Brain tissue compartment density estimated using diffusion‐weighted MRI yields tissue parameters consistent with histology
Open accessAbstract
We examined whether quantitative density measures of cerebral tissue consistent with histology can be obtained from diffusion magnetic resonance imaging (MRI). By incorporating prior knowledge of myelin and cell membrane densities, absolute tissue density values were estimated from relative intracellular and intraneurite density values obtained from diffusion MRI. The NODDI (neurite orientation distribution and density imaging) technique, which can be applied clinically, was used. Myelin density estimates were compared with the results of electron and light microscopy in ex vivo mouse brain and with published density estimates in a healthy human brain. In ex vivo mouse brain, estimated myelin densities in different subregions of the mouse corpus callosum were almost identical to values obtained from electron microscopy (diffusion MRI: 42 ± 6%, 36 ± 4%, and 43 ± 5%; electron microscopy: 41 ± 10%, 36 ± 8%, and 44 ± 12% in genu, body and splenium, respectively). In the human brain, good agreement was observed between estimated fiber density measurements and previously reported values based on electron microscopy. Estimated density values were unaffected by crossing fibers. Hum Brain Mapp 36:3687–3702, 2015 . © 2015 Wiley Periodicals, Inc.
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There is a significant correlation between myelin density estimated by absolute tissue density from NODDI (ABTIN) and myelin density obtained from electron microscopy in the mouse corpus callosum.
“There is significant correlation between myelin density estimated by absolute tissue density from NODDI (ABTIN) and myelin density obtained from electron microscopy in the mouse corpus callosum (Sepehrband et al. 2015).”
From Neurite orientation dispersion and density imaging of mouse brain microstructure (2019) · cites this paper as Sepehrband et al. 2015
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“MD represents direction-insensitive measure of the total fiber membrane density [21]) and, as a result, remained relatively uniform across the entire white matter in normal brain tissue (see”
Background
- Authors
- Sepehrband, F., Clark, K. A., Ullmann, J. F. P., Kurniawan, N. D., Leanage, G., Reutens, D. C., & Yang, Z.
- Affiliations
- The University of Queensland (AU)
- University of Southern California (US)
- Corresponding author
- Sepehrband, Farshid
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2015-06-11
- Volume
- 36
- Issue
- 9
- Pages
- 3687-3702
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC4545675
- OpenAlex
- W1899759537
- Cited by
- 143
- References
- 11
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 10 · 2023: 15 · 2022: 11 · 2021: 19 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 17 · 2016: 8 · 2015: 3 · 2013: 1
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Queensland Centennial (UQCent) and International Postgraduate Research Scholarship (IPRS) (F.S.)
- Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) (K99/R00-HD065832 (K.C.))
- National Institutes of Health (P41-EB015922, R01MH092301, and R01MH094343)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Keywords
- diffusion MRI, NODDI, myelin density, fiber density, corpus callosum, mouse brain, human brain, histopathological confirmation, electron microscopy, crossing fibers
- MeSH terms
- Adult, Animals, Corpus Callosum, Humans, Male, Mice, Inbred C57BL, Microscopy, Electron, Models, Theoretical, Myelin Sheath, Anisotropy, Diffusion Magnetic Resonance Imaging, Mice, White Matter
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