Neuroticism and conscientiousness respectively constrain and facilitate short‐term plasticity within the working memory neural network
Open accessAbstract
Individual differences in cognitive efficiency, particularly in relation to working memory (WM), have been associated both with personality dimensions that reflect enduring regularities in brain configuration, and with short‐term neural plasticity, that reflects task‐related changes in brain connectivity. To elucidate the relationship of these two divergent mechanisms, we tested the hypothesis that personality dimensions, which reflect enduring aspects of brain configuration, inform about the neurobiological framework within which short‐term, task‐related plasticity, as measured by effective connectivity, can be facilitated or constrained. As WM consistently engages the dorsolateral prefrontal (DLPFC), parietal (PAR), and anterior cingulate cortex (ACC), we specified a WM network model with bidirectional, ipsilateral, and contralateral connections between these regions from a functional magnetic resonance imaging dataset obtained from 40 healthy adults while performing the 3‐back WM task. Task‐related effective connectivity changes within this network were estimated using Dynamic Causal Modelling. Personality was evaluated along the major dimensions of Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientiousness. Only two dimensions were relevant to task‐dependent effective connectivity. Neuroticism and Conscientiousness respectively constrained and facilitated neuroplastic responses within the WM network. These results suggest individual differences in cognitive efficiency arise from the interplay between enduring and short‐term plasticity in brain configuration. Hum Brain Mapp 36:4158–4163, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
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Personality trait modulates or is linked to objective measures, particularly WM.
“studies showed that personality trait modulates or is linked to objective measures (i.e., cognitive ability), particularly to WM”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Dima et al., 2015
The association of traits in the Big Five model and WM showed mixed results.
“although the association of traits in the ‘Big Five’ model and WM showed mixed results (Dima et al., 2015; Waris et al., 2018).”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Dima et al., 2015
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“, 2016; Schmidt‐Hansen & Honey, 2009), although the association of traits in the ‘Big Five’ model and WM showed mixed results (Dima et al., 2015; Waris et al., 2018).”
BackgroundResult
- Authors
- Dima, D., Friston, K. J., Stephan, K. E., & Frangou, S.
- Affiliations
- King's College London (GB)
- Wellcome Centre for Human Neuroimaging (GB)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Frangou, Sophia
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2015-07-20
- Volume
- 36
- Issue
- 10
- Pages
- 4158-4163
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC4863074
- OpenAlex
- W2162761992
- Cited by
- 50
- References
- 5
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 7
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Human Brain Mapping (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- City Research Online (City University London) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Wellcome Trust (091593, 088130)
- National Institute of Mental Health (R01MH104284)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- working memory, neuroticism, conscientiousness, effective connectivity, personality factors, dorsolateral prefrontal cortex, parietal cortex, anterior cingulate cortex, 3-back task, dynamic causal modeling, brain network models
- MeSH terms
- Neuroticism, Adult, Anxiety Disorders, Brain Mapping, Cerebral Cortex, Extraversion, Psychological, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Models, Neurological, Nerve Net, Neuronal Plasticity, Personality, Personality Tests, Psychomotor Performance, Reaction Time
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