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The significance of “positive” margins in surgically resected epidermoid carcinomas
Abstract
Sixty‐two patients with epidermoid carcinomas of the head and neck (excluding glottic larynx and skin), in whom surgical‐resection margins were classified as “positive,” were studied to determine the incidence of local recurrence, the subsequent clinical course, and survival. The recurrence rate in this group was compared with that of patients who had “negative” margins. Four histologic findings are classified as positive margins: (1) margin closeness (tumor within 0.5 cm), (2) premalignant change in the margin, (3) in‐situ cancer in the margin, and (4) invasive microscopic cancer at the margin. Patients with these variants showed a significant increase in local recurrence and in mortality when compared to those with negative margins. A review of the literature is presented, and recommendations are made for this clinical setting.
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Cited by
Peters, L. J., Goepfert, H., Ang, K. K., Byers, R. M., Maor, M. H., Guillamondegui, O., Morrison, W. H., Weber, R. S., Garden, A. S., Frankenthaler, R. A., et al. (1993) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(93)90167-t · Cited by 538
Molecular biology of squamous cell carcinoma of the head and neck
Perez-Ordoñez, B., Beauchemin, M., & Jordan, R. C. K. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2003.007641 · Cited by 314
Metadata
- Authors
- Looser, K. G., Shah, J. P., & Strong, E. W.
- Venue
- Head & Neck Surgery
- Publisher
- Wiley
- Published
- 1978-11
- Volume
- 1
- Issue
- 2
- Pages
- 107-111
- ISSN
- 0148-6403 (ISSN-L)
- 1930-2398
- OpenAlex
- W2159390830
- Cited by
- 376
- References
- 0
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The significance of “positive” margins in surgically resected epidermoid carcinomas. https://app.cochat.ai/papers/10.1002/hed.2890010203
- The paper
- Looser, K. G., Shah, J. P., & Strong, E. W. (1978). The significance of “positive” margins in surgically resected epidermoid carcinomas. Head & Neck Surgery. https://doi.org/10.1002/hed.2890010203
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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