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Relapse Following Treatment Withdrawal in Patients with Autoimmune Chronic Active Hepatitis
Open accessAbstract
A prospective study was performed to evaluate the outcome of treatment withdrawal in 30 patients with “autoimmune” chronic active hepatitis in remission for periods of 1.5 to 9 years on maintenance corticosteroid and azathioprine therapy. Reactivation of disease, with marked rises in serum aminotransferase level (mean 668 ± S.D. 458 IU per liter) and accompanied by severe symptoms, occurred in 25 (87%) patients within 52 weeks (median 9 weeks; range 5 to 52) and was associated with the histological features of piecemeal necrosis and lobular hepatitis in all 20 liver biopsies examined. Age, sex, duration of disease and remission, presence of cirrhosis, autoantibody status, or immunoglobulin levels did not differentiate patients who relapsed from those who remained in remission. The response to reinstitution of treatment with prednisolone was satisfactory in 25 patients and clinical and biochemical abnormalities resolved within 10 weeks (median 6; range 3 to 10), death occurred in one patient within 48 hr of readmission to hospital.
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Citations
Cited by
Diagnosis and management of autoimmune hepatitis
Manns, M. P., Czaja, A. J., Gorham, J. D., Krawitt, E. L., Mieli-Vergani, G., Vergani, D., & Vierling, J. M. (2010) · Hepatology · doi:10.1002/hep.23584 · Cited by 1,442
EASL Clinical Practice Guidelines: autoimmune hepatitis
(2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.06.030 · Cited by 1,245
Mack, C. L., Adams, D., Assis, D. N., Kerkar, N., Manns, M. P., Mayo, M. J., Vierling, J. M., Alsawas, M., Murad, M. H., & Czaja, A. J. (2020) · Hepatology · doi:10.1002/hep.31065 · Cited by 983
Case definition and phenotype standardization in drug-induced liver injury
Aithal, G. P., Watkins, P. B., Andrade, R. J., Larrey, D., Molokhia, M., Takikawa, H., Hunt, C. M., Wilke, R. A., Avigan, M., Kaplowitz, N., et al. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.58 · Cited by 944
Azathioprine for Long-Term Maintenance of Remission in Autoimmune Hepatitis
Johnson, P. J., McFarlane, I. G., & Williams, R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510123331502 · Cited by 382
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Metadata
- Authors
- Hegarty, J. E., Nouri Aria, K. T., Portmann, B., Eddleston, A. L. W. F., & Williams, R.
- Venue
- Hepatology
- Published
- 1983-09
- Volume
- 3
- Issue
- 5
- Pages
- 685-689
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2099572876
- Cited by
- 174
- References
- 0
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hegarty, J. E., Nouri Aria, K. T., Portmann, B., Eddleston, A. L. W. F., & Williams, R. (1983). Relapse Following Treatment Withdrawal in Patients with Autoimmune Chronic Active Hepatitis. Hepatology. https://doi.org/10.1002/hep.1840030510
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
