Enteral glutamine supplementation in surgical patients with head and neck malignancy: A randomized controlled trial
Abstract
Background: Glutamine supplementation is a novel approach to perioperative nutritional management. Methods: This study was a prospective randomized clinical trial of effects of enteral glutamine supplementation in surgical patients with head and neck malignancy in a tertiary center. This study measured the effects of supplementation within 4 weeks of the postoncologic surgical period in relation to fat‐free mass, serum albumin, and quality of life scores. Results: The study population consisted of 44 patients. There was significant difference in serum albumin (p < .001), fat‐free mass (p < .001), and quality of life scores (p < .05) between control and interventional groups. Significant correlation exists between fat‐free mass and quality of life score difference in our study population (p < .05). Conclusion: Enteral glutamine supplementation significantly improves fat‐free mass, serum albumin, and quality of life scores postoperatively and maintenance of lean body mass correlated with improved postoperative outcomes in terms of the patient's quality of life. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1799–1807, 2015
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The efficiency of enteral GLN on infection reduction was also suggested in major trauma.
“The efficiency of enteral GLN on infection reduction was also suggested in major trauma (219).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [219]
Enteral GLN was shown to improve body composition and in particular lean body mass in a group of 44 head and neck cancer patients randomized to receive a GLN supplement (30 g daily) for four weeks.
“Finally, enteral GLN was shown to improve body composition and in particular lean body mass in a group of 44 head and neck cancer patients randomized to receive a GLN supplement (30 g daily) for four weeks [81].”
From ESPEN practical and partially revised guideline: Clinical nutrition in the intensive care unit (2023) · cites this paper as [81]
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ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904 · see citing works
ESPEN practical and partially revised guideline: Clinical nutrition in the intensive care unit
Singer, P., Blaser, A. R., Berger, M. M., Calder, P. C., Casaer, M., Hiesmayr, M., Mayer, K., Montejo-Gonzalez, J. C., Pichard, C., Preiser, J.-C., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.07.011 · Cited by 793 · see citing works
Soares, J. D. P., Howell, S. L., Teixeira, F. J., & Pimentel, G. D. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200218100420 · Cited by 61 · see citing works
- Authors
- Azman, M., Mohd Yunus, M. R., Sulaiman, S., & Syed Omar, S. N.
- Affiliations
- University Kebangsaan Malaysia Medical Centre (MY)
- Department of Otorhinolaryngology Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia
- National University of Malaysia (MY)
- Department of Oral and Maxillofacial Surgery Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia.
- Corresponding author
- Azman, Mawaddah
- ORCID
- Azman, Mawaddah
- Venue
- Head & Neck
- Publisher
- Wiley
- Published
- 2015-06-20
- Volume
- 37
- Issue
- 12
- Pages
- 1799-1807
- ISSN
- 1043-3074 (ISSN-L)
- 1097-0347
- OpenAlex
- W1951744689
- Cited by
- 21
- References
- 0
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 4 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Head & Neck (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universiti Kebangsaan Malaysia Fundamental Grant.
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- glutamine supplementation, enteral nutrition, head and neck cancer, perioperative nutritional management, fat-free mass, serum albumin, quality of life, lean body mass, postoperative outcomes
- MeSH terms
- Administration, Oral, Adult, Aged, Female, Glutamine, Head and Neck Neoplasms, Hospitals, University, Humans, Male, Middle Aged, Prospective Studies, Quality of Life, Serum Albumin, Biomarkers, Body Mass Index, Treatment Outcome, Dietary Supplements, Perioperative Care, Young Adult
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