Imbalanced Neural Responsivity to Risk and Reward Indicates Stress Vulnerability in Humans
Abstract
Trauma-related psychopathology has been associated with an intense emotional reaction to stressful event. Emotional responses have evolved to signal the presence of risks to be avoided or of rewards to be approached in the environment. Thus, individuals' sensitivity to signals of risk and reward may affect the level of stress vulnerability. Stress, however, can modify these sensitivities as well. In the current functional magnetic resonance imaging (fMRI) study, we prospectively probed the neural correlates of such sensitivities in 24 healthy soldiers by using an interactive game that encompasses risky and rewarding intervals both pre-exposure and post-exposure to stressful military service. As expected, risky and rewarding intervals elicited selective responses in the amygdala and nucleus accumbens (Nacc), respectively. Furthermore, increased post-traumatic stress disorder symptoms post-exposure (i.e., stress vulnerability) corresponded to greater amygdala's response to risk both pre-exposure and post-exposure and to decreased NAcc response to reward only post-exposure. By combining these regional responsivities post-exposure, we accurately identified all the most vulnerable soldiers. Imbalanced neural responsivity to risk and reward following exposure to stress may therefore constitute a marker for stress vulnerability. Such identification of vulnerability biomarkers can aid future diagnostic and therapeutic efforts by allowing early detection of vulnerability as well as follow up on patient's treatment progression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increased risk of PTSD development is associated with dysregulations of central fear responses prior to and shortly after trauma exposure.
“An increased risk of PTSD development is associated with pre-existing dysregulations of (para)sympathetic [17,18] and hypothalamic-pituitary-adrenal axes [20,21], as well as dysregulations of central fear responses prior to [22] and shortly after trauma exposure [23,24].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [22]
Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032 · see citing works
(2005) · Springer eBooks · doi:10.1007/0-387-27255-0_9 · Cited by 20,333 · see citing works
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
The reward circuit: linking primate anatomy and human imaging
Haber, S. N., & Knutson, B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.129 · Cited by 3,718 · see citing works
(1985) · Cited by 2,882 · see citing works
Foa, E. B., Cashman, L., Jaycox, L., & Perry, K. (1997) · Psychological Assessment · doi:10.1037/1040-3590.9.4.445 · Cited by 2,709 · see citing works
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357 · see citing works
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129 · see citing works
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083 · cited 3× · see citing works
“Retrospective neuroimaging studies, however, cannot attribute neuronal indicators of functional abnormalities to acquired versus predisposed stress vulnerabilities (Shin and Liberzon 2010).”
BackgroundDepue, R. A., & Collins, P. F. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002046 · Cited by 2,046 · see citing works
Puzzlingly High Correlations in fMRI Studies of Emotion, Personality, and Social Cognition
Vul, E., Harris, C., Winkielman, P., & Pashler, H. (2009) · Perspectives on Psychological Science · doi:10.1111/j.1745-6924.2009.01125.x · Cited by 1,475 · cited 1× · see citing works
“Notably, ROI identification and selection was ''blind'' to the level of stress vulnerability (i.e., post-exposure PTSDrelated symptoms), thus avoiding any statistical bias between wholebrain and ROI analyses (Vul et al. 2009).”
BackgroundA two-dimensional neuropsychology of defense: fear/anxiety and defensive distance
McNaughton, N., & Corr, P. J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.005 · Cited by 1,308 · see citing works
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232 · see citing works
The human amygdala and the emotional evaluation of sensory stimuli
Zald, D. H. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00248-5 · Cited by 1,062 · see citing works
Emotion, cognition, and decision making
Schwarz, N. (2000) · Cognition & Emotion · doi:10.1080/026999300402745 · Cited by 894 · see citing works
Organization of projections from the medial nucleus of the amygdala: A PHAL study in the rat
Canteras, N. S., Simerly, R. B., & Swanson, L. W. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903600203 · Cited by 884 · see citing works
Pruessner, J. C., Champagne, F., Meaney, M. J., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3422-03.2004 · Cited by 709 · see citing works
The functional neuroanatomy of PTSD: a critical review
Liberzon, I., & Sripada, C. S. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67011-3 · Cited by 594 · see citing works
Fales, C. L., Barch, D. M., Rundle, M. M., Mintun, M. A., Snyder, A. Z., Cohen, J. D., Mathews, J., & Sheline, Y. I. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.012 · Cited by 517 · see citing works
Anticipatory anxiety and risk perception
Butler, G., & Mathews, A. (1987) · Cognitive Therapy and Research · doi:10.1007/bf01183858 · Cited by 365 · see citing works
Morrison, S. E., & Salzman, C. D. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.02.007 · Cited by 341 · see citing works
