotropy, corpus callosum, cingulate cortex, inferior fronto-occipital fasciculus, anterior thalamic radiation, internal capsule, individual differences, monetary rewards, diffusion tensor imaging, functional MRI
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Neural Pathways, Neuropsychological Tests, Oxygen, Probability, Reward, Diffusion Tensor Imaging, Ventral Striatum
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