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Cited by 357Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsMind wandering and attention

An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

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Alves, Pedro Nascimento, Foulon, Chris, Karolis, Vyacheslav, Bzdok, Danilo, Margulies, Daniel S., Volle, Emmanuelle, Thiebaut de Schotten, Michel·2019·Communications Biology
DOI 10.1038/s42003-019-0611-3PMC PMC6787009
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Abstract

The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing research into the DMN has taken a corticocentric approach. Despite its resemblance with the unitary model of the limbic system, the contribution of subcortical structures to the DMN may be underappreciated. Here, we propose a more comprehensive neuroanatomical model of the DMN including subcortical structures such as the basal forebrain, cholinergic nuclei, anterior and mediodorsal thalamic nuclei. Additionally, tractography of diffusion-weighted imaging was employed to explore the structural connectivity, which revealed that the thalamus and basal forebrain are of central importance for the functioning of the DMN. The contribution of these neurochemically diverse brain nuclei reconciles previous neuroimaging with neuropathological findings in diseased brains and offers the potential for identifying a conserved homologue of the DMN in other mammalian species.

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  • The DMN is a collection of distributed and interconnected brain regions that are typically suppressed when an individual is focused on external stimuli.

    “The DMN is a collection of distributed and interconnected brain regions 3 (Figure 1) that are typically suppressed when an individual is focused on external stimuli”

    From 20 years of the default mode network: A review and synthesis. (2023) · cites this paper as [3]

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Authors
Alves, P. N., Foulon, C., Karolis, V., Bzdok, D., Margulies, D. S., Volle, E., & Thiebaut de Schotten, M.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Institut national de recherche en sciences et technologies du numérique (FR)
Corresponding author
Alves, Pedro Nascimento
ORCID
Venue
Communications Biology
Publisher
Springer Science and Business Media LLC
Published
2019-10-10
Volume
2
Issue
1
Pages
370-370
ISSN
2399-3642 (ISSN-L)
DOI
10.1038/s42003-019-0611-3
PMC
PMC6787009
OpenAlex
W2979923937
Cited by
357
References
181
Citations by year
2026: 25 · 2025: 55 · 2024: 60 · 2023: 69 · 2022: 74 · 2021: 46 · 2020: 27 · 2017: 1
FWCI
21.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Communications Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • HAL Portal Artxiker (Hindustan Aeronautics Limited (India)) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
Funders
  • European Commission (HORIZON2020, ANR-13, 818521)
  • Agence Nationale de la Recherche (ANR-13-JSV4-0001)
  • European Academy of Neurology
  • Santa Casa da Misericórdia de Lisboa
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
Keywords
default mode network, neuroanatomical model, subcortical structures, basal forebrain, cholinergic nuclei, thalamus, anterior thalamic nuclei, structural connectivity, limbic system, neuropathology
MeSH terms
Adult, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Neural Pathways, Imaging, Three-Dimensional, Young Adult, Neuroimaging

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