Linking nucleus accumbens dopamine and blood oxygenation
Knutson, B., & Gibbs, S. E. B. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0686-7 · Cited by 337 · see citing works
The role of the striatum in aversive learning and aversive prediction errors
Delgado, M. R., Li, J., Schiller, D., & Phelps, E. A. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0161 · Cited by 328 · see citing works
Stress, depression and the mesolimbic dopamine system
Cabib, S., & Puglisi‐Allegra, S. (1996) · Psychopharmacology · doi:10.1007/s002130050142 · Cited by 314 · see citing works
The neurobiology of individual differences in complex behavioral traits
Hariri, A. R. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135335 · Cited by 273 · see citing works
Focal brain damage protects against post-traumatic stress disorder in combat veterans
Koenigs, M., Huey, E. D., Raymont, V., Cheon, B., Solomon, J., Wassermann, E. M., & Grafman, J. (2008) · Nature Neuroscience · doi:10.1038/nn2032 · Cited by 255 · see citing works
Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity
Admon, R., Lubin, G., Stern, O., Rosenberg, K., Lee, S.-L., Ben-Ami, H., & Hendler, T. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0903183106 · Cited by 250 · see citing works
Self-citationHaas, B. W., Omura, K., Constable, R. T., & Canli, T. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.249 · Cited by 242 · see citing works
Psychological mechanisms in acute response to trauma
McNally, R. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01663-3 · Cited by 211 · see citing works
Post-traumatic stress disorder and depression: An analysis of comorbidity
Bleich, A., Koslowsky, M., Dolev, A., & Lerer, B. (1997) · British Journal of Psychiatry · doi:10.1192/bjp.170.5.479 · Cited by 211 · see citing works
Sailer, U., Robinson, S., Fischmeister, F. P. S., König, D., Oppenauer, C., Lueger-Schuster, B., Moser, E., Kryspin-Exner, I., & Bauer, H. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.05.022 · Cited by 201 · see citing works
Perceived threat predicts the neural sequelae of combat stress
van Wingen, G. A., Geuze, E., Vermetten, E., & Fernández, G. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.132 · Cited by 173 · see citing works
Psychopathology following trauma: The role of subjective experience
Creamer, M. C., McFARLANE, A. C., & Burgess, P. M. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.01.015 · Cited by 172 · see citing works
Elman, I., Lowen, S., Frederick, B. B., Chi, W., Becerra, L., & Pitman, R. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.006 · Cited by 165 · see citing works
The Role of the Amygdala in Signaling Prospective Outcome of Choice
Kahn, I., Yeshurun, Y., Rotshtein, P., Fried, I., Ben-Bashat, D., & Hendler, T. (2002) · Neuron · doi:10.1016/s0896-6273(02)00626-8 · Cited by 141 · see citing works
Self-citationSmillie, L. D. (2008) · European Journal of Personality · doi:10.1002/per.674 · Cited by 121 · see citing works
Effects of stress and corticosterone on activity and plasticity in the amygdala
Kavushansky, A., & Richter‐Levin, G. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21058 · Cited by 106 · see citing works
Epidemiology of trauma and posttraumatic stress disorder.
Breslau, N. (1998) · Cited by 101 · see citing works
Ultrastructure of the stomatogastric ganglion neuropil of the crab, Cancer borealis
Kilman, V. L., & Marder, E. E. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961021)374:3 · Cited by 81 · see citing works
Stevenson, C. W., & Gratton, A. P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02560.x · Cited by 69 · see citing works
Brain Activity Dissociates Mentalization from Motivation During an Interpersonal Competitive Game
Assaf, M., Kahn, I., Pearlson, G. D., Johnson, M. R., Yeshurun, Y., Calhoun, V. D., & Hendler, T. (2008) · Brain Imaging and Behavior · doi:10.1007/s11682-008-9047-y · Cited by 48 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Post-Traumatic Stress Disorder
Shalev, A. Y., Liberzon, I., & Marmar, C. R. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1612499 · Cited by 799 · see citing works
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620 · see citing works
“…dysregulations of the autonomic nervous system, hypothalamic—pituitary— adrenal (HPA) axis and central fear response, as well as a lack of perceived social support early after trauma (Admon et al., 2013; Apfel et al., 2011; Ozer et al., 2003; Shaikh al et al., 2012; van Zuiden et al., 2011).”
BackgroundOkon-Singer, H., Hendler, T., Pessoa, L., & Shackman, A. J. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00058 · Cited by 371 · see citing works
“Prospective designs (e.g., before and after exposure to a negative life event or trauma) would provide another powerful approach for understanding the plasticity of emotional attention (Admon et al., 2009, 2012).”
BackgroundSelf-citationHanson, J. L., Hariri, A. R., & Williamson, D. E. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.010 · Cited by 338 · see citing works
“striatal interactions after stress exposure (26), we examined task-based functional connectivity”
BackgroundMethodMcCrory, E. J., & Viding, E. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000115 · Cited by 295 · see citing works
“For example, van Wingen, Geuze, Vermetten, and Fernández, (2011) have demonstrated that stress exposure incurred following combat alters the functional properties of both the amygdala and anterior insula (see also Admon et al., 2009, 2013).”
