Molecular biology of squamous cell carcinoma of the head and neck
Open accessAbstract
Squamous cell carcinoma of the head and neck (HNSCC) is a heterogeneous but largely preventable disease with complex molecular abnormalities. It arises from a premalignant progenitor followed by outgrowth of clonal populations associated with cumulative genetic alterations and phenotypic progression to invasive malignancy. These genetic alterations result in inactivation of multiple tumour suppressor genes and activation of proto-oncogenes, including p16 ink4A , p53, cyclin D1, p14 ARF , FHIT , RASSF1A , epidermal growth factor receptor (EGFR), and Rb. Intramucosal migration and clonal expansion of transformed cells with formation of abnormal genetic fields appear to be responsible for local recurrences and development of second primary tumours.
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HPV initiates cervical carcinoma and head and neck squamous carcinoma in part by inactivating RB through E7.
“human papillomavirus (HPV) is thought to initiate cervical carcinoma and squamous cell carcinoma of the head and neck in part by inactivating RB through expression of the E7 oncoprotein21,22”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [22]
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Cellular mechanisms of tumour suppression by the retinoblastoma gene
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- Authors
- Perez-Ordoñez, B., Beauchemin, M., & Jordan, R. C. K.
- Affiliations
- Hôpital du Saint-Sacrement (CA)
- University of California, San Francisco (US)
- ORCID
- Jordan, R C K
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 2006-04-27
- Volume
- 59
- Issue
- 5
- Pages
- 445-453
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- PMC
- PMC1860277
- OpenAlex
- W2010703150
- Cited by
- 314
- References
- 118
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 5 · 2020: 5 · 2019: 12 · 2018: 12 · 2017: 16 · 2016: 20 · 2015: 20 · 2014: 23 · 2013: 20 · 2012: 23
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Keywords
- head and neck squamous cell carcinoma, precancerous lesions, clonal expansion, tumor suppressor, proto-oncogenes, p16INK4a, p53, cyclin D1, p14ARF, FHIT, RASSF1A, epidermal growth factor receptor, retinoblastoma protein, local recurrence, second primary tumours, molecular heterogeneity
- MeSH terms
- Carcinoma, Squamous Cell, Head and Neck Neoplasms, Humans, Risk, Genes, Tumor Suppressor, DNA Fingerprinting, Gene Deletion, Disease Progression, Papillomavirus Infections
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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