Cited by 314Head and Neck Cancer StudiesCancer-related Molecular PathwaysOral Health Pathology and Treatment

Molecular biology of squamous cell carcinoma of the head and neck

Open access
Perez-Ordoñez, B, Beauchemin, M, Jordan, R C K·2006·Journal of Clinical Pathology

Abstract

Squamous cell carcinoma of the head and neck (HNSCC) is a heterogeneous but largely preventable disease with complex molecular abnormalities. It arises from a premalignant progenitor followed by outgrowth of clonal populations associated with cumulative genetic alterations and phenotypic progression to invasive malignancy. These genetic alterations result in inactivation of multiple tumour suppressor genes and activation of proto-oncogenes, including p16 ink4A , p53, cyclin D1, p14 ARF , FHIT , RASSF1A , epidermal growth factor receptor (EGFR), and Rb. Intramucosal migration and clonal expansion of transformed cells with formation of abnormal genetic fields appear to be responsible for local recurrences and development of second primary tumours.

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Integrity signals

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Crossref · 10.1136/jcp.2003.007641

Cites

118 of 118 references verified0 citation errors · 0 not checkable

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  • HPV initiates cervical carcinoma and head and neck squamous carcinoma in part by inactivating RB through E7.

    “human papillomavirus (HPV) is thought to initiate cervical carcinoma and squamous cell carcinoma of the head and neck in part by inactivating RB through expression of the E7 oncoprotein21,22”

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Cites

3 retracted

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Research works printed but not linked: 5

  1. Shahnavaz SA, Regezi JA, Bradley G, et al. p53 gene mutations in sequential oral epithelial dysplasias and squamous cell carcinomas. J Pathol 2000;190:417-22.
  2. Lydiatt WM, Anderson PE, Bazzana T, et al. Molecular support for field cancerization in the head and neck. Cancer 1998;82:1376-80.
  3. van Oijen MG, Leppers Vd Straat FG, Tilanus MG, et al. The origins of multiple squamous cell carcinomas in the aerodigestive tract. Cancer 2000;88:884-93.
  4. van der Toorn PP, Veltman JA, Bot FJ, et al. Mapping of resection margins of oral cancer for p53 overexpression and chromosome instability to detect residual (pre)malignant cells. J Pathol 2001;193:66-72.
  5. Devaraj K, Gillison ML, Wu TC. Development of HPV vaccines for HPV- associated head and neck squamous cell carcinoma. Crit Rev Oral Biol Med 2003;14:345-62. 107

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Authors
Perez-Ordoñez, B., Beauchemin, M., & Jordan, R. C. K.
Affiliations
  • Hôpital du Saint-Sacrement (CA)
  • University of California, San Francisco (US)
Venue
Journal of Clinical Pathology
Publisher
BMJ
Published
2006-04-27
Volume
59
Issue
5
Pages
445-453
ISSN
  • 0021-9746 (ISSN-L)
  • 1472-4146
OpenAlex
W2010703150
Cited by
314
References
118
Citations by year
2026: 3 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 5 · 2020: 5 · 2019: 12 · 2018: 12 · 2017: 16 · 2016: 20 · 2015: 20 · 2014: 23 · 2013: 20 · 2012: 23
FWCI
4.60
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Pathology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
Keywords
head and neck squamous cell carcinoma, precancerous lesions, clonal expansion, tumor suppressor, proto-oncogenes, p16INK4a, p53, cyclin D1, p14ARF, FHIT, RASSF1A, epidermal growth factor receptor, retinoblastoma protein, local recurrence, second primary tumours, molecular heterogeneity
MeSH terms
Carcinoma, Squamous Cell, Head and Neck Neoplasms, Humans, Risk, Genes, Tumor Suppressor, DNA Fingerprinting, Gene Deletion, Disease Progression, Papillomavirus Infections

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