BackgroundResultInfluentialAdmon, R., Milad, M. R., & Hendler, T. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.05.005 · Cited by 269 · see citing works
Self-citationThe Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span
Feder, A., Fred-Torres, S., Southwick, S. M., & Charney, D. S. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.012 · Cited by 269 · see citing works
Reward functioning in PTSD: a systematic review exploring the mechanisms underlying anhedonia
Nawijn, L., van Zuiden, M., Frijling, J. L., Koch, S. B. J., Veltman, D. J., & Olff, M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.019 · Cited by 250 · see citing works
Reduced nucleus accumbens reactivity and adolescent depression following early-life stress
Goff, B., Gee, D. G., Telzer, E. H., Humphreys, K. L., Gabard-Durnam, L., Flannery, J., & Tottenham, N. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.010 · Cited by 234 · see citing works
Understanding resilience: New approaches for preventing and treating PTSD
Horn, S. R. G.-V., Charney, D. S., & Feder, A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.002 · Cited by 223 · see citing works
“Longitudinal studies in soldiers incorporating brain imaging predeployment have also begun to identify differences associated with resilience and vulnerability post-deployment (Admon et al., 2013, Geuze et al., 2012).”
BackgroundDillon, D. G., Rosso, I. M., Pechtel, P., Killgore, W. D. S., Rauch, S. L., & Pizzagalli, D. A. (2014) · Depression and Anxiety · doi:10.1002/da.22202 · Cited by 209 · see citing works
“,[121] by permission of Oxford University Press.”
ResultMusical pleasure and reward: mechanisms and dysfunction
Zatorre, R. J. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12677 · Cited by 194 · see citing works
Stevens, J. S., Kim, Y. J., Galatzer-Levy, I. R., Reddy, R., Ely, T. D., Nemeroff, C. B., Hudak, L. A., Jovanovic, T., Rothbaum, B. O., & Ressler, K. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.015 · Cited by 177 · see citing works
“(14,15) found that greater amygdala reactivity before combat deployment predicted greater PTSD symptoms after deployment.”
BackgroundReliability of the electrocortical response to gains and losses in the doors task
Levinson, A. R., Speed, B. C., Infantolino, Z. P., & Hajcak, G. (2017) · Psychophysiology · doi:10.1111/psyp.12813 · Cited by 152 · see citing works
Posttraumatic stress disorder: A metabolic disorder in disguise?
Michopoulos, V., Vester, A., & Neigh, G. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.038 · Cited by 152 · see citing works
Understanding Resilience and Preventing and Treating PTSD
Horn, S. R. G.-V., & Feder, A. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000194 · Cited by 150 · see citing works
“to reward in the nucleus accumbens in a longitudinal study of healthy soldiers.(129) Stress-induced reward-system dysregulation is thought to increase vulnerability to stress-related disorders(49,53)—an observation that has been further supported by candidate-gene studies.”
BackgroundResultNeurobiology of comorbid post‐traumatic stress disorder and alcohol‐use disorder
Gilpin, N. W., & Weiner, J. L. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12349 · Cited by 147 · see citing works
“…focused solely on the epidemiology, neurobiology and treatment of each disorder alone, the interested reader is directed to the following PTSD (Admon et al. 2013b; Atwoli et al. 2015; Hoskins et al. 2015; Pitman et al. 2012) and AUD reviews (Batman & Miles 2015; Koob 2013; Samochowiec et al.…”
BackgroundAndrewes, D., & Jenkins, L. (2019) · Neuropsychology Review · doi:10.1007/s11065-019-09398-4 · Cited by 138 · see citing works
AMYGDALA RESPONSE TO NEGATIVE STIMULI PREDICTS PTSD SYMPTOM ONSET FOLLOWING A TERRORIST ATTACK
McLaughlin, K. A., Busso, D. S., Duys, A., Green, J. G., Alves, S., Way, M., & Sheridan, M. A. (2014) · Depression and Anxiety · doi:10.1002/da.22284 · Cited by 146 · see citing works
“Predeployment amygdala recruitment predicts PTSD symptoms following combat exposure.[25, 26] We extend this previous work in several ways.”
Admon, R., Leykin, D., Lubin, G., Engert, V., Andrews, J., Pruessner, J., & Hendler, T. (2013) · Human Brain Mapping · doi:10.1002/hbm.22100 · Cited by 138 · see citing works
“In previous fMRI studies using the same study population, we found that such combative military service in the IDF includes exposure to multiple real-life stressful events [Admon et al., 2009; Admon et al., 2012].”
BackgroundSelf-citationNeurobiological basis of stress resilience
Nestler, E. J., & Russo, S. J. (2024) · Neuron · doi:10.1016/j.neuron.2024.05.001 · Cited by 137 · see citing works
van Zuiden, M., Kavelaars, A., Geuze, E., Olff, M., & Heijnen, C. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.015 · Cited by 125 · see citing works
The potential of infant fMRI research and the study of early life stress as a promising exemplar
Graham, A. M., Pfeifer, J. H., Fisher, P. A., Lin, W., Gao, W., & Fair, D. A. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.09.005 · Cited by 114 · see citing works
“Additional ork suggests that greater preexisting amygdala reactivty (prior to deployment) in combination with decreased ucleus accumbens activity over the course of deployent is a particularly strong predictor of increases in stress ymptomatology (Admon et al., 2012).”
