The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Structural and functional connectivity of the precuneus and thalamus to the default mode network: Precuneus-Thalamus Connectivity to the DMN
Open accessAbstract
Neuroimaging studies have identified functional interactions between the thalamus, precuneus, and default mode network (DMN) in studies of consciousness. However, less is known about the structural connectivity of the precuneus and thalamus to regions within the DMN. We used diffusion tensor imaging (DTI) to parcellate the precuneus and thalamus based on their probabilistic white matter connectivity to each other and DMN regions of interest (ROIs) in 37 healthy subjects from the Human Connectome Database. We further assessed resting-state functional connectivity (RSFC) among the precuneus, thalamus, and DMN ROIs. The precuneus was found to have the greatest structural connectivity with the thalamus, where connection fractional anisotropy (FA) increased with age. The precuneus also showed significant structural connectivity to the hippocampus and middle pre-frontal cortex, but minimal connectivity to the angular gyrus and midcingulate cortex. In contrast, the precuneus exhibited significant RSFC with the thalamus and the strongest RSFC with the AG. Significant symmetrical structural connectivity was found between the thalamus and hippocampus, mPFC, sFG, and precuneus that followed known thalamocortical pathways, while thalamic RSFC was strongest with the precuneus and hippocampus. Overall, these findings reveal high levels of structural and functional connectivity linking the thalamus, precuneus, and DMN. Differences between structural and functional connectivity (such as between the precuneus and AG) may be interpreted to reflect dynamic shifts in RSFC for cortical hub-regions involved with consciousness, but could also reflect the limitations of DTI to detect superficial white matter tracts that connect cortico-cortical regions. Hum Brain Mapp 38:938-956, 2017. © 2016 Wiley Periodicals, Inc.
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Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Behrens, T. E. J., Johansen-Berg, H., Woolrich, M. W., Smith, S. M., Wheeler-Kingshott, C. A. M., Boulby, P. A., Barker, G. J., Sillery, E. L., Sheehan, K., Ciccarelli, O., et al. (2003) · Nature Neuroscience · doi:10.1038/nn1075 · Cited by 2,330
Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network
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“Connectivity of the DMN is reduced in proportion to a patient’s level of impairment [Vanhaudenhuyse et al., 2010] and decreases in glucose metabolism have been observed in key regions of the DMN (including the precuneus) during states of impaired consciousness [Fridman et al., 2014; Garc ıa-Panach…”
BackgroundRecovery of consciousness after brain injury: a mesocircuit hypothesis
Schiff, N. D. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.002 · Cited by 733
Age-related alterations in default mode network: Impact on working memory performance
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Measuring macroscopic brain connections in vivo
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Cited by
Alves, P. N., Foulon, C., Karolis, V., Bzdok, D., Margulies, D. S., Volle, E., & Thiebaut de Schotten, M. (2019) · Communications Biology · doi:10.1038/s42003-019-0611-3 · Cited by 357
Bertero, A., Liska, A., Pagani, M., Parolisi, R., Masferrer, M. E., Gritti, M., Pedrazzoli, M., Galbusera, A., Sarica, A., Cerasa, A., et al. (2018) · Brain · doi:10.1093/brain/awy111 · Cited by 120
Zarkali, A., McColgan, P., Leyland, L. A., Lees, A. J., & Weil, R. S. (2022) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-326630 · Cited by 32
Metadata
- Authors
- Cunningham, S. I., Tomasi, D., & Volkow, N. D.
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2016-10-14
- Volume
- 38
- Issue
- 2
- Pages
- 938-956
- ISSN
- 1065-9471 (ISSN-L)
- OpenAlex
- W2557089988
- Cited by
- 212
- References
- 14
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- green
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