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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Case Definition and Phenotype Standardization in Drug-Induced Liver Injury

Aithal, G P, Watkins, P B, Andrade, R J, Larrey, D, Molokhia, M, Takikawa, H, Hunt, C M, Wilke, R A, Avigan, M, Kaplowitz, N, Bjornsson, E, Daly, A K·2011·Clinical Pharmacology & Therapeutics
DOI 10.1038/clpt.2011.58
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Abstract

Drug-induced liver injury (DILI) is the most frequent reason cited for the withdrawal of approved drugs from the market and accounts for up to 15% of the cases of acute liver failure. Investigators around the globe have begun to identify and study patients with DILI; several large registries and tissue banks are being established. In order to gain the maximum scientific benefit from these efforts, the definitions and terminology related to the clinical phenotypes of DILI must be harmonized. For this purpose, an international DILI Expert Working Group of clinicians and scientists reviewed current DILI terminology and diagnostic criteria so as to develop more uniform criteria that would define and characterize the spectrum of clinical syndromes that constitute DILI. Consensus was established with respect to the threshold criteria for definition of a case as being DILI, the pattern of liver injury, causality assessment, severity, and chronicity. Consensus was also reached on approaches to characterizing DILI in the setting of chronic liver diseases, including autoimmune hepatitis (AIH).

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Crossref · 10.1038/clpt.2011.58

Cites

2 of 2 references verified0 citation errors · 0 not checkable

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  • The biochemical pattern of DILI is based on increased activity of aminotransferases and ALP, and can be categorized as primarily hepatocellular (serum ALT, AST activity at least 5× ULN or R ratio above 5), cholestatic (ALP activity at least twice the ULN or R ratio less than 2), or mixed (R ratio between 2 and 5).

    “The biochemical pattern of DILI is based on increased activity of aminotransferases and ALP, and in general it can be categorized as primarily hepatocellular (serum ALT, AST activity at least 5× ULN or R ratio above 5), cholestatic (ALP activity at least twice the ULN or R ratio less than 2), or mixed (R ratio between 2 and 5).”

    From Drug-induced liver injury. Part I: Classification, diagnosis and treatment (2025) · cites this paper as [11]

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Metadata

Authors
Aithal, G. P., Watkins, P. B., Andrade, R. J., Larrey, D., Molokhia, M., Takikawa, H., Hunt, C. M., Wilke, R. A., Avigan, M., Kaplowitz, N., Bjornsson, E., & Daly, A. K.
Venue
Clinical Pharmacology & Therapeutics
Publisher
Wiley
Published
2011-05-04
Volume
89
Issue
6
Pages
806-815
ISSN
  • 0009-9236
  • 1532-6535
DOI
10.1038/clpt.2011.58
Cited by
944
References
2

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