Ahmed-Leitao, F., Spies, G., van den Heuvel, L. L., & Seedat, S. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.09.008 · Cited by 120 · see citing works
Koch, K., Reeß, T. J., Rus, O. G., Zimmer, C., & Zaudig, M. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.03.006 · Cited by 113 · see citing works
“…reported association between white matter alterations and degree of obsessive or compulsive symptoms (mostly, Y-BOCS total score, see e.g., Admon et al., 2013; Garibotto et al., 2010; Ha et al., 2009; Li et al., 2011; Szeszko et al., 2005) shows that some of the structural alterations…”
BackgroundNeural contributors to trauma resilience: a review of longitudinal neuroimaging studies
Roeckner, A. R., Oliver, K. I., Lebois, L. A. M., van Rooij, S. J. H., & Stevens, J. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01633-y · Cited by 103 · see citing works
Adolescent Depression: Stress and Reward Dysfunction
Auerbach, R. P., Admon, R., & Pizzagalli, D. A. (2014) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000034 · Cited by 104 · see citing works
“[2013]).(29) (C) Among healthy orphic loci predicted 10.”
An affective neuroscience model of boosting resilience in adults
Tabibnia, G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.005 · Cited by 109 · see citing works
Functional and structural neural indices of risk aversion in obsessive-compulsive disorder (OCD)
Admon, R., Bleich-Cohen, M., Weizmant, R., Poyurovsky, M., Faragian, S., & Hendler, T. (2012) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2012.02.002 · Cited by 100 · see citing works
“Prior work from our laboratory has already shown that these exact intervals evoke selective responses in the amygdala and the striatal nucleus accumbens (Nacc), respectively (Kahn et al., 2002; Assaf et al., 2009; Admon et al., 2012); findings that correspond to the notion that these areas are central nodes within the…”
BackgroundResultSelf-citationToward understanding the impact of trauma on the early developing human brain
Thomason, M. E., & Marusak, H. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.022 · Cited by 101 · see citing works
“with reduced PTSD symptomology in combat-exposed soldiers (Admon et al., 2013).”
BackgroundResultNikolova, Y. S., Knodt, A. R., Radtke, S. R., & Hariri, A. R. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.85 · Cited by 95 · see citing works
The Role of Chronic Stress in Anxious Depression
Ross, R. A., Foster, S. L., & Ionescu, D. F. (2017) · Chronic Stress · doi:10.1177/2470547016689472 · Cited by 92 · see citing works
“Towards this end, one experiment prospectively studied healthy volunteers (n1⁄4 24) before and after active military deployment, in order to assess the effects of chronic war stress towards the development of anxiety.(39) Soldiers completed an interactive game that consisted of risky and rewarding behaviors pre- and p…”
BackgroundMentalizing and motivation neural function during social interactions in autism spectrum disorders
Assaf, M., Hyatt, C. J., Wong, C. G., Johnson, M. R., Schultz, R. T., Hendler, T., & Pearlson, G. D. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.09.005 · Cited by 86 · see citing works
“…SPM using the ‘Ready’, ‘Anticipation of Outcome’ and ‘Response to Outcome’ intervals as regressors (separately for Human and Computer runs) while the ‘Decision-making’ interval was not modeled to be consistent with previous publications (Admon et al., 2013; Assaf et al., 2009; Kahn et al., 2002).”
BackgroundMethodResultInfluentialSelf-citationEnman, N. M., Arthur, K., Ward, S. J., Perrine, S. A., & Unterwald, E. M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.024 · Cited by 85 · see citing works
“For instance, increased amygdalar reactivity in response to risk occurs concurrently with reduced activity of the nucleus accumbens in response to reward (17).”
Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression
Admon, R., Holsen, L. M., Aizley, H. G., Remington, A., Whitfield, S., Goldstein, J. M., & Pizzagalli, D. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.019 · Cited by 76 · see citing works
“Finally, recent fMRI studies demonstrated reduced reward-related striatal activation in healthy individuals after acute laboratory stress (84,85) and after prolonged combat stress (86), with the latter also linking reward-related striatal blunting with greater severity of depressive symptoms (86).”
BackgroundSelf-citationKaldewaij, R., Koch, S. B. J., Hashemi, M. M., Zhang, W., Klumpers, F., & Karin Roelofs, A. (2021) · Nature Human Behaviour · doi:10.1038/s41562-021-01055-2 · Cited by 76 · see citing works
Stevens, J. S., van Rooij, S. J. H., & Jovanović, T. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_38 · Cited by 73 · see citing works
“Amygdala hyper-reactivity is observed in patients with chronic PTSD [25–28], and, more importantly, amygdala reactivity prior to trauma exposure may predict later PTSD severity [29, 30].”
BackgroundBellis, M. D. D., Wang, L., Bergman, S. R., Yaxley, R. H., Hooper, S. R., & Huettel, S. A. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.05.020 · Cited by 71 · see citing works
Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
Stevens, J. S., Harnett, N. G., Lebois, L. A. M., van Rooij, S. J. H., Ely, T. D., Roeckner, A. R., Vincent, N., Beaudoin, F. L., An, X., Zeng, D., et al. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2021.20101526 · Cited by 70 · see citing works
“This was partly contrary to previous findings showing that lower NAcc reward response predicted subsequent PTSD (16).”
Kujawa, A., Klein, D. N., Pegg, S. L., & Weinberg, A. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100791 · Cited by 61 · see citing works
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv116 · Cited by 62 · see citing works
“…reactivity both pre- and early post-trauma has additionally been associated with greater subsequent PTSD symptom severity (Admon et al., 2009; Admon et al., 2012; deRoon-Cassini et al., 2014; McLaughlin et al., 2014), our observation of increased amygdala reactivity to fearful faces after OT…”
InfluentialTowards Solving the Riddle of Forgetting in Functional Amnesia: Recent Advances and Current Opinions
Staniloiu, A., & Markowitsch, H. J. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00403 · Cited by 61 · see citing works
Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD
Ney, L. J., Akhurst, J., Bruno, R., Laing, P. A. F., Matthews, A. J., & Felmingham, K. L. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110118 · Cited by 61 · see citing works
Frijling, J. L., van Zuiden, M., Koch, S. B., Nawijn, L., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Bakker, F. C., Denys, D., et al. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-92 · Cited by 59 · see citing works
“Developing interventions that target vulnerability factors associated with PTSD development is a promising way to explore new early treatment strategies for prevention [17-19] An increased risk of PTSD development is associated with pre-existing dysregulations of (para) sympathetic [17,18] and hypothalamic-pituitary-a…”
BackgroundNawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.020 · Cited by 59 · see citing works
Szeszko, P. R., & Yehuda, R. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.02.005 · Cited by 58 · see citing works
Building Resilience: The Stress Response as a Driving Force for Neuroplasticity and Adaptation
Hermans, E. J., Hendler, T., & Kalisch, R. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.10.016 · Cited by 60 · see citing works
Self-citationThe Role of BDNF-TrkB Signaling in the Pathogenesis of PTSD
Neumeister, A. (2013) · Journal of Depression & Anxiety · doi:10.4172/2167-1044.s4-006 · Cited by 55 · see citing works
“In two prospective studies of military personnel, increased activity in the amygdala in response to emotional stimuli was associated with a greater vulnerability to developing PTSD symptoms [24,61].”
BackgroundRamikie, T. S., & Ressler, K. J. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/kressler · Cited by 53 · see citing works
Hinojosa, C. A., George, G. C., & Ben‐Zion, Z. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02558-w · Cited by 60 · see citing works
“…same research group, the authors found that greater amygdala activation in response to risk anticipation at pre-and post-trauma was related to more PTSD symptoms post-trauma [132] and reduced nucleus accumbens activation to reward post-trauma was related to greater PTSD symptoms post-trauma [132].”
BackgroundStriatal Dopamine Release and Genetic Variation of the Serotonin 2C Receptor in Humans
Mickey, B. J., Sanford, B., Love, T., Shen, P., Hodgkinson, C. A., Stohler, C. S., Goldman, D. A., & Zubieta, J.-K. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1260-12.2012 · Cited by 47 · see citing works
Distinct Processing of Aversive Experience in Amygdala Subregions
Michely, J., Rigoli, F., Rutledge, R. B., Hauser, T. U., & Dolan, R. J. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.07.008 · Cited by 46 · see citing works
“This finding demonstrates that trait-anxious indivi uals display a failure to regulate BLA activity adequately in response to objectively different threat levels, supporting the notion that anxiety is associated with elevated and u ifferentiated amygdala activity, potentially due to a failure to adequately modulate it…”
BackgroundReward processing and future life stress: Stress generation pathway to depression.
Mackin, D. M., Kotov, R., Perlman, G., Nelson, B. D., Goldstein, B. L., Hajcak, G., & Klein, D. N. (2019) · Journal of Abnormal Psychology · doi:10.1037/abn0000427 · Cited by 43 · see citing works
“Life stress, including early childhood maltreatment, disrupts neural processing of reward (Admon et al., 2013; Auerbach, Admon, & Pizzagalli, 2014; Casement et al., 2014; McCrory, Gerin, & Viding, 2017; Novick et al., 2018), and these neurodevelopmental changes in reward processing influence later…”
BackgroundStress-resilience impacts psychological wellbeing as evidenced by brain–gut microbiome interactions
An, E., Delgadillo, D. R., Yang, J., Agarwal, R., Labus, J. S., Pawar, S., Leitman, M., Kilpatrick, L. A., Bhatt, R. R., Vora, P. P., et al. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00266-6 · Cited by 45 · see citing works
“Lower activity within the salience network 53 , but increased connectivity within the sensorimotor network 54,55 as well as greater responses in reward circuits (basal ganglia) 56 have been linked to resilience.”
Koch, K., Wagner, G., Schachtzabel, C., Schultz, C. C., Güllmar, D., Reichenbach, J. R., Sauer, H., Zimmer, C., & Schlösser, R. G. M. (2014) · Human Brain Mapping · doi:10.1002/hbm.22284 · Cited by 42 · see citing works
“Amongst these, the nucleus accumbens (NAcc) constituting a major portion of the ventral striatum and receiving direct mesolimbic projections from the ventral tegmental area (VTA) has been proposed as the key brain structure in the regulation of reward-appetitive behavior [Admon et al., 2013; Camara et al., 2009; Cohen…”
BackgroundAnhedonia in Posttraumatic Stress Disorder: Prevalence, Phenotypes, and Neural Circuitry
Vinograd, M., Stout, D. M., & Risbrough, V. B. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_292 · Cited by 39 · see citing works
Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder?
Risbrough, V. B., Glynn, L. M., Davis, E. P., Sandman, C. A., Obenaus, A., Stern, H. S., Keator, D. B., Yassa, M. A., Baram, T. Z., & Baker, D. G. (2018) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_51 · Cited by 37 · see citing works
Hyatt, C. J., Assaf, M., Muska, C. E., Rosen, R. I., Thomas, A. D., Johnson, M. R., Hylton, J. L., Andrews, M. M., Reynolds, B. A., Krystal, J. H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034917 · Cited by 37 · see citing works
“The Domino fMRI task was originally introduced to examine the role of the amygdala in signaling prospective negative outcomes during risk-taking [39,40], but has also been shown to strongly activate the reward system, particularly the ventral striatum, as a result of gains during gameplay [40,41].”
Self-citationAltered reward processing following an acute social stressor in adolescents
Lincoln, S. H., Pisoni, A., Bondy, E., Kumar, P., Singleton, P., Hajcak, G., Pizzagalli, D. A., & Auerbach, R. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0209361 · Cited by 35 · see citing works
“, ventral striatum) activation during reward receipt [21].”
BackgroundRab, S. L., & Admon, R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.007 · Cited by 34 · see citing works
Self-citationPichon, S., Lombard, E., Eryilmaz, H., & Vuilleumier, P. O. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu044 · Cited by 35 · see citing works
Sheynin, S., Wolf, L., Ben‐Zion, Z., Sheynin, J., Balter, S. R., Keynan, J. N., Admon, R., Shalev, A. Y., Hendler, T., & Liberzon, I. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118242 · Cited by 34 · see citing works
“The rest of the connectivities are related to the 477 nature of this dynamic task, as was shown in previous work [1, 84, 6].”
InfluentialSelf-citationReward Processing and Circuit Dysregulation in Posttraumatic Stress Disorder
Lokshina, Y., Nickelsen, T., & Liberzon, I. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.559401 · Cited by 35 · see citing works
“Reward Outcome Several studies have indicated that PTSD patients, compared to trauma-exposed controls, exhibit decreased ventral striatal and decreased medial prefrontal cortex (mPFC) activation to reward (relative to loss) (10, 90).”
BackgroundLong-Term Effects of Acute Stress on the Prefrontal-Limbic System in the Healthy Adult
Li, Y., Hou, X., Wei, D., Du, X., Zhang, Q., Liu, G., & Qiu, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168315 · Cited by 34 · see citing works
Neural indicators of interpersonal anger as cause and consequence of combat training stress symptoms
Gilam, G., Lin, T., Fruchter, E., & Hendler, T. (2017) · Psychological Medicine · doi:10.1017/s0033291716003354 · Cited by 31 · see citing works
“We recently proposed a model which aimed to disentangle predisposing from acquired neural abnormalities of PTSD (Admon et al. 2013b), highlighting hyperactivity of the amygdala and dorsal anterior cingulate cortex as predisposing factors and vmPFC– hippocampus hypoconnectivity as an acquired…”
BackgroundInfluentialSelf-citationEthridge, P., Ali, N., Racine, S. E., Pruessner, J. C., & Weinberg, A. (2020) · Clinical Psychological Science · doi:10.1177/2167702620917463 · Cited by 32 · see citing works
A Possible Role of Anhedonia as Common Substrate for Depression and Anxiety
Grillo, L. (2016) · Depression Research and Treatment · doi:10.1155/2016/1598130 · Cited by 31 · see citing works
“depression and anxiety are both part of the same continuum of problems [25, 26] and that they have a common substrate [27–29] that some authors suggest might be anhedonia [22].”
BackgroundThe Role of Mesolimbic Circuitry in Buffering Election-Related Distress
Tashjian, S. M., & Galván, A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2470-17.2018 · Cited by 29 · see citing works
Ben‐Zion, Z., Fine, N. B., Keynan, J. N., Admon, R., Halpern, P., Liberzon, I., Hendler, T., & Shalev, A. Y. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1683941 · Cited by 30 · see citing works
Self-citationBen‐Zion, Z., Shany, O., Admon, R., Keynan, J. N., Avisdris, N., Balter, S. R., Shalev, A. Y., Liberzon, I., & Hendler, T. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.09.001 · Cited by 28 · see citing works
Self-citationFarber, M. J., Kim, M. J., Knodt, A. R., & Hariri, A. R. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100711 · Cited by 26 · see citing works
Rowland, J. A., Stapleton-Kotloski, J. R., Alberto, G. E., Rawley, J. A., Kotloski, R. J., Taber, K. H., & Godwin, D. W. (2016) · Brain Connectivity · doi:10.1089/brain.2015.0406 · Cited by 25 · see citing works
“…deployment or combat exposure demonstrated changes in brain structure, function, and functional connectivity following war zone deployment (Admon et al., 2009, 2013a,b; van Wingen et al., 2011, 2012), although not directly due to the development of PTSD. Exploratory analyses to evaluate…”
BackgroundKehyayan, A., Wright, P., Marks, J., Matura, J.-M., Axmacher, N., Herpertz, S., & Kessler, H. (2023) · European Journal of Psychotraumatology · doi:10.1080/20008066.2023.2172258 · Cited by 23 · see citing works
Norbury, A., Seeley, S. H., Pérez-Rodríguez, M. M., & Feder, A. (2023) · Psychological Medicine · doi:10.1017/s0033291723001162 · Cited by 22 · see citing works
“…combat-exposed paramedics, decreased reward response in the nucleus accumbens post-, but not pre-exposure, was found to be related to self-18 reported PTSD symptoms – suggesting that preserved reward responses may be a marker of resilience, rather than a prospective indicator (Admon et al., 2013).”
BackgroundBoukezzi, S. C., Baunez, C., Rousseau, P., Warrot, D., Silva, C., Guyon, V., Zendjidjian, X. Y., Nicolas, F., Guedj, É., Nazarian, B., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102073 · Cited by 22 · see citing works
“As compared with healthy controls, PTSD patients showed lower activation in key components of the reward system when obtaining rewards, namely the NAcc, the ventral and dorsal striatum and the mPFC (Elman et al., 2009; Admon et al., 2013).”
Lijffijt, M., Green, C. E., Balderston, N. L., Iqbal, T., Atkinson, M. E., Vo‐Le, B., Vo-Le, B., O’Brien, B., Grillon, C., Swann, A. C., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00846 · Cited by 20 · see citing works
“In humans, enhanced reactivity of the amygdala could predispose to development of PTSD symptoms (51, 52) and is associated with less resilience to stressors of everyday life (53).”
BackgroundParadoxical associations between familial affective responsiveness, stress, and amygdala reactivity.
Farber, M. J., Romer, A. L., Kim, M. J., Knodt, A. R., Elsayed, N. M., Williamson, D. E., & Hariri, A. R. (2018) · Emotion · doi:10.1037/emo0000467 · Cited by 19 · see citing works
“…et al., 2015; Pechtel et al., 2014; Sheridan et al., 2012; Tottenham, 2012; Tottenham et al., 2010) but also represents a biomarker of future risk for stress-related depression and anxiety (Admon et al., 2013; Etkin & Wager, 2007; Schlund & Cataldo, 2010; Swartz, Knodt, Radtke, & Hariri, 2015).”
Scheeringa, M. S. (2020) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1864 · Cited by 19 · see citing works
Freeman, C. R., Panier, L. Y. X., Schaffer, J., & Weinberg, A. (2022) · Psychophysiology · doi:10.1111/psyp.14206 · Cited by 18 · see citing works
Can Understanding Reward Help Illuminate Anhedonia?
Kaya, S., & McCabe, C. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-00186-1 · Cited by 16 · see citing works
Simon, L., Levi, S., Shapira, S., & Admon, R. (2024) · SLEEP · doi:10.1093/sleep/zsae183 · Cited by 17 · see citing works
Self-citationProspective examination of pre-trauma anhedonia as a risk factor for post-traumatic stress symptoms
Acheson, D. T., Vinograd, M., Nievergelt, C. M., Yurgil, K. A., Moore, T. M., Risbrough, V. B., & Baker, D. G. (2022) · European Journal of Psychotraumatology · doi:10.1080/20008198.2021.2015949 · Cited by 17 · see citing works
“ventral striatum BOLD response) are also associated with more severe post-traumatic stress (PTS) symptoms or PTSD diagnosis (Admon et al., 2013; Admon, Milad, & Hendler, 2013; Elman et al., 2009; Sailer et al., 2008).”
BackgroundClockViz: Designing Public Visualization for Coping with Collective Stress in Teamwork
Xue, M., Liang, R.-H., Hu, J., & Feijs, L. M. G. (2017) · InTech eBooks · doi:10.5772/intechopen.71220 · Cited by 16 · see citing works
“can be created and adjusted through complete difficult tasks or challenging games, such as memory card game [13], domino game [14], soccer game [15], and first-person shooter game [16], which validity and practicability have been proven in the previous research [17].”
BackgroundGhaffarzadegan, R., Akhondzadeh, S., Nikasa, Z., Hajizamani, S., Mehrabanifar, S., Cheraghi, I., & Vaseghi, S. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04242-5 · Cited by 16 · see citing works
“In the NAc, research on soldiers found diminished coping in individuals with decreased BDNF-TrkB signal - ing and activity in the NAc, mediated by a combination of genetic vulnerability and traumatic experience [ 76 ].”
Dell’Acqua, C., Moretta, T., Bò, E. D., Benvenuti, S. M., & Palomba, D. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.02.027 · Cited by 16 · see citing works
de Voogd, L. D., Hashemi, M. M., Zhang, W., Kaldewaij, R., Koch, S. B. J., van Ast, V. A., Klumpers, F., & Karin Roelofs, A. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.02.894 · Cited by 15 · see citing works
Martin-Söelch, C., Guillod, M., Gaillard, C., Recabarren, R. E., Federspiel, A., Mueller‐Pfeiffer, C., Homan, P., Hasler, G., Schoebi, D., Horsch, A., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.563475 · Cited by 14 · see citing works
“It has been hypothesized that an imbalance between stress and reward reactivity could be a predictor for the development of psychopathology in general (39, 40) and for MDD in particular (9).”
BackgroundWarhaftig, G., Zifman, N., Sokolik, C. M., Massart, R., Gabay, O., Sapozhnikov, D. M., Vaisheva, F., Lichtenstein, Y., Confortti, N., Ahdoot, H. L., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01178-y · Cited by 16 · see citing works
Thaler, A., Gonen, T., Mirelman, A., Helmich, R. C. G., Gurevich, T., Orr‐Urtreger, A., Bloem, B. R., Giladi, N., & Hendler, T. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9920-2 · Cited by 15 · see citing works
Self-citationFrom Animal Model to Human Brain Networking: Dynamic Causal Modeling of Motivational Systems
Gonen, T., Admon, R., Podlipsky, I., & Hendler, T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6188-11.2012 · Cited by 16 · see citing works
“To achieve this aim, we used an interactive game that included distinct expressions of relevant motivational states and that has been previously shown to elicit increased amygdala response to punishment and NAcc response to reward (Kahn et al., 2002; Assaf et al., 2009; Admon et al., 2012).”
MethodSelf-citationHinojosa, C. A., VanElzakker, M. B., Hughes, K. C., Offringa, R., Sangermano, L., Spaulding, I. G., Staples-Bradley, L. K., Whitman, E. T., Lasko, N. B., Rauch, S. L., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.049 · Cited by 13 · see citing works
Bennett, M. M., Davis, K. E., & Fitzgerald, J. M. (2023) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2023.05.007 · Cited by 15 · see citing works
Nahum, M., Sinvani, R.-T., Afek, A., Ben-Avraham, R., Jordan, J. T., Ben‐Shachar, M. S., Yehuda, A. B., Cohen, N., Davidov, A., & Gilboa, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-40242-1 · Cited by 14 · see citing works
Pegg, S. L., & Kujawa, A. (2023) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-023-01143-y · Cited by 14 · see citing works
“…literature, exposure to stressors is associated with altered response in regions of the brain associated with reward processing, including the striatum (Admon et al., 2013; Born et al., 2010; Kruse et al., 2018; Kumar et al., 2014; Lincoln et al., 2019; Porcelli et al., 2012; Wei et al., 2013).”
InfluentialDefining the r factor for post-trauma resilience and its neural predictors
van Rooij, S. J. H., Santos, J. L., Hinojosa, C. A., Ely, T. D., Harnett, N. G., Murty, V. P., Lebois, L. A. M., Jovanović, T., House, S. L., Bruce, S. E., et al. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00242-0 · Cited by 16 · see citing works
“Few studies in the early aftermath of trauma have investigated rewardrelated processing 52–54 , and the current study shows the importance of studying neurobiological mechanisms of reward processing in addition to threat and inhibi tion.”
Iadipaolo, A. S., Marusak, H. A., Sala‐Hamrick, K., Crespo, L. M., Thomason, M. E., & Rabinak, C. A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.039 · Cited by 14 · see citing works
“Links among BAS sensitivity, stress exposure, and onset of psychopathology are established in prior prospective studies [60], suggesting that potential mediating effects of BAS sensitivity, and/or associated DMN-sgACC rsFC may emerge over time, or later in life.”
BackgroundNeurophysiological Assessment of Anhedonia in Depression and Schizophrenia
Foti, D., Novak, K. D., Hill, K. E., & Oumeziane, B. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813693-5.00013-7 · Cited by 14 · see citing works
Eckstrand, K., Forbes, E. E., Bertocci, M. A., Chase, H. W., Greenberg, T., Lockovich, J., Stiffler, R., Aslam, H. A., Graur, S., Bebko, G. M., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.11.017 · Cited by 14 · see citing works
Eckstrand, K., Silk, J. S., Nance, M., Wallace, M. L., Buckley, N., Lindenmuth, M., Flores, L. E., Alarcón, G., Quevedo, K. M., Phillips, M. L., et al. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.08.009 · Cited by 14 · see citing works
Suarez‐Jimenez, B., Lazarov, A., Zhu, X., Pine, D. S., Bar‐Haim, Y., & Neria, Y. (2022) · Psychological Medicine · doi:10.1017/s003329172200157x · Cited by 13 · see citing works
“This exploratory finding corresponds with approaches viewing PTSD as an imbalance of the negative (fear-related) and positive (reward-related) valence systems, with the former attaining precedence over the latter (Admon et al., 2013; Stein & Paulus, 2009).”
- Authors
- Admon, R., Lubin, G., Rosenblatt, J. D., Stern, O., Kahn, I., Assaf, M., & Hendler, T.
- Affiliations
- Tel Aviv University (IL)
- Israel Defense Forces Medical Corps (IL)
- Technion – Israel Institute of Technology (IL)
- Hartford Hospital (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-30
- Volume
- 23
- Issue
- 1
- Pages
- 28-35
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2103498835
- Cited by
- 143
- References
- 41
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 15 · 2019: 13 · 2018: 6 · 2017: 10 · 2016: 14 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 8
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- stress vulnerability, risk sensitivity, reward sensitivity, amygdala, nucleus accumbens, post-traumatic stress disorder, military service, military personnel, emotional reactivity, stress exposure
- MeSH terms
- Adolescent, Cerebral Cortex, Cognitive Dissonance, Decision Making, Disease Susceptibility, Female, Games, Experimental, Humans, Male, Reward, Risk-Taking, Stress Disorders, Post-Traumatic, Stress